RNAs in tumour-derived extracellular vesicles and their
significance in the tumour microenvironment

J 2024

RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA et. al.

Základní údaje

Originální název

RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment

Autoři

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA a Jan BALVAN

Vydání

International journal of cancer, HOBOKEN, International Union Against Cancer, 2024, 0020-7136

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.400 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/ijc.35035

UT WoS

001240512100001

Klíčová slova anglicky

metastasis; resistance to therapy; RNA; small extracellular vesicles; tumour microenvironment

Štítky

14110515, 14110518

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 7. 2024 14:15, Mgr. Tereza Miškechová

Anotace

V originále

Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.

Návaznosti

GA21-06873S, projekt VaV

Název: Metabolická symbióza mezi nádorovými buňkami a fibroblasty asociovaných s nádorem u nádorů v oblasti hlavy a krku

Investor: Grantová agentura ČR, Metabolic symbiosis between cancer cells and cancer-associated fibroblasts in head and neck cancer

MUNI/A/1343/2022, interní kód MU

Název: Zátěže kardiovaskulárního systému od A po Z

Investor: Masarykova univerzita, Zátěže kardiovaskulárního systému od A po Z

MUNI/A/1370/2022, interní kód MU

Název: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masarykova univerzita, Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

NU20J-08-00018, projekt VaV

Název: Exosomální RNA produkovaná fibroblasty asociovanými s nádorem jako relevantní marker v prognóze nádorů hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Exosomální RNA produkovaná fibroblasty asociovanými s nádorem jako relevantní marker v prognóze nádorů hlavy a krku, Podprogram 2 - juniorský - výzkumníci do 35 let

Citovat

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA a Jan BALVAN. RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment. International journal of cancer. HOBOKEN: International Union Against Cancer, 2024, 15 s. ISSN 0020-7136. Dostupné z: https://dx.doi.org/10.1002/ijc.35035.

@article{2416017,
   author = {Bugajová, Mária and Raudenská, Martina and Masařík, Michal and Kalfert, David and Betka, Jan and Balvan, Jan},
   article_location = {HOBOKEN},
   doi = {http://dx.doi.org/10.1002/ijc.35035},
   keywords = {metastasis; resistance to therapy; RNA; small extracellular vesicles; tumour microenvironment},
   language = {eng},
   issn = {0020-7136},
   journal = {International journal of cancer},
   title = {RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035},
   year = {2024}
}

TY  - JOUR
ID  - 2416017
AU  - Bugajová, Mária - Raudenská, Martina - Masařík, Michal - Kalfert, David - Betka, Jan - Balvan, Jan
PY  - 2024
TI  - RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment
JF  - International journal of cancer
PB  - International Union Against Cancer
SN  - 00207136
KW  - metastasis
KW  - resistance to therapy
KW  - RNA
KW  - small extracellular vesicles
KW  - tumour microenvironment
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijc.35035
N2  - Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.
ER  -

BUGAJOVÁ, Mária, Martina RAUDENSKÁ, Michal MASAŘÍK, David KALFERT, Jan BETKA a Jan BALVAN. RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment. \textit{International journal of cancer}. HOBOKEN: International Union Against Cancer, 2024, 15 s. ISSN~0020-7136. Dostupné z: https://dx.doi.org/10.1002/ijc.35035.

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