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@article{2420798,
author = {Aćimović, Ivana and Gabrielová, Viktorie and Martínková, Stanislava and Eid, Michal and Vlažný, Jakub and Moravčík, Petr and Hlavsa, Jan and Moráň, Lukáš and Cakmakci, Riza Can and Staňo, Peter and Procházka, Vladimír and Kala, Zdeněk and Trnka, Jan and Vaňhara, Petr},
article_location = {PHILADELPHIA},
doi = {http://dx.doi.org/10.1097/MPA.0000000000002393},
language = {eng},
issn = {0885-3177},
journal = {PANCREAS},
title = {Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology},
url = {https://journals.lww.com/pancreasjournal/abstract/9900/ex_vivo_3d_cellular_models_of_pancreatic_ductal.188.aspx},
year = {2024}
}
TY - JOUR
ID - 2420798
AU - Aćimović, Ivana - Gabrielová, Viktorie - Martínková, Stanislava - Eid, Michal - Vlažný, Jakub - Moravčík, Petr - Hlavsa, Jan - Moráň, Lukáš - Cakmakci, Riza Can - Staňo, Peter - Procházka, Vladimír - Kala, Zdeněk - Trnka, Jan - Vaňhara, Petr
PY - 2024
TI - Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology
JF - PANCREAS
PB - LIPPINCOTT WILLIAMS & WILKINS
SN - 08853177
UR - https://journals.lww.com/pancreasjournal/abstract/9900/ex_vivo_3d_cellular_models_of_pancreatic_ductal.188.aspx
N2 - Pancreas is a vital gland of gastro-intestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a five-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, the identification of novel molecular targets, and the development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing three-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.
ER -
A$\backslash$'CIMOVI$\backslash$'C, Ivana, Viktorie GABRIELOVÁ, Stanislava MARTÍNKOVÁ, Michal EID, Jakub VLAŽNÝ, Petr MORAVČÍK, Jan HLAVSA, Lukáš MORÁŇ, Riza Can CAKMAKCI, Peter STAŇO, Vladimír PROCHÁZKA, Zdeněk KALA, Jan TRNKA a Petr VAŇHARA. Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology. \textit{PANCREAS}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2024. ISSN~0885-3177. Dostupné z: https://dx.doi.org/10.1097/MPA.0000000000002393.
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