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@article{2416017,
author = {Bugajová, Mária and Raudenská, Martina and Masařík, Michal and Kalfert, David and Betka, Jan and Balvan, Jan},
article_location = {HOBOKEN},
doi = {http://dx.doi.org/10.1002/ijc.35035},
keywords = {metastasis; resistance to therapy; RNA; small extracellular vesicles; tumour microenvironment},
language = {eng},
issn = {0020-7136},
journal = {International journal of cancer},
title = {RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment},
url = {https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035},
year = {2024}
}
TY - JOUR
ID - 2416017
AU - Bugajová, Mária - Raudenská, Martina - Masařík, Michal - Kalfert, David - Betka, Jan - Balvan, Jan
PY - 2024
TI - RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment
JF - International journal of cancer
PB - International Union Against Cancer
SN - 00207136
KW - metastasis
KW - resistance to therapy
KW - RNA
KW - small extracellular vesicles
KW - tumour microenvironment
UR - https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035
N2 - Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.
ER -
BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA a Jan BALVAN. RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment. \textit{International journal of cancer}. HOBOKEN: International Union Against Cancer, 2024, 15 s. ISSN~0020-7136. Dostupné z: https://dx.doi.org/10.1002/ijc.35035.
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