Modern trends in the formulation of microparticles for lung
delivery using porogens: methods, principles and examples.

J 2024

Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples.

PEŠTÁLOVÁ, Andrea a Jan GAJDZIOK

Základní údaje

Originální název

Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples.

Autoři

PEŠTÁLOVÁ, Andrea (203 Česká republika, domácí) a Jan GAJDZIOK (203 Česká republika, domácí)

Vydání

Pharmaceutical Development and Technology, England, Taylor & Francis, 2024, 1097-9867

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.400 v roce 2022

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1080/10837450.2024.2350530

Klíčová slova anglicky

Microparticles; inhalation; porogens; porosity; porous particles; spray drying

Štítky

rivok, ÚFT

Změněno: 30. 5. 2024 10:51, PharmDr. Andrea Peštálová

Anotace

V originále

Inhalation drug administration is increasingly used for local pharmacotherapy of lung disorders and as an alternative route for systemic drug delivery. Modern inhalation powder systems aim to target drug deposition in the required site of action. Large porous particles (LPP), characterized by an aerodynamic diameter over 5mum, density below 0.4g/cm3, and the ability to avoid protective lung mechanisms, come to the forefront of the research. They are mostly prepared by spray techniques such as spray drying or lyophilization using pore-forming substances (porogens). These substances could be gaseous, solid, or liquid, and their selection depends on their polarity, solubility, and mutual compatibility with the carrier material and the drug. According to the pores-forming mechanism, porogens can be divided into groups, such as osmogens, extractable porogens, and porogens developing gases during decomposition. This review characterizes modern trends in the formulation of solid microparticles for lung delivery; describes the mechanisms of action of the most often used porogens, discusses their applicability in various formulation methods, emphasizes spray techniques; and documents discussed topics by examples from experimental studies.

Návaznosti

MUNI/A/1232/2021, interní kód MU

Název: Design a syntéza nových fluoroforů pro detekci biomolekul

Investor: Masarykova univerzita, Design a syntéza nových fluoroforů pro detekci biomolekul

Citovat

PEŠTÁLOVÁ, Andrea a Jan GAJDZIOK. Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples. Pharmaceutical Development and Technology. England: Taylor & Francis, 2024, Neuvedeno, Neuvedeno, s. 1-13. ISSN 1097-9867. Dostupné z: https://dx.doi.org/10.1080/10837450.2024.2350530.

@article{2405920,
   author = {Peštálová, Andrea and Gajdziok, Jan},
   article_location = {England},
   article_number = {Neuvedeno},
   doi = {http://dx.doi.org/10.1080/10837450.2024.2350530},
   keywords = {Microparticles; inhalation; porogens; porosity; porous particles; spray drying},
   language = {eng},
   issn = {1097-9867},
   journal = {Pharmaceutical Development and Technology},
   title = {Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples.},
   url = {https://www.tandfonline.com/doi/full/10.1080/10837450.2024.2350530?scroll=top&needAccess=true},
   volume = {Neuvedeno},
   year = {2024}
}

TY  - JOUR
ID  - 2405920
AU  - Peštálová, Andrea - Gajdziok, Jan
PY  - 2024
TI  - Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples.
JF  - Pharmaceutical Development and Technology
VL  - Neuvedeno
IS  - Neuvedeno
SP  - 1-13
EP  - 1-13
PB  - Taylor & Francis
SN  - 10979867
KW  - Microparticles
KW  - inhalation
KW  - porogens
KW  - porosity
KW  - porous particles
KW  - spray drying
UR  - https://www.tandfonline.com/doi/full/10.1080/10837450.2024.2350530?scroll=top&needAccess=true
N2  - Inhalation drug administration is increasingly used for local pharmacotherapy of lung disorders and as an alternative route for systemic drug delivery. Modern inhalation powder systems aim to target drug deposition in the required site of action. Large porous particles (LPP), characterized by an aerodynamic diameter over 5mum, density below 0.4g/cm3, and the ability to avoid protective lung mechanisms, come to the forefront of the research. They are mostly prepared by spray techniques such as spray drying or lyophilization using pore-forming substances (porogens). These substances could be gaseous, solid, or liquid, and their selection depends on their polarity, solubility, and mutual compatibility with the carrier material and the drug. According to the pores-forming mechanism, porogens can be divided into groups, such as osmogens, extractable porogens, and porogens developing gases during decomposition. This review characterizes modern trends in the formulation of solid microparticles for lung delivery; describes the mechanisms of action of the most often used porogens, discusses their applicability in various formulation methods, emphasizes spray techniques; and documents discussed topics by examples from experimental studies.
ER  -

PEŠTÁLOVÁ, Andrea a Jan GAJDZIOK. Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples. \textit{Pharmaceutical Development and Technology}. England: Taylor \&{} Francis, 2024, Neuvedeno, Neuvedeno, s.~1-13. ISSN~1097-9867. Dostupné z: https://dx.doi.org/10.1080/10837450.2024.2350530.

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