| JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ a Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. PLANTS-BASEL. BASEL: MDPI, 2024, roč. 13, č. 9, s. Neuvedeno, 10 s. ISSN 2223-7747. Dostupné z: https://dx.doi.org/10.3390/plants13091181. |
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@article{2405907,
author = {Jankovská, Dagmar and Jurčová, Nikol and Kubínová, Renata and Václavík, Jiří and Švajdlenka, Emil and Mascellani, Anna and Marsik, Petr and Bouzková, Kateřina and Malaník, Milan},
article_location = {BASEL},
article_number = {9},
doi = {http://dx.doi.org/10.3390/plants13091181},
keywords = {AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine},
language = {eng},
issn = {2223-7747},
journal = {PLANTS-BASEL},
title = {Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives},
url = {https://pubmed.ncbi.nlm.nih.gov/38732396/},
volume = {13},
year = {2024}
}
TY - JOUR
ID - 2405907
AU - Jankovská, Dagmar - Jurčová, Nikol - Kubínová, Renata - Václavík, Jiří - Švajdlenka, Emil - Mascellani, Anna - Marsik, Petr - Bouzková, Kateřina - Malaník, Milan
PY - 2024
TI - Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives
JF - PLANTS-BASEL
VL - 13
IS - 9
SP - Neuvedeno
EP - Neuvedeno
PB - MDPI
SN - 22237747
KW - AChE
KW - Amorpha fruticosa
KW - BuChE
KW - molecular docking
KW - putrescine
KW - spermidine
UR - https://pubmed.ncbi.nlm.nih.gov/38732396/
N2 - Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
ER -
JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ a Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. \textit{PLANTS-BASEL}. BASEL: MDPI, 2024, roč.~13, č.~9, s.~Neuvedeno, 10 s. ISSN~2223-7747. Dostupné z: https://dx.doi.org/10.3390/plants13091181.
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