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@article{2403377, author = {Benešová, Iva and Urminský, Adam Paulin and Halámková, Jana and Hernychová, Lenka}, article_location = {Praha}, article_number = {3}, doi = {http://dx.doi.org/10.48095/ccko2022174}, keywords = {glycommics; glycoproteomics; N-glycans; N-glycan profiling; glycopeptides; serum proteins;, mass spectrometry}, issn = {0862-495X}, journal = {Časopis Klinická onkologie}, title = {Changes of serum protein N-glycosylation in cancer}, url = {https://www.linkos.cz/files/klinicka-onkologie/505/6058.pdf}, volume = {35}, year = {2022} }
TY - JOUR ID - 2403377 AU - Benešová, Iva - Urminský, Adam Paulin - Halámková, Jana - Hernychová, Lenka PY - 2022 TI - Changes of serum protein N-glycosylation in cancer JF - Časopis Klinická onkologie VL - 35 IS - 3 SP - 174-180 EP - 174-180 PB - Česká lékařská společnost J. E. Purkyně SN - 0862495X KW - glycommics KW - glycoproteomics KW - N-glycans KW - N-glycan profiling KW - glycopeptides KW - serum proteins;, mass spectrometry UR - https://www.linkos.cz/files/klinicka-onkologie/505/6058.pdf N2 - Glycosylation is a posttranslantional modification responsible for many biological processes including protein-protein interactions, cell signaling or cell cycle regulation. Changes in glycosylation of serum proteins reflects the status od tissues and cells in the organism and therefore can be used as markers for diagnosis of cancer, its progression and determination of its subtypes. N-glycan profiling is often used for characterization of N- glycosylation changes. It is based on the measurements of N-glycans released from the serum proteins. Beside the N-glycan profiling, glycoproteomic approach is emerging as it preserves the information about glycan composition, original protein, and its glycosylation sites. Purpose: This review covers existing works describing the changes in serum protein N-glycosylation in various cancer types. Attention was paid to both the glycomic and glycoproteomic approaches. The last part of the review shortly presents the analytical methods used for these analyses. ER -
BENEŠOVÁ, Iva, Adam Paulin URMINSKÝ, Jana HALÁMKOVÁ a Lenka HERNYCHOVÁ. Changes of serum protein N-glycosylation in cancer. \textit{Časopis Klinická onkologie}. Praha: Česká lékařská společnost J. E. Purkyně, 2022, roč.~35, č.~3, s.~174-180. ISSN~0862-495X. Dostupné z: https://dx.doi.org/10.48095/ccko2022174.
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