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@article{2421647,
author = {Siska Viragova, Eliska and Novotna, Lenka and Chlup, Zdenek and Stastny, Premysl and Sarfy, Pavlina and Cihlar, Jaroslav and Kučírek, Martin and Benák, Leoš and Streit, Libor and Kocanda, Jan and Sklenský, Jan and Filipovič, Milan and Repko, Martin and Hampl, Aleš and Koutná, Irena and Castkova, Klara},
article_location = {London},
doi = {http://dx.doi.org/10.1016/j.ceramint.2024.07.433},
keywords = {Calcium phosphates; Silica; In-situ foaming; Mechanical strength; In vitro response},
language = {eng},
issn = {0272-8842},
journal = {Ceramics International},
title = {Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method},
url = {https://www.sciencedirect.com/science/article/pii/S0272884224033790},
year = {2024}
}
TY - JOUR
ID - 2421647
AU - Siska Viragova, Eliska - Novotna, Lenka - Chlup, Zdenek - Stastny, Premysl - Sarfy, Pavlina - Cihlar, Jaroslav - Kučírek, Martin - Benák, Leoš - Streit, Libor - Kocanda, Jan - Sklenský, Jan - Filipovič, Milan - Repko, Martin - Hampl, Aleš - Koutná, Irena - Castkova, Klara
PY - 2024
TI - Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method
JF - Ceramics International
PB - Elsevier
SN - 02728842
KW - Calcium phosphates
KW - Silica
KW - In-situ foaming
KW - Mechanical strength
KW - In vitro response
UR - https://www.sciencedirect.com/science/article/pii/S0272884224033790
N2 - The effect of silica (SiO2) addition (0 wt%-20 wt%) on the microstructural and mechanical properties, as well as the in vitro response of calcium phosphate scaffolds for potential application in bone tissue engineering (BTE) was investigated in this research. Scaffolds characterized by high porosity (77%–88 %) and interconnected spherical pores with a broad range of pore sizes (5–600 μm) were fabricated using in-situ foaming method. Incorporated silica affected the phase transformation of hydroxyapatite (HA) to β-tricalcium phosphate (β-TCP) and led to the development of new crystalline silica-rich phases like silicocarnotite and wollastonite. The reinforcement of silica became apparent during the tests of mechanical properties. Scaffolds with 5 wt% of SiO2 exhibited compressive strength (1.13 MPa) higher than pure HA scaffolds (0.93 MPa). Bone bonding potential of the materials was tested in simulated body fluid (SBF), demonstrating this potential in silica-doped samples. Additionally, degradation experiments showed gradual material degradation, making it suitable for BTE applications. Furthermore, cell culture studies using human mesenchymal stromal cells (MSC) confirmed the scaffold's non-toxicity and provided insights into how the silica content influences cell viability, morphology, and osteogenic potential. The findings of this study offer valuable insights into the design and development of advanced scaffolds with tailored properties for effective BTE applications.
ER -
SISKA VIRAGOVA, Eliska, Lenka NOVOTNA, Zdenek CHLUP, Premysl STASTNY, Pavlina SARFY, Jaroslav CIHLAR, Martin KUČÍREK, Leoš BENÁK, Libor STREIT, Jan KOCANDA, Jan SKLENSKÝ, Milan FILIPOVIČ, Martin REPKO, Aleš HAMPL, Irena KOUTNÁ a Klara CASTKOVA. Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method. \textit{Ceramics International}. London: Elsevier, 2024. ISSN~0272-8842. Dostupné z: https://dx.doi.org/10.1016/j.ceramint.2024.07.433.
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