Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study

SALMANTON-GARCIA, Jon, Oliver A CORNELY, Jannik STEMLER, Aleksandra BARAC, Joerg STEINMANN, Alena SIVÁKOVÁ, Emin Halis AKALIN, Sevtap ARIKAN-AKDAGLII, Laura LOUGHLINJ, Cristina TOSCANO, Manjusha NARAYANAN, Benedict ROGERS, Birgit WILLINGER, Deniz AKYOL, Emmanuel ROILIDES, Katrien LAGROU, Malgorzata MIKULSKA, Blandine DENIS, Diane PONSCARME, Urlike SCHARMANN, Alpay AZAP, Deborah LOCKHART, Tihana BICANICY, Florian KRON, Nurettin ERBEN, Riina RAUTEMAA-RICHARDSON, Anna L GOODMAN, Carolina GARCIA-VIDAL, Cornelia LASS-FLOERL, Jean-Pierre GANGNEUX, Lucia TARAMASSO, Maite RUIZ, Yael SCHICK, Van Wijngaerden ERIC, Christopher MILACEK, Daniele Roberto GIACOBBE, Clare LOGANY, Emily ROONEY, Andrea GORI, Murat AKOVA, Matteo BASSETTI, Martin HOENIGL a Philipp KOEHLER. Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study. JOURNAL OF INFECTION. LONDON: W B SAUNDERS CO LTD, 2024, roč. 89, č. 3, s. 1-10. ISSN 0163-4453. Dostupné z: https://dx.doi.org/10.1016/j.jinf.2024.106229.

Základní údaje

• Originální název: Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study
• Autoři: SALMANTON-GARCIA, Jon, Oliver A CORNELY, Jannik STEMLER, Aleksandra BARAC, Joerg STEINMANN, Alena SIVÁKOVÁ (203 Česká republika, domácí), Emin Halis AKALIN, Sevtap ARIKAN-AKDAGLII, Laura LOUGHLINJ, Cristina TOSCANO, Manjusha NARAYANAN, Benedict ROGERS, Birgit WILLINGER, Deniz AKYOL, Emmanuel ROILIDES, Katrien LAGROU, Malgorzata MIKULSKA, Blandine DENIS, Diane PONSCARME, Urlike SCHARMANN, Alpay AZAP, Deborah LOCKHART, Tihana BICANICY, Florian KRON, Nurettin ERBEN, Riina RAUTEMAA-RICHARDSON, Anna L GOODMAN, Carolina GARCIA-VIDAL, Cornelia LASS-FLOERL, Jean-Pierre GANGNEUX, Lucia TARAMASSO, Maite RUIZ, Yael SCHICK, Van Wijngaerden ERIC, Christopher MILACEK, Daniele Roberto GIACOBBE, Clare LOGANY, Emily ROONEY, Andrea GORI, Murat AKOVA, Matteo BASSETTI, Martin HOENIGL a Philipp KOEHLER.
• Vydání: JOURNAL OF INFECTION, LONDON, W B SAUNDERS CO LTD, 2024, 0163-4453.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30303 Infectious Diseases
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 28.200 v roce 2022
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1016/j.jinf.2024.106229
• UT WoS: 001285560400001
• Klíčová slova anglicky: Candidaemia; Mortality; Epidemiology; Risk factors; Candida; Hospitalization
• Štítky: 14110113, rivok
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Introduction: Despite antifungal advancements, candidaemia still has a high mortality rate of up to 40%. The ECMM Candida III study in Europe investigated the changing epidemiology and outcomes of candidaemia for better understanding and management of these infections. Methods: In this observational cohort study, participating hospitals enrolled the first ten consecutive adults with blood culture-proven candidemia. Collected data included patient demographics, risk factors, hospital stay duration (follow-up of 90 days), diagnostic procedures, causative Candida spp., management details, and outcome. Controls were included in a 1:1 fashion from the same hospitals. The matching process ensured similarity in age (10-year range), primary underlying disease, hospitalization in intensive care versus non-ICU ward, and major surgery within 2 weeks before candidemia between cases and controls. Overall and attributable mortality were described, and a survival probability for cases and controls was performed. Results: One hundred seventy-one pairs consisting of patients with candidemia and matched controls from 28 institutions were included. In those with candidemia, overall mortality was 40.4%. Attributable mortality was 18.1% overall but differed between causative Candida species (7.7% for Candida albicans, , 23.7% for Candida glabrata/Nakaseomyces glabratus, , 7.7% for Candida parapsilosis and 63.6% for Candida tropicalis). ). Regarding risk factors, the presence of a central venous catheter, total parenteral nutrition and acute or chronic renal disease were significantly more common in cases versus controls. Duration of hospitalization, and especially that of ICU stay, was significantly longer in candidemia cases (20 (IQR 10-33) vs 15 days (IQR 7-28); p = 0.004). Conclusions: Although overall and attributable mortality in this subgroup analysis of matched case/control pairs remains high, the attributable mortality appears to have decreased in comparison to historical cohorts. This decrease may be driven by improved prognosis of Candida albicans and Candida parapsilosis candidemia; whereas candidemia due to other Candida spp. exhibits a much higher attributable mortality. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).