Impact of physiological loads of arterial wall on nucleus
deformation in endothelial cells: A computational study

J 2022

Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study

JAKKA, Veera Venkata Satya Varaprasad a Jiri BURSA

Základní údaje

Originální název

Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study

Autoři

JAKKA, Veera Venkata Satya Varaprasad a Jiri BURSA

Vydání

Computers in Biology and Medicine, Oxford, Pergamon-Elsevier Science Press, 2022, 0010-4825

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10201 Computer sciences, information science, bioinformatics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.700

DOI

http://dx.doi.org/10.1016/j.compbiomed.2022.105266

UT WoS

000788097600006

Klíčová slova anglicky

Cell mechanics; Biaxial load; Finite element model; Bendo-tensegrity; Shear load

Štítky

CF CELLIM, ne MU

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 6. 2024 12:07, Mgr. Eva Dubská

Anotace

V originále

Introduction: Computational modeling can enhance the understanding of cell mechanics. To achieve this, finite element models of endothelial cells were proposed with shapes mimicking their natural state inside the endothelium within the cardiovascular system. Implementing the recently proposed bendo-tensegrity concept, these models consider flexural (buckling) as well as tensional/compressional behavior of microtubules and also incorporate the waviness of intermediate filaments.Materials and methods: Four different models were created (flat and domed hexagons, both regular and elongated in the direction of blood flow) and loaded by biaxial deformation, blood pressure, and shear load from blood flow - natural physiological conditions of the arterial endothelium - aiming to investigate the "in situ" mechanical response of the cell.Results: The impact of individual components of loads on the nucleus deformation (more specifically on the first principal strain) potentially influencing mechanotransduction was investigated and the role of the cytoskeleton and its constituents in the mechanical response of the endothelial cell was assessed. The results show (i) the impact of pulsating blood pressure on cyclic deformations of the nucleus, which increase substantially with decreasing axial pre-stretch of the cell, (ii) the importance of relatively low shear stresses in the cell response and nucleus deformation.Conclusion: Not only the pulsatile blood pressure but also the wall shear stress may induce significant deformation of the nucleus and thus trigger remodelation processes in endothelial cells.

Citovat

JAKKA, Veera Venkata Satya Varaprasad a Jiri BURSA. Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study. Computers in Biology and Medicine. Oxford: Pergamon-Elsevier Science Press, 2022, roč. 143, Apr, s. 1-11. ISSN 0010-4825. Dostupné z: https://dx.doi.org/10.1016/j.compbiomed.2022.105266.

@article{2409878,
   author = {Jakka, Veera Venkata Satya Varaprasad and Bursa, Jiri},
   article_location = {Oxford},
   article_number = {Apr},
   doi = {http://dx.doi.org/10.1016/j.compbiomed.2022.105266},
   keywords = {Cell mechanics; Biaxial load; Finite element model; Bendo-tensegrity; Shear load},
   language = {eng},
   issn = {0010-4825},
   journal = {Computers in Biology and Medicine},
   title = {Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study},
   url = {https://www.sciencedirect.com/science/article/pii/S0010482522000580?via%3Dihub},
   volume = {143},
   year = {2022}
}

TY  - JOUR
ID  - 2409878
AU  - Jakka, Veera Venkata Satya Varaprasad - Bursa, Jiri
PY  - 2022
TI  - Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study
JF  - Computers in Biology and Medicine
VL  - 143
IS  - Apr
SP  - 1-11
EP  - 1-11
PB  - Pergamon-Elsevier Science Press
SN  - 00104825
KW  - Cell mechanics
KW  - Biaxial load
KW  - Finite element model
KW  - Bendo-tensegrity
KW  - Shear load
UR  - https://www.sciencedirect.com/science/article/pii/S0010482522000580?via%3Dihub
N2  - Introduction: Computational modeling can enhance the understanding of cell mechanics. To achieve this, finite element models of endothelial cells were proposed with shapes mimicking their natural state inside the endothelium within the cardiovascular system. Implementing the recently proposed bendo-tensegrity concept, these models consider flexural (buckling) as well as tensional/compressional behavior of microtubules and also incorporate the waviness of intermediate filaments.Materials and methods: Four different models were created (flat and domed hexagons, both regular and elongated in the direction of blood flow) and loaded by biaxial deformation, blood pressure, and shear load from blood flow - natural physiological conditions of the arterial endothelium - aiming to investigate the "in situ" mechanical response of the cell.Results: The impact of individual components of loads on the nucleus deformation (more specifically on the first principal strain) potentially influencing mechanotransduction was investigated and the role of the cytoskeleton and its constituents in the mechanical response of the endothelial cell was assessed. The results show (i) the impact of pulsating blood pressure on cyclic deformations of the nucleus, which increase substantially with decreasing axial pre-stretch of the cell, (ii) the importance of relatively low shear stresses in the cell response and nucleus deformation.Conclusion: Not only the pulsatile blood pressure but also the wall shear stress may induce significant deformation of the nucleus and thus trigger remodelation processes in endothelial cells.
ER  -

JAKKA, Veera Venkata Satya Varaprasad a Jiri BURSA. Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study. \textit{Computers in Biology and Medicine}. Oxford: Pergamon-Elsevier Science Press, 2022, roč.~143, Apr, s.~1-11. ISSN~0010-4825. Dostupné z: https://dx.doi.org/10.1016/j.compbiomed.2022.105266.

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