| ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA a Ondrej SLANAR. Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters. Cancer Biomarkers. Amsterdam: IOS Press, 2024, roč. 40, č. 1, s. 61-78. ISSN 1574-0153. Dostupné z: https://dx.doi.org/10.3233/CBM-230259. |
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@article{2417617,
author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Kohoutova, Milada and Slanar, Ondrej},
article_location = {Amsterdam},
article_number = {1},
doi = {http://dx.doi.org/10.3233/CBM-230259},
keywords = {Breast cancer; GNG12-AS1; clinical outcomes; long non-coding RNAs; MAGI2-AS3; MEG3; NRSN2-AS1; PTENP1; UCA1},
language = {eng},
issn = {1574-0153},
journal = {Cancer Biomarkers},
title = {Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters},
url = {https://content.iospress.com/articles/cancer-biomarkers/cbm230259},
volume = {40},
year = {2024}
}
TY - JOUR
ID - 2417617
AU - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Kohoutova, Milada - Slanar, Ondrej
PY - 2024
TI - Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters
JF - Cancer Biomarkers
VL - 40
IS - 1
SP - 61-78
EP - 61-78
PB - IOS Press
SN - 15740153
KW - Breast cancer
KW - GNG12-AS1
KW - clinical outcomes
KW - long non-coding RNAs
KW - MAGI2-AS3
KW - MEG3
KW - NRSN2-AS1
KW - PTENP1
KW - UCA1
UR - https://content.iospress.com/articles/cancer-biomarkers/cbm230259
N2 - BACKGROUND: Breast cancer is the most commonly occurring cancer worldwide and is the main cause of death from cancer in women. Novel biomarkers are highly warranted for this disease. OBJECTIVE: Evaluation of novel long non-coding RNAs biomarkers for breast cancer. METHODS: The study comprised the analysis of the expression of 71 candidate lncRNAs via screening, six of which (four underexpressed, two overexpressed) were validated and analyzed by qPCR in tumor tissues associated with NST breast carcinomas, compared with the benign samples and with respect to their clinicopathological characteristics. RESULTS: The results indicated the tumor suppressor roles of PTENP1, GNG12-AS1, MEG3 and MAGI2-AS3. Low levels of both PTENP1 and GNG12-AS1 were associated with worsened progression-free and overall survival rates. The reduced expression of GNG12-AS1 was linked to the advanced stage. A higher grade was associated with the lower expression of PTENP1, GNG12-AS1 and MAGI2-AS3. Reduced levels of both MEG3 and PTENP1 were linked to Ki-67 positivity. The NRSN2-AS1 and UCA1 lncRNAs were overexpressed; higher levels of UCA1 were associated with multifocality. CONCLUSIONS: The results suggest that the investigated lncRNAs may play important roles in breast cancer and comprise a potential factor that should be further evaluated in clinical studies.
ER -
ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Milada KOHOUTOVA a Ondrej SLANAR. Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters. \textit{Cancer Biomarkers}. Amsterdam: IOS Press, 2024, roč.~40, č.~1, s.~61-78. ISSN~1574-0153. Dostupné z: https://dx.doi.org/10.3233/CBM-230259.
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