SKERENOVA, Maria, Michal CIBULKA, Zuzana DANKOVA, Veronika HOLUBEKOVA, Zuzana KOLKOVA, Vincent LUCANSKY, Dana DVORSKA, Andrea KAPINOVA, Michaela KRIVOSOVA, Martin PETRAS, Eva BARANOVICOVA, Ivana BARANOVA, Elena NOVAKOVA, Peter LIPTAK, Peter BANOVCIN, Anna BOBCAKOVA, Robert ROSOLANKA, Maria JANICKOVA, Andrea STANCLOVA, Ludovit GASPAR, Martin CAPRNDA, Robert PROSECKÝ, Monika LABUDOVA, Zufar GABBASOV, Luis RODRIGO, Peter KRUŽLIAK, Zora LASABOVA, Tatiana MATAKOVA a Erika HALASOVA. Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort. Advances in Medical Sciences. WROCLAW: ELSEVIER URBAN & PARTNER SP Z O O, 2024, roč. 69, č. 1, s. 198-207. ISSN 1896-1126. Dostupné z: https://dx.doi.org/10.1016/j.advms.2024.03.007.
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Základní údaje
Originální název Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort
Autoři SKERENOVA, Maria, Michal CIBULKA, Zuzana DANKOVA, Veronika HOLUBEKOVA, Zuzana KOLKOVA, Vincent LUCANSKY, Dana DVORSKA, Andrea KAPINOVA, Michaela KRIVOSOVA, Martin PETRAS, Eva BARANOVICOVA, Ivana BARANOVA, Elena NOVAKOVA, Peter LIPTAK, Peter BANOVCIN, Anna BOBCAKOVA, Robert ROSOLANKA, Maria JANICKOVA, Andrea STANCLOVA, Ludovit GASPAR, Martin CAPRNDA, Robert PROSECKÝ (203 Česká republika, domácí), Monika LABUDOVA, Zufar GABBASOV, Luis RODRIGO, Peter KRUŽLIAK (703 Slovensko), Zora LASABOVA, Tatiana MATAKOVA a Erika HALASOVA.
Vydání Advances in Medical Sciences, WROCLAW, ELSEVIER URBAN & PARTNER SP Z O O, 2024, 1896-1126.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30230 Other clinical medicine subjects
Stát vydavatele Polsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 2.700 v roce 2022
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.advms.2024.03.007
UT WoS 001238411800001
Klíčová slova anglicky Haplotypes; Host genetic risk factors; Immunoregulatory pathways; Severe acute respiratory syndrome coronavirus 2; Single nucleotide variants
Štítky 14110116, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 9. 7. 2024 08:42.
Anotace
We present the results of an association study involving hospitalized coronavirus disease 2019 (COVID-19) patients with a clinical background during the 3rd pandemic wave of COVID-19 in Slovakia. Seventeen single nucleotide variants (SNVs) in the eleven most relevant genes, according to the COVID-19 Host Genetics Initiative, were investigated. Our study confirms the validity of the influence of LZTFL1 and 2 '-5 '-oligoadenylate synthetase (OAS)1/OAS3 genetic variants on the severity of COVID-19. For two LZTFL1 SNVs in complete linkage disequilibrium, rs17713054 and rs73064425, the odds ratios of baseline allelic associations and logistic regressions (LR) adjusted for age and sex ranged in the four tested designs from 2.04 to 2.41 and from 2.05 to 3.98, respectively. The OAS1/OAS3 haplotype 'gttg' carrying a functional allele G of splice-acceptor variant rs10774671 manifested its protective function in the Delta pandemic wave. Significant baseline allelic associations of two DPP9 variants in all tested designs and two IFNAR2 variants in the Omicron pandemic wave were not confirmed by adjusted LR. Nevertheless, adjusted LR showed significant associations of NOTCH4 rs3131294 and TYK2 rs2304256 variants with severity of COVID-19. Hospitalized patients' reported comorbidities were not correlated with genetic variants, except for obesity, smoking (IFNAR2), and hypertension (NOTCH4). The results of our study suggest that host genetic variations have an impact on the severity and duration of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Considering the differences in allelic associations between pandemic waves, they support the hypothesis that every new SARS-CoV-2 variant may modify the host immune response by reconfiguring involved pathways.
VytisknoutZobrazeno: 18. 7. 2024 01:42