Fungal infection frequency in newly diagnosed acute myeloid
leukaemia patients treated with venetoclax plus azacitidine
with or without antifungal prophylaxis

J 2024

Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis

WEINBERGEROVÁ, Barbora; Jiří MAYER; Tomas KABUT; Wolfgang R SPERR; Jana STEVKOVA et al.

Základní údaje

Originální název

Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis

Autoři

Vydání

British journal of haematology, Hoboken, Wiley-Blackwell, 2024, 0007-1048

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.800

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00136679

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

acute myeloid leukaemia; antifungal prophylaxis; fungal infection; venetoclax and azacitidine

Štítky

14110212, 14119710, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 2. 2025 10:00, Mgr. Tereza Miškechová

Anotace

V originále

Our observational study analysed fungal infection frequency within cohorts with versus without antifungal prophylaxis (AFP) among newly diagnosed first-line venetoclax and azacitidine (VEN + AZA)-treated acute myeloid leukaemias in Czech, Austrian and Slovak haematology centres. Among 186 patients, 85 (46%) received antifungal prophylaxis, while 101 (54%) received no prophylaxis. Fungal infections occurred in 1/85 patients with prophylaxis (1%) and 5/101 patients without prophylaxis (5%) (p = 0.222). No significant difference was recorded between cohorts with and without AFP in terms of death rate (p = 0.296) and overall survival (p = 0.844). In conclusion, most infections were not severe, developing during the first treatment-cycle and did not affect patients' overall outcome.

Návaznosti

LX22NPO5102, projekt VaV

Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES

Přiložené soubory

Fungal_infection_frequency_in_newly_diagnosed_acute_myeloidleukaemia_patients_treated_with_venetoclax_plus_azacitidine_with_orwithout_antifungal_prophylaxis.pdf

Citovat

WEINBERGEROVÁ, Barbora; Jiří MAYER; Tomas KABUT; Wolfgang R SPERR; Jana STEVKOVA; Anna JONASOVA; Martin CERNAN; Susanne HERNDLHOFER; Iveta ORAVCOVA; Jiri SRAMEK; Jan NOVAK; Radka ŠTĚPÁNOVÁ; Tomas SZOTKOWSKI; Lubos DRGONA; Pavel ZAK a Peter VALENT. Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis. British journal of haematology. Hoboken: Wiley-Blackwell, 2024, roč. 205, č. 5, s. 1746-1750. ISSN 0007-1048. Dostupné z: https://doi.org/10.1111/bjh.19670.

@article{2421644,
   author = {Weinbergerová, Barbora and Mayer, Jiří and Kabut, Tomas and Sperr, Wolfgang R and Stevkova, Jana and Jonasova, Anna and Cernan, Martin and Herndlhofer, Susanne and Oravcova, Iveta and Sramek, Jiri and Novak, Jan and Štěpánová, Radka and Szotkowski, Tomas and Drgona, Lubos and Zak, Pavel and Valent, Peter},
   article_location = {Hoboken},
   article_number = {5},
   doi = {https://doi.org/10.1111/bjh.19670},
   keywords = {acute myeloid leukaemia; antifungal prophylaxis; fungal infection; venetoclax and azacitidine},
   language = {eng},
   issn = {0007-1048},
   journal = {British journal of haematology},
   title = {Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/bjh.19670},
   volume = {205},
   year = {2024}
}

TY  - JOUR
ID  - 2421644
AU  - Weinbergerová, Barbora - Mayer, Jiří - Kabut, Tomas - Sperr, Wolfgang R - Stevkova, Jana - Jonasova, Anna - Cernan, Martin - Herndlhofer, Susanne - Oravcova, Iveta - Sramek, Jiri - Novak, Jan - Štěpánová, Radka - Szotkowski, Tomas - Drgona, Lubos - Zak, Pavel - Valent, Peter
PY  - 2024
TI  - Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis
JF  - British journal of haematology
VL  - 205
IS  - 5
SP  - 1746-1750
EP  - 1746-1750
PB  - Wiley-Blackwell
SN  - 00071048
KW  - acute myeloid leukaemia
KW  - antifungal prophylaxis
KW  - fungal infection
KW  - venetoclax and azacitidine
UR  - https://onlinelibrary.wiley.com/doi/10.1111/bjh.19670
N2  - Our observational study analysed fungal infection frequency within cohorts with versus without antifungal prophylaxis (AFP) among newly diagnosed first-line venetoclax and azacitidine (VEN + AZA)-treated acute myeloid leukaemias in Czech, Austrian and Slovak haematology centres. Among 186 patients, 85 (46%) received antifungal prophylaxis, while 101 (54%) received no prophylaxis. Fungal infections occurred in 1/85 patients with prophylaxis (1%) and 5/101 patients without prophylaxis (5%) (p = 0.222). No significant difference was recorded between cohorts with and without AFP in terms of death rate (p = 0.296) and overall survival (p = 0.844). In conclusion, most infections were not severe, developing during the first treatment-cycle and did not affect patients' overall outcome.
ER  -

WEINBERGEROVÁ, Barbora; Jiří MAYER; Tomas KABUT; Wolfgang R SPERR; Jana STEVKOVA; Anna JONASOVA; Martin CERNAN; Susanne HERNDLHOFER; Iveta ORAVCOVA; Jiri SRAMEK; Jan NOVAK; Radka ŠTĚPÁNOVÁ; Tomas SZOTKOWSKI; Lubos DRGONA; Pavel ZAK a Peter VALENT. Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis. \textit{British journal of haematology}. Hoboken: Wiley-Blackwell, 2024, roč.~205, č.~5, s.~1746-1750. ISSN~0007-1048. Dostupné z: https://doi.org/10.1111/bjh.19670.

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