Predictors of spontaneous intracerebral hemorrhage mortality: a
community-based study in Brno, Czech Republic

J 2024

Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR et. al.

Základní údaje

Originální název

Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic

Autoři

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR, Petra CIMFLOVÁ, Miroslav ZVOLSKY, Silvie BELASKOVA, Ingrid KOVACOVA, Josef BEDNAŘÍK a Robert MIKULÍK

Vydání

Acta Neurologica Belgica, Heidelberg, Springer Heidelberg, 2024, 0300-9009

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.700 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s13760-024-02612-y

UT WoS

001284655800001

Klíčová slova anglicky

Czech Republic; Intracerebral hemorrhage; Mortality; Community-based study

Štítky

14110127, 14110132, 14110211, 14110221

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 8. 2024 10:53, Mgr. Tereza Miškechová

Anotace

V originále

Background and objective Intracerebral hemorrhage (ICH) is a serious medical condition with high mortality. However, factors leading to long-term mortality after ICH are largely unclear. The aim of this community-based study is to assess predictors of long-term mortality after spontaneous ICH. Methods We identified all patients admitted with spontaneous ICH to hospitals with a certified stroke unit in Brno, the second largest city in the Czech Republic (CR), in 2011, the year of the Czech Population and Housing Census. We reviewed their medical records for risk factors, radiographic parameters, and measures of post-stroke neurological deficit [National Institutes of Health Stroke Scale (NIHSS)]. Using the dates of death from the Czech National Mortality Register, we calculated mortality at 30 days, six months, one year, and three years after the ICH. Multivariate analysis with forward stepwise logistic regression was performed to determine independent predictors of mortality (p < 0.05). Results In 2011, 1086 patients with stroke were admitted to the four stroke-certified hospitals in Brno, CR. Of these, 134 had spontaneous ICH, with complete data available in 93 of them entering the final analysis. The mortality at 30 days, 6 months, 1 year, and 3 years post-ICH was 34%, 47%, 51%, and 63%, respectively. The mortality was highest in the first few days post-event, with 50% of patients dying in 255 days and average survival being 884 +/- 90 days. Both NIHSS and modified ICH (MICH) score showed to be strong and reliable predictors of short- as well as long-term mortality; the risk of death post-ICH increased with older age and size of ICH. Other risk factors contributing to higher, primarily shorter-term mortality included history of cardiac failure, myocardial infarction, or atrial fibrillation. Conclusions In our community-based study, we found that severity of neurological deficit at admission (NIHSS), combined with age and size of ICH, well predicted short- as well as long-term mortality after spontaneous ICH. A history of cardiac failure, myocardial infarction, or atrial fibrillation at presentation were also predictors of mortality, underscoring the need for optimal cardiac management in patients with ICH.

Návaznosti

LM2018128, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Český národní uzel Evropské sítě infrastruktur klinického výzkumu (CZECRIN)

NW24-09-00215, projekt VaV

Název: Analýza velkých dat pro záchranu životů pacientů s akutním infarktem myokardu a cévní mozkovou příhodou v České republice (MISA-BID Myocardial Infarction and Stroke Big Data Analysis)

Investor: Ministerstvo zdravotnictví ČR, Analýza velkých dat pro záchranu životů pacientů s akutním infarktem myokardu a cévní mozkovou příhodou v České republice (MISA-BID Myocardial Infarction and Stroke Big Data Analysis), Podprogram 1 - standardní

Citovat

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR, Petra CIMFLOVÁ, Miroslav ZVOLSKY, Silvie BELASKOVA, Ingrid KOVACOVA, Josef BEDNAŘÍK a Robert MIKULÍK. Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic. Acta Neurologica Belgica. Heidelberg: Springer Heidelberg, 2024, 14 s. ISSN 0300-9009. Dostupné z: https://dx.doi.org/10.1007/s13760-024-02612-y.

