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@article{2423137, author = {SalmantonandGarcia, Jon and Cornely, Oliver A and Stemler, Jannik and Barac, Aleksandra and Steinmann, Joerg and Siváková, Alena and Akalin, Emin Halis and ArikanandAkdaglii, Sevtap and Loughlinj, Laura and Toscano, Cristina and Narayanan, Manjusha and Rogers, Benedict and Willinger, Birgit and Akyol, Deniz and Roilides, Emmanuel and Lagrou, Katrien and Mikulska, Malgorzata and Denis, Blandine and Ponscarme, Diane and Scharmann, Urlike and Azap, Alpay and Lockhart, Deborah and Bicanicy, Tihana and Kron, Florian and Erben, Nurettin and RautemaaandRichardson, Riina and Goodman, Anna L and GarciaandVidal, Carolina and LassandFloerl, Cornelia and Gangneux, JeanandPierre and Taramasso, Lucia and Ruiz, Maite and Schick, Yael and Eric, Van Wijngaerden and Milacek, Christopher and Giacobbe, Daniele Roberto and Logany, Clare and Rooney, Emily and Gori, Andrea and Akova, Murat and Bassetti, Matteo and Hoenigl, Martin and Koehler, Philipp}, article_location = {LONDON}, article_number = {3}, doi = {http://dx.doi.org/10.1016/j.jinf.2024.106229}, keywords = {Candidaemia; Mortality; Epidemiology; Risk factors; Candida; Hospitalization}, language = {eng}, issn = {0163-4453}, journal = {JOURNAL OF INFECTION}, title = {Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study}, url = {https://www.sciencedirect.com/science/article/pii/S0163445324001634?via%3Dihub}, volume = {89}, year = {2024} }
TY - JOUR ID - 2423137 AU - Salmanton-Garcia, Jon - Cornely, Oliver A - Stemler, Jannik - Barac, Aleksandra - Steinmann, Joerg - Siváková, Alena - Akalin, Emin Halis - Arikan-Akdaglii, Sevtap - Loughlinj, Laura - Toscano, Cristina - Narayanan, Manjusha - Rogers, Benedict - Willinger, Birgit - Akyol, Deniz - Roilides, Emmanuel - Lagrou, Katrien - Mikulska, Malgorzata - Denis, Blandine - Ponscarme, Diane - Scharmann, Urlike - Azap, Alpay - Lockhart, Deborah - Bicanicy, Tihana - Kron, Florian - Erben, Nurettin - Rautemaa-Richardson, Riina - Goodman, Anna L - Garcia-Vidal, Carolina - Lass-Floerl, Cornelia - Gangneux, Jean-Pierre - Taramasso, Lucia - Ruiz, Maite - Schick, Yael - Eric, Van Wijngaerden - Milacek, Christopher - Giacobbe, Daniele Roberto - Logany, Clare - Rooney, Emily - Gori, Andrea - Akova, Murat - Bassetti, Matteo - Hoenigl, Martin - Koehler, Philipp PY - 2024 TI - Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study JF - JOURNAL OF INFECTION VL - 89 IS - 3 SP - 1-10 EP - 1-10 PB - W B SAUNDERS CO LTD SN - 01634453 KW - Candidaemia KW - Mortality KW - Epidemiology KW - Risk factors KW - Candida KW - Hospitalization UR - https://www.sciencedirect.com/science/article/pii/S0163445324001634?via%3Dihub N2 - Introduction: Despite antifungal advancements, candidaemia still has a high mortality rate of up to 40%. The ECMM Candida III study in Europe investigated the changing epidemiology and outcomes of candidaemia for better understanding and management of these infections. Methods: In this observational cohort study, participating hospitals enrolled the first ten consecutive adults with blood culture-proven candidemia. Collected data included patient demographics, risk factors, hospital stay duration (follow-up of 90 days), diagnostic procedures, causative Candida spp., management details, and outcome. Controls were included in a 1:1 fashion from the same hospitals. The matching process ensured similarity in age (10-year range), primary underlying disease, hospitalization in intensive care versus non-ICU ward, and major surgery within 2 weeks before candidemia between cases and controls. Overall and attributable mortality were described, and a survival probability for cases and controls was performed. Results: One hundred seventy-one pairs consisting of patients with candidemia and matched controls from 28 institutions were included. In those with candidemia, overall mortality was 40.4%. Attributable mortality was 18.1% overall but differed between causative Candida species (7.7% for Candida albicans, , 23.7% for Candida glabrata/Nakaseomyces glabratus, , 7.7% for Candida parapsilosis and 63.6% for Candida tropicalis). ). Regarding risk factors, the presence of a central venous catheter, total parenteral nutrition and acute or chronic renal disease were significantly more common in cases versus controls. Duration of hospitalization, and especially that of ICU stay, was significantly longer in candidemia cases (20 (IQR 10-33) vs 15 days (IQR 7-28); p = 0.004). Conclusions: Although overall and attributable mortality in this subgroup analysis of matched case/control pairs remains high, the attributable mortality appears to have decreased in comparison to historical cohorts. This decrease may be driven by improved prognosis of Candida albicans and Candida parapsilosis candidemia; whereas candidemia due to other Candida spp. exhibits a much higher attributable mortality. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ER -
SALMANTON-GARCIA, Jon, Oliver A CORNELY, Jannik STEMLER, Aleksandra BARAC, Joerg STEINMANN, Alena SIVÁKOVÁ, Emin Halis AKALIN, Sevtap ARIKAN-AKDAGLII, Laura LOUGHLINJ, Cristina TOSCANO, Manjusha NARAYANAN, Benedict ROGERS, Birgit WILLINGER, Deniz AKYOL, Emmanuel ROILIDES, Katrien LAGROU, Malgorzata MIKULSKA, Blandine DENIS, Diane PONSCARME, Urlike SCHARMANN, Alpay AZAP, Deborah LOCKHART, Tihana BICANICY, Florian KRON, Nurettin ERBEN, Riina RAUTEMAA-RICHARDSON, Anna L GOODMAN, Carolina GARCIA-VIDAL, Cornelia LASS-FLOERL, Jean-Pierre GANGNEUX, Lucia TARAMASSO, Maite RUIZ, Yael SCHICK, Van Wijngaerden ERIC, Christopher MILACEK, Daniele Roberto GIACOBBE, Clare LOGANY, Emily ROONEY, Andrea GORI, Murat AKOVA, Matteo BASSETTI, Martin HOENIGL a Philipp KOEHLER. Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study. \textit{JOURNAL OF INFECTION}. LONDON: W B SAUNDERS CO LTD, 2024, roč.~89, č.~3, s.~1-10. ISSN~0163-4453. Dostupné z: https://dx.doi.org/10.1016/j.jinf.2024.106229.
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