Prenatal exposure to air pollution and maternal depression:
Combined effects on brain aging and mental health in young
adulthood

J 2024

Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood

JÁNI, Martin, Ondřej MIKEŠ, Radek MAREČEK, Milan BRÁZDIL, Klára MAREČKOVÁ et. al.

Základní údaje

Originální název

Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood

Autoři

JÁNI, Martin (703 Slovensko, domácí), Ondřej MIKEŠ (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Klára MAREČKOVÁ (203 Česká republika, domácí)

Vydání

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2024, 0278-5846

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.600 v roce 2022

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.pnpbp.2024.111062

UT WoS

001258873600001

Klíčová slova anglicky

Air pollution; Maternal antenatal depression; Brain aging; Longitudinal; Prenatal birth cohort

Štítky

14110222, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 9. 2024 12:19, Mgr. Eva Dubská

Anotace

V originále

Introduction: Both maternal depression problems during pregnancy and prenatal exposure to air pollution have been associated with changes in the brain as well as worse mood and anxiety in the offspring in adulthood. However, it is not clear whether these effects are independent or whether and how they might interact and impact the brain age and mental health of the young adult offspring. Methods: A total of 202 mother-child dyads from a prenatal birth cohort were assessed for maternal depression during pregnancy through self-report questionnaires administered in the early 90s, exposure to air pollutants (Sulfur dioxide [SO2], nitrogen oxides [NOx], and suspended particle matter [SPM]) during each trimester based on maternal address and air quality data, mental health of the young adult offspring (28-30 years of age; 52% men, all of European ancestry) using self-report questionnaires for depression (Beck Depression Inventory), mood dysregulation (Profile of Mood States), anxiety (State-Trait Anxiety Inventory), and psychotic symptoms (Schizotypal Personality Questionnaire), and brain age, estimated from structural magnetic resonance imaging (MRI) and previously published neuroanatomical age prediction model using cortical thickness maps. The brain age gap estimate (BrainAGE) was computed by subtracting structural brain age from chronological age. Trajectories of exposure to air pollution during pregnancy were assessed using Growth Mixture Modeling. The interactions of prenatal depression and prenatal exposure to air pollutants on adult mental health and BrainAGE were assessed using hierarchical linear regression. Results: We revealed two distinct trajectories of exposure to air pollution during pregnancy: "early exposure," characterized by high exposure during the first trimester, followed by a steady decrease, and "late exposure," characterized by low exposure during the first trimester, followed by a steady increase in the exposure during the subsequent trimesters. Maternal depression during the first half of pregnancy interacted with NOX exposure trajectory, predicting mood dysregulation and schizotypal symptoms in young adults. In addition, maternal depression during the second half of pregnancy interacted with both NOx and SO2 exposure trajectories, respectively, and predicted BrainAGE in young adults. In those with early exposure to NOx, maternal depression during pregnancy was associated with worse mental health and accelerated brain aging in young adulthood. In contrast, in those with early exposure to SO2, maternal depression during pregnancy was associated with slower brain aging in young adulthood. Conclusions: Our findings provide the first evidence of the combined effects of prenatal exposure to air pollution and maternal depression on mental health outcomes and brain age in young adult offspring. Moreover, they point out the importance of the timing and trajectory of the exposure during prenatal development.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU20J-04-00022, projekt VaV

Název: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministerstvo zdravotnictví ČR, Zdravé stárnutí mozku: Celoživotní perspektiva, Podprogram 2 - juniorský - výzkumníci do 35 let

Citovat

JÁNI, Martin, Ondřej MIKEŠ, Radek MAREČEK, Milan BRÁZDIL a Klára MAREČKOVÁ. Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2024, roč. 134, August 2024, s. 1-8. ISSN 0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2024.111062.

@article{2418605,
   author = {Jáni, Martin and Mikeš, Ondřej and Mareček, Radek and Brázdil, Milan and Marečková, Klára},
   article_location = {OXFORD},
   article_number = {August 2024},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2024.111062},
   keywords = {Air pollution; Maternal antenatal depression; Brain aging; Longitudinal; Prenatal birth cohort},
   language = {eng},
   issn = {0278-5846},
   journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY},
   title = {Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood},
   url = {https://www.sciencedirect.com/science/article/pii/S0278584624001301?via%3Dihub},
   volume = {134},
   year = {2024}
}

TY  - JOUR
ID  - 2418605
AU  - Jáni, Martin - Mikeš, Ondřej - Mareček, Radek - Brázdil, Milan - Marečková, Klára
PY  - 2024
TI  - Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood
JF  - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY &BIOLOGICAL PSYCHIATRY
VL  - 134
IS  - August 2024
SP  - 1-8
EP  - 1-8
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - Air pollution
KW  - Maternal antenatal depression
KW  - Brain aging
KW  - Longitudinal
KW  - Prenatal birth cohort
UR  - https://www.sciencedirect.com/science/article/pii/S0278584624001301?via%3Dihub
N2  - Introduction: Both maternal depression problems during pregnancy and prenatal exposure to air pollution have been associated with changes in the brain as well as worse mood and anxiety in the offspring in adulthood. However, it is not clear whether these effects are independent or whether and how they might interact and impact the brain age and mental health of the young adult offspring. Methods: A total of 202 mother-child dyads from a prenatal birth cohort were assessed for maternal depression during pregnancy through self-report questionnaires administered in the early 90s, exposure to air pollutants (Sulfur dioxide [SO2], nitrogen oxides [NOx], and suspended particle matter [SPM]) during each trimester based on maternal address and air quality data, mental health of the young adult offspring (28-30 years of age; 52% men, all of European ancestry) using self-report questionnaires for depression (Beck Depression Inventory), mood dysregulation (Profile of Mood States), anxiety (State-Trait Anxiety Inventory), and psychotic symptoms (Schizotypal Personality Questionnaire), and brain age, estimated from structural magnetic resonance imaging (MRI) and previously published neuroanatomical age prediction model using cortical thickness maps. The brain age gap estimate (BrainAGE) was computed by subtracting structural brain age from chronological age. Trajectories of exposure to air pollution during pregnancy were assessed using Growth Mixture Modeling. The interactions of prenatal depression and prenatal exposure to air pollutants on adult mental health and BrainAGE were assessed using hierarchical linear regression. Results: We revealed two distinct trajectories of exposure to air pollution during pregnancy: "early exposure," characterized by high exposure during the first trimester, followed by a steady decrease, and "late exposure," characterized by low exposure during the first trimester, followed by a steady increase in the exposure during the subsequent trimesters. Maternal depression during the first half of pregnancy interacted with NOX exposure trajectory, predicting mood dysregulation and schizotypal symptoms in young adults. In addition, maternal depression during the second half of pregnancy interacted with both NOx and SO2 exposure trajectories, respectively, and predicted BrainAGE in young adults. In those with early exposure to NOx, maternal depression during pregnancy was associated with worse mental health and accelerated brain aging in young adulthood. In contrast, in those with early exposure to SO2, maternal depression during pregnancy was associated with slower brain aging in young adulthood. Conclusions: Our findings provide the first evidence of the combined effects of prenatal exposure to air pollution and maternal depression on mental health outcomes and brain age in young adult offspring. Moreover, they point out the importance of the timing and trajectory of the exposure during prenatal development.
ER  -

JÁNI, Martin, Ondřej MIKEŠ, Radek MAREČEK, Milan BRÁZDIL a Klára MAREČKOVÁ. Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{}BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2024, roč.~134, August 2024, s.~1-8. ISSN~0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2024.111062.

Podrobný výpis o publikaci