@article{2422975,
   author = {Štěrba, Albert and Šedová, Petra and Brown Jr, Robert D and Stehlík, Albert and Bryndziar, Tomáš and Cimflová, Petra and Zvolsky, Miroslav and Belaskova, Silvie and Kovacova, Ingrid and Bednařík, Josef and Mikulík, Robert},
   article_location = {Heidelberg},
   doi = {http://dx.doi.org/10.1007/s13760-024-02612-y},
   keywords = {Czech Republic; Intracerebral hemorrhage; Mortality; Community-based study},
   language = {eng},
   issn = {0300-9009},
   journal = {Acta Neurologica Belgica},
   title = {Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic},
   url = {https://link.springer.com/article/10.1007/s13760-024-02612-y},
   year = {2024}
}

TY  - JOUR
ID  - 2422975
AU  - Štěrba, Albert - Šedová, Petra - Brown Jr, Robert D - Stehlík, Albert - Bryndziar, Tomáš - Cimflová, Petra - Zvolsky, Miroslav - Belaskova, Silvie - Kovacova, Ingrid - Bednařík, Josef - Mikulík, Robert
PY  - 2024
TI  - Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic
JF  - Acta Neurologica Belgica
PB  - Springer Heidelberg
SN  - 03009009
KW  - Czech Republic
KW  - Intracerebral hemorrhage
KW  - Mortality
KW  - Community-based study
UR  - https://link.springer.com/article/10.1007/s13760-024-02612-y
N2  - Background and objective Intracerebral hemorrhage (ICH) is a serious medical condition with high mortality. However, factors leading to long-term mortality after ICH are largely unclear. The aim of this community-based study is to assess predictors of long-term mortality after spontaneous ICH. Methods We identified all patients admitted with spontaneous ICH to hospitals with a certified stroke unit in Brno, the second largest city in the Czech Republic (CR), in 2011, the year of the Czech Population and Housing Census. We reviewed their medical records for risk factors, radiographic parameters, and measures of post-stroke neurological deficit [National Institutes of Health Stroke Scale (NIHSS)]. Using the dates of death from the Czech National Mortality Register, we calculated mortality at 30 days, six months, one year, and three years after the ICH. Multivariate analysis with forward stepwise logistic regression was performed to determine independent predictors of mortality (p < 0.05). Results In 2011, 1086 patients with stroke were admitted to the four stroke-certified hospitals in Brno, CR. Of these, 134 had spontaneous ICH, with complete data available in 93 of them entering the final analysis. The mortality at 30 days, 6 months, 1 year, and 3 years post-ICH was 34%, 47%, 51%, and 63%, respectively. The mortality was highest in the first few days post-event, with 50% of patients dying in 255 days and average survival being 884 +/- 90 days. Both NIHSS and modified ICH (MICH) score showed to be strong and reliable predictors of short- as well as long-term mortality; the risk of death post-ICH increased with older age and size of ICH. Other risk factors contributing to higher, primarily shorter-term mortality included history of cardiac failure, myocardial infarction, or atrial fibrillation. Conclusions In our community-based study, we found that severity of neurological deficit at admission (NIHSS), combined with age and size of ICH, well predicted short- as well as long-term mortality after spontaneous ICH. A history of cardiac failure, myocardial infarction, or atrial fibrillation at presentation were also predictors of mortality, underscoring the need for optimal cardiac management in patients with ICH.
ER  -

ŠTĚRBA, Albert, Petra ŠEDOVÁ, Robert D BROWN JR, Albert STEHLÍK, Tomáš BRYNDZIAR, Petra CIMFLOVÁ, Miroslav ZVOLSKY, Silvie BELASKOVA, Ingrid KOVACOVA, Josef BEDNAŘÍK a Robert MIKULÍK. Predictors of spontaneous intracerebral hemorrhage mortality: a community-based study in Brno, Czech Republic. \textit{Acta Neurologica Belgica}. Heidelberg: Springer Heidelberg, 2024, 14 s. ISSN~0300-9009. Dostupné z: https://dx.doi.org/10.1007/s13760-024-02612-y.

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