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@article{2421960,
author = {López Cabeza, María del Rocío and Eghbalinejad, Mahleh and Kah, Melanie and Grillo, Renato and Hochmanová, Zuzana and Kotouček, Jan and Hofman, Jakub},
article_location = {CAMBRIDGE},
article_number = {4},
doi = {http://dx.doi.org/10.1039/d3en00790a},
keywords = {LIPID CARRIERS NLC; DRUG-RELEASE; DEPLETION STABILIZATION; NANOPARTICLES; SYSTEMS; HERBICIDE; DIALYSIS; EXPOSURE; SALT},
language = {eng},
issn = {2051-8153},
journal = {Environmental Science: Nano},
title = {Release and stability of two tebuconazole nanoformulations in different aquatic media},
url = {https://pubs.rsc.org/en/content/articlelanding/2024/en/d3en00790a},
volume = {11},
year = {2024}
}
TY - JOUR
ID - 2421960
AU - López Cabeza, María del Rocío - Eghbalinejad, Mahleh - Kah, Melanie - Grillo, Renato - Hochmanová, Zuzana - Kotouček, Jan - Hofman, Jakub
PY - 2024
TI - Release and stability of two tebuconazole nanoformulations in different aquatic media
JF - Environmental Science: Nano
VL - 11
IS - 4
SP - 1612-1621
EP - 1612-1621
PB - ROYAL SOC CHEMISTRY
SN - 20518153
KW - LIPID CARRIERS NLC
KW - DRUG-RELEASE
KW - DEPLETION STABILIZATION
KW - NANOPARTICLES
KW - SYSTEMS
KW - HERBICIDE
KW - DIALYSIS
KW - EXPOSURE
KW - SALT
UR - https://pubs.rsc.org/en/content/articlelanding/2024/en/d3en00790a
N2 - Novel formulations for pesticides based on nano-sized carriers loaded with active substances (i.e., nanopesticides) have been developed in recent years to enhance the technical, environmental, and toxicological properties of pesticides. However, more information is needed to know about the behavior of nanopesticides in media used for ecotoxicological tests. In this work, the release and stability of two tebuconazole (TBZ) nanoformulations (TBZ loaded into poly-epsilon-caprolactone [PCL] or into nano-lipids [NLC]) were evaluated in Milli-Q water (control) and two media used broadly in ecotoxicological tests: reconstituted water (RCW) and Elendt M7 solution. The results suggested that the release of TBZ depended mainly on the TBZ concentration in the system with faster release at lower concentration levels. TBZ release was also influenced by the type of nanocarrier. For instance, for RCW and concentration of 50 mu g mL-1, TBZ release from NLC (plateau% = 44.7 +/- 2.6) was higher than from PCL (plateau% = 17.8 +/- 2.6). Similar trends were also found for other concentrations and the other medium, M7. The colloidal stability of the nanoformulations declined as the concentration of the stabilizing agents decreased. Our results show that it is essential to consider the factors that could influence both the release and stability of the nanopesticides in ecotoxicological media since these phenomena can affect the exposure of organisms to pesticides and, therefore, the results of ecotoxicological tests.
ER -
LÓPEZ CABEZA, María del Rocío, Mahleh EGHBALINEJAD, Melanie KAH, Renato GRILLO, Zuzana HOCHMANOVÁ, Jan KOTOUČEK a Jakub HOFMAN. Release and stability of two tebuconazole nanoformulations in different aquatic media. \textit{Environmental Science: Nano}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2024, roč.~11, č.~4, s.~1612-1621. ISSN~2051-8153. Dostupné z: https://dx.doi.org/10.1039/d3en00790a.
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