Critical view on antimicrobial, antibiofilm and cytotoxic
activities of quinazolin-4(3H)-one derived schiff bases and
their Cu(II) complexes

J 2024

Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes

PINDJAKOVA, Dominika, Sarka MASCARETTI, Jana HRICOVINIOVA, Jan HOSEK, Jana GREGOROVÁ et. al.

Základní údaje

Originální název

Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes

Autoři

PINDJAKOVA, Dominika, Sarka MASCARETTI (203 Česká republika), Jana HRICOVINIOVA, Jan HOSEK (203 Česká republika), Jana GREGOROVÁ (203 Česká republika, domácí), Jiří KOS (203 Česká republika, domácí), Alois CIZEK (203 Česká republika), Zuzana HRICOVINIOVA a Josef JAMPILEK (203 Česká republika)

Vydání

Heliyon, OXFORD, ELSEVIER, 2024, 2405-8440

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.000 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.heliyon.2024.e29051

UT WoS

001227020400001

Klíčová slova anglicky

Quinazolinones; Schiff bases; Cu(II) complexes; Antibacterial activity; Antibiofilm effect; Cytotoxicity

Štítky

14110512, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 7. 2024 09:36, Mgr. Tereza Miškechová

Anotace

V originále

A series of nine 2,3-disubstituted-quinazolin-4(3 H )-one derived Schiff bases and their three Cu(II) complexes was prepared and tested for their antimicrobial activities against reference strains Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 and resistant clinical isolates of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). All the substances were tested in vitro against Mycobacterium tuberculosis H 37 Ra ATCC 25177, M. kansasii DSM 44162 and M. smegmatis ATCC 700084. While anti-enterococcal and antimycobacterial activities were insignificant, 3-[( E )-(2-hydroxy-5-nitrobenzylidene)amino]-2-(2- hydroxy-5-nitrophenyl)-2,3-dihydroquinazolin-4(1 H )-one ( SB3 ) and its Cu(II) complex ( SB3 -Cu ) demonstrated bacteriostatic antistaphylococcal activity. In addition, both compounds, as well as the other two prepared complexes, showed antibiofilm activity, which resulted in a reduction of biofilm formation and eradication of mature S. aureus biofilm by 80% even at concentrations lower than the values of their minimum inhibitory concentrations. In addition, the compounds were tested for their cytotoxic effect on the human monocytic leukemia cell line THP-1. The antileukemic efficiency was improved by the preparation of Cu(II) complexes from the corresponding non-chelated Schiff base ligands.

Návaznosti

ROZV/28/LF10/2020, interní kód MU

Název: Metabolické profilování nizkomolekulárních látek pomocí hmotnostní spektrometrie

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Metabolické profilování nizkomolekulárních látek pomocí hmotnostní spektrometrie, Interní rozvojové projekty

Citovat

PINDJAKOVA, Dominika, Sarka MASCARETTI, Jana HRICOVINIOVA, Jan HOSEK, Jana GREGOROVÁ, Jiří KOS, Alois CIZEK, Zuzana HRICOVINIOVA a Josef JAMPILEK. Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes. Heliyon. OXFORD: ELSEVIER, 2024, roč. 10, č. 7, s. 1-10. ISSN 2405-8440. Dostupné z: https://dx.doi.org/10.1016/j.heliyon.2024.e29051.

@article{2409560,
   author = {Pindjakova, Dominika and Mascaretti, Sarka and Hricoviniova, Jana and Hosek, Jan and Gregorová, Jana and Kos, Jiří and Cizek, Alois and Hricoviniova, Zuzana and Jampilek, Josef},
   article_location = {OXFORD},
   article_number = {7},
   doi = {http://dx.doi.org/10.1016/j.heliyon.2024.e29051},
   keywords = {Quinazolinones; Schiff bases; Cu(II) complexes; Antibacterial activity; Antibiofilm effect; Cytotoxicity},
   language = {eng},
   issn = {2405-8440},
   journal = {Heliyon},
   title = {Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes},
   url = {https://www.sciencedirect.com/science/article/pii/S2405844024050825?via%3Dihub},
   volume = {10},
   year = {2024}
}

TY  - JOUR
ID  - 2409560
AU  - Pindjakova, Dominika - Mascaretti, Sarka - Hricoviniova, Jana - Hosek, Jan - Gregorová, Jana - Kos, Jiří - Cizek, Alois - Hricoviniova, Zuzana - Jampilek, Josef
PY  - 2024
TI  - Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes
JF  - Heliyon
VL  - 10
IS  - 7
SP  - 1-10
EP  - 1-10
PB  - ELSEVIER
SN  - 24058440
KW  - Quinazolinones
KW  - Schiff bases
KW  - Cu(II) complexes
KW  - Antibacterial activity
KW  - Antibiofilm effect
KW  - Cytotoxicity
UR  - https://www.sciencedirect.com/science/article/pii/S2405844024050825?via%3Dihub
N2  - A series of nine 2,3-disubstituted-quinazolin-4(3 H )-one derived Schiff bases and their three Cu(II) complexes was prepared and tested for their antimicrobial activities against reference strains Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 and resistant clinical isolates of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). All the substances were tested in vitro against Mycobacterium tuberculosis H 37 Ra ATCC 25177, M. kansasii DSM 44162 and M. smegmatis ATCC 700084. While anti-enterococcal and antimycobacterial activities were insignificant, 3-[( E )-(2-hydroxy-5-nitrobenzylidene)amino]-2-(2- hydroxy-5-nitrophenyl)-2,3-dihydroquinazolin-4(1 H )-one ( SB3 ) and its Cu(II) complex ( SB3 -Cu ) demonstrated bacteriostatic antistaphylococcal activity. In addition, both compounds, as well as the other two prepared complexes, showed antibiofilm activity, which resulted in a reduction of biofilm formation and eradication of mature S. aureus biofilm by 80% even at concentrations lower than the values of their minimum inhibitory concentrations. In addition, the compounds were tested for their cytotoxic effect on the human monocytic leukemia cell line THP-1. The antileukemic efficiency was improved by the preparation of Cu(II) complexes from the corresponding non-chelated Schiff base ligands.
ER  -

PINDJAKOVA, Dominika, Sarka MASCARETTI, Jana HRICOVINIOVA, Jan HOSEK, Jana GREGOROVÁ, Jiří KOS, Alois CIZEK, Zuzana HRICOVINIOVA a Josef JAMPILEK. Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes. \textit{Heliyon}. OXFORD: ELSEVIER, 2024, roč.~10, č.~7, s.~1-10. ISSN~2405-8440. Dostupné z: https://dx.doi.org/10.1016/j.heliyon.2024.e29051.

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