Dibenzocyclooctadiene Lignans from Schisandra chinensis with
Anti-Inflammatory Effects

J 2024

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET et. al.

Základní údaje

Originální název

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

Autoři

RYBNIKÁŘ, Michal (203 Česká republika, domácí), Milan MALANÍK (203 Česká republika, domácí), Karel ŠMEJKAL (203 Česká republika, domácí), Emil ŠVAJDLENKA (203 Česká republika, domácí), Polina SHPET (203 Česká republika, domácí), Pavel BABICA (203 Česká republika), Stefano DALL´ACQUA (380 Itálie), Ondřej SMIŠTÍK (203 Česká republika, domácí), Ondřej JURČEK (203 Česká republika, domácí) a Jakub TREML (203 Česká republika, domácí)

Vydání

International Journal of Molecular Sciences, BASEL, MDPI, 2024, 1661-6596

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.600 v roce 2022

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ijms25063465

UT WoS

001193322800001

Klíčová slova anglicky

anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis

Štítky

ÚMF, ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 8. 2024 08:20, PharmDr. Milan Malaník, Ph.D.

Anotace

V originále

Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.

Návaznosti

GA23-04655S, projekt VaV

Název: Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

Investor: Grantová agentura ČR, Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

LM2023069, projekt VaV

Název: Výzkumná infrastruktura RECETOX

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET, Pavel BABICA, Stefano DALL´ACQUA, Ondřej SMIŠTÍK, Ondřej JURČEK a Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. International Journal of Molecular Sciences. BASEL: MDPI, 2024, roč. 25, č. 6, s. 1-16. ISSN 1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms25063465.

@article{2405904,
   author = {Rybnikář, Michal and Malaník, Milan and Šmejkal, Karel and Švajdlenka, Emil and Shpet, Polina and Babica, Pavel and Dall´Acqua, Stefano and Smištík, Ondřej and Jurček, Ondřej and Treml, Jakub},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/ijms25063465},
   keywords = {anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis},
   language = {eng},
   issn = {1661-6596},
   journal = {International Journal of Molecular Sciences},
   title = {Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects},
   url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2405904
AU  - Rybnikář, Michal - Malaník, Milan - Šmejkal, Karel - Švajdlenka, Emil - Shpet, Polina - Babica, Pavel - Dall´Acqua, Stefano - Smištík, Ondřej - Jurček, Ondřej - Treml, Jakub
PY  - 2024
TI  - Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
JF  - International Journal of Molecular Sciences
VL  - 25
IS  - 6
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 16616596
KW  - anti-inflammatory
KW  - antioxidant
KW  - dibenzocyclooctadiene
KW  - gap junction
KW  - lignan
KW  - Schisandra chinensis
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects
N2  - Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.
ER  -

RYBNIKÁŘ, Michal, Milan MALANÍK, Karel ŠMEJKAL, Emil ŠVAJDLENKA, Polina SHPET, Pavel BABICA, Stefano DALL´ACQUA, Ondřej SMIŠTÍK, Ondřej JURČEK a Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. \textit{International Journal of Molecular Sciences}. BASEL: MDPI, 2024, roč.~25, č.~6, s.~1-16. ISSN~1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms25063465.

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