2024
Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, Yuliya S NIKOLOVA et. al.Základní údaje
Originální název
Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
Autoři
MAREČKOVÁ, Klára (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Lenka ANDRÝSKOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Yuliya S NIKOLOVA
Vydání
Translational Psychiatry, London, Springer Nature, 2024, 2158-3188
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30215 Psychiatry
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 6.800 v roce 2022
Organizační jednotka
Lékařská fakulta
UT WoS
001234528500002
Klíčová slova anglicky
alcohol; prenatal exposure; reward processing; substance use
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 6. 8. 2024 11:10, Mgr. Tereza Miškechová
Anotace
V originále
Heavy maternal alcohol drinking during pregnancy has been associated with altered neurodevelopment in the child but the effects of low-dose alcohol drinking are less clear and any potential safe level of alcohol use during pregnancy is not known. We evaluated the effects of prenatal alcohol on reward-related behavior and substance use in young adulthood and the potential sex differences therein. Participants were members of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) prenatal birth cohort who participated in its neuroimaging follow-up in young adulthood. A total of 191 participants (28-30 years; 51% men) had complete data on prenatal exposure to alcohol, current substance use, and fMRI data from young adulthood. Maternal alcohol drinking was assessed during mid-pregnancy and pre-conception. Brain response to reward anticipation and reward feedback was measured using the Monetary Incentive Delay task and substance use in young adulthood was assessed using a self-report questionnaire. We showed that even a moderate exposure to alcohol in mid-pregnancy but not pre-conception was associated with robust effects on brain response to reward feedback (six frontal, one parietal, one temporal, and one occipital cluster) and with greater cannabis use in both men and women 30 years later. Moreover, mid-pregnancy but not pre-conception exposure to alcohol was associated with greater cannabis use in young adulthood and these effects were independent of maternal education and maternal depression during pregnancy. Further, the extent of cannabis use in the late 20 s was predicted by the brain response to reward feedback in three out of the nine prenatal alcohol-related clusters and these effects were independent of current alcohol use. Sex differences in the brain response to reward outcome emerged only during the no loss vs. loss contrast. Young adult men exposed to alcohol prenatally had significantly larger brain response to no loss vs. loss in the putamen and occipital region than women exposed to prenatal alcohol. Therefore, we conclude that even moderate exposure to alcohol prenatally has long-lasting effects on brain function during reward processing and risk of cannabis use in young adulthood.
Návaznosti
| EF17_043/0009632, projekt VaV |
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| GM24-12183M, projekt VaV |
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| LM2018121, projekt VaV |
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| LM2018129, projekt VaV |
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| LQ1601, projekt VaV |
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| NU20J-04-00022, projekt VaV |
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