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@article{2409580,
author = {Eekers, Danielle B P and Zegers, Catharina M L and Ahmed, Kamran A and Amelio, Dante and Gupta, Tejpal and Harrabi, Semi Ben and Kazda, Tomáš and Scartoni, Daniele and Seidel, Clemens and Shih, Helen A and Minniti, Giuseppe},
article_location = {OXFORD},
doi = {http://dx.doi.org/10.1093/nop/npae040},
keywords = {brain tumors; chordomas; gliomas; meningiomas; proton beam; radiotherapy; radiosurgery},
language = {eng},
issn = {2054-2577},
journal = {NEURO-ONCOLOGY PRACTICE},
title = {Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors},
url = {https://academic.oup.com/nop/advance-article/doi/10.1093/nop/npae040/7659617?login=true},
year = {2024}
}
TY - JOUR
ID - 2409580
AU - Eekers, Danielle B P - Zegers, Catharina M L - Ahmed, Kamran A - Amelio, Dante - Gupta, Tejpal - Harrabi, Semi Ben - Kazda, Tomáš - Scartoni, Daniele - Seidel, Clemens - Shih, Helen A - Minniti, Giuseppe
PY - 2024
TI - Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors
JF - NEURO-ONCOLOGY PRACTICE
PB - OXFORD UNIV PRESS
SN - 20542577
KW - brain tumors
KW - chordomas
KW - gliomas
KW - meningiomas
KW - proton beam
KW - radiotherapy
KW - radiosurgery
UR - https://academic.oup.com/nop/advance-article/doi/10.1093/nop/npae040/7659617?login=true
N2 - Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.
ER -
EEKERS, Danielle B P, Catharina M L ZEGERS, Kamran A AHMED, Dante AMELIO, Tejpal GUPTA, Semi Ben HARRABI, Tomáš KAZDA, Daniele SCARTONI, Clemens SEIDEL, Helen A SHIH a Giuseppe MINNITI. Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors. \textit{NEURO-ONCOLOGY PRACTICE}. OXFORD: OXFORD UNIV PRESS, 2024, 14 s. ISSN~2054-2577. Dostupné z: https://dx.doi.org/10.1093/nop/npae040.
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