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@article{2417959,
author = {Leskanicova, A. and Babincak, M. and Mochnacky, F. and Pipova Kokosova, N. and Kukelova, D. and Urbanská, Nicol and Kolesarova, M. and Macekova, D. and Kostolny, J. and Kiskova, T.},
article_location = {Krakow},
article_number = {4},
doi = {http://dx.doi.org/10.26402/jpp.2021.4.14},
keywords = {depression; metabolomics; stress; cortisol; adrenocorticotropin hormone; acylcarnitines; phosphatidylcholines; sexdependent; pathogenesis; gender},
language = {eng},
issn = {0867-5910},
journal = {Journal of Physiology and Pharmacology},
title = {SEX-DEPENDENT DIFFERENCES IN STRESS- INDUCED DEPRESSION IN WISTAR RATS ARE ACCOMPANIED PREDOMINANTLY BY CHANGES IN PHOSPHATIDYLCHOLINES AND SPHINGOMYELINS},
url = {https://jpp.krakow.pl/journal/archive/08_21/pdf/10.26402/jpp.2021.4.14.pdf},
volume = {72},
year = {2021}
}
TY - JOUR
ID - 2417959
AU - Leskanicova, A. - Babincak, M. - Mochnacky, F. - Pipova Kokosova, N. - Kukelova, D. - Urbanská, Nicol - Kolesarova, M. - Macekova, D. - Kostolny, J. - Kiskova, T.
PY - 2021
TI - SEX-DEPENDENT DIFFERENCES IN STRESS- INDUCED DEPRESSION IN WISTAR RATS ARE ACCOMPANIED PREDOMINANTLY BY CHANGES IN PHOSPHATIDYLCHOLINES AND SPHINGOMYELINS
JF - Journal of Physiology and Pharmacology
VL - 72
IS - 4
SP - 623-635
EP - 623-635
PB - Polish Physiological Society
SN - 08675910
KW - depression
KW - metabolomics
KW - stress
KW - cortisol
KW - adrenocorticotropin hormone
KW - acylcarnitines
KW - phosphatidylcholines
KW - sexdependent
KW - pathogenesis
KW - gender
UR - https://jpp.krakow.pl/journal/archive/08_21/pdf/10.26402/jpp.2021.4.14.pdf
N2 - With a high annual and lifetime prevalence, depression is becoming the leading contributor to the global disease burden. During the COVID-19 crisis, the depression and mood disorders accelerated significantly. Despite the growing evidence, the precise underlying mechanisms of depression disorders (DD) remain unknown. When studying DD in humans, there are many uncontrollable factors such as medication history, age of the patient or living conditions. In this regard, animal models provide an essential step for examining neural circuitry or molecular and cellular pathways in a controlled environment. As far as we know, women have a consistently higher prevalence of DD than men. Thus, the aim of our study was to evaluate sex-related changes in blood metabolites in a model of stress-induced depression in Wistar rats. Pregnant females were stressed using restriction of mobility in the final week of the pregnancy three times a day for 45 minutes each, three following days. After the birth, the progeny aged 60 days was stressed repeatedly. The perturbation in overall energy metabolism as well as in lipid metabolism was found. While in males, phosphatidylcholines (the most phosphatidylcholine with acyl-alkyl residue sum C40:4 - PC ae C40:4), sphingomyelins, and acylcarnitines were changed, in females, lipid metabolism perturbation was seen with the most critical alteration in hydroxysphingomyelin with acyl residue sum C16:1 (SM OH C16:1). Our results confirm that the animal model may be used further in the research of depression. Our results may provide an essential insight into the sex-dependent pathogenesis of depression and contribute to the search for effective treatment and prevention of depression with respect to sex.
ER -
LESKANICOVA, A., M. BABINCAK, F. MOCHNACKY, N. PIPOVA KOKOSOVA, D. KUKELOVA, Nicol URBANSKÁ, M. KOLESAROVA, D. MACEKOVA, J. KOSTOLNY a T. KISKOVA. SEX-DEPENDENT DIFFERENCES IN STRESS- INDUCED DEPRESSION IN WISTAR RATS ARE ACCOMPANIED PREDOMINANTLY BY CHANGES IN PHOSPHATIDYLCHOLINES AND SPHINGOMYELINS. \textit{Journal of Physiology and Pharmacology}. Krakow: Polish Physiological Society, 2021, roč.~72, č.~4, s.~623-635. ISSN~0867-5910. Dostupné z: https://dx.doi.org/10.26402/jpp.2021.4.14.
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