Clear surgical margins as a prognostic indicator for disease
recurrence, with no impact on survival rates in patients with
myxofibrosarcoma

J 2024

Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma

TOMÁŠ, Tomáš, Vasileios APOSTOLOPOULOS, Lukáš PAZOUREK, Marian KUBÍČEK, Iva ZAMBO et. al.

Základní údaje

Originální název

Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma

Autoři

TOMÁŠ, Tomáš (203 Česká republika, domácí), Vasileios APOSTOLOPOULOS (203 Česká republika, domácí), Lukáš PAZOUREK (203 Česká republika, domácí), Marian KUBÍČEK (203 Česká republika, domácí), Iva ZAMBO (203 Česká republika, domácí), Dagmar ADÁMKOVÁ (203 Česká republika, domácí), Pavel ŠLAMPA (203 Česká republika, domácí) a Michal MAHDAL (203 Česká republika, domácí)

Vydání

Scientific Reports, London, NATURE RESEARCH, 2024, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-024-63035-6

UT WoS

001234681100016

Klíčová slova anglicky

myxofibrosarcoma

Štítky

14110112, 14110123, 14110811, 14110812, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 8. 2024 12:19, Mgr. Tereza Miškechová

Anotace

V originále

Myxofibrosarcoma presents an infiltrating growth pattern that results in a high tendency for local recurrence. Clear margin resection is challenging because of microscopic infiltration. The purpose of the present study was to analyze the overall and disease-free survival rates of patients with myxofibrosarcoma and the prognostic factors that determine both survival and disease recurrence. Among the 111 patients included in our study, the 5-year overall survival rate was 65.5%. An age of more than 65 years (hazard ratio [HR] 1.9 [95% confidence interval (CI) 1.4-5.6]; p < 0.001), a tumor size of more than 5 cm (HR 2.8 [95% CI 0.9-8.1]; p = 0.049) and the G3 tumor grade (HR 14.1 [95% CI 2.1-105.0]; p < 0.001) negatively affected overall survival. The 5-year recurrence-free survival rate was 49.4%. R1/R2-type resection (HR 2.4 [95% CI 1.0-5.6]; p = 0.048) had a detrimental effect on tumor recurrence. Clear margins had a positive impact on recurrence-free survival, but did not significantly affect overall patient survival, suggesting that other factors may play a more significant role in determining patient outcomes. A surgical margin of 2 mm was not sufficient to significantly influence the incidence of recurrence. Consequently, a wider surgical margin may be necessary to reduce the risk of myxofibrosarcoma recurrence.

Citovat

TOMÁŠ, Tomáš, Vasileios APOSTOLOPOULOS, Lukáš PAZOUREK, Marian KUBÍČEK, Iva ZAMBO, Dagmar ADÁMKOVÁ, Pavel ŠLAMPA a Michal MAHDAL. Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma. Scientific Reports. London: NATURE RESEARCH, 2024, roč. 14, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-024-63035-6.

@article{2423184,
   author = {Tomáš, Tomáš and Apostolopoulos, Vasileios and Pazourek, Lukáš and Kubíček, Marian and Zambo, Iva and Adámková, Dagmar and Šlampa, Pavel and Mahdal, Michal},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-024-63035-6},
   keywords = {myxofibrosarcoma},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma},
   url = {https://www.nature.com/articles/s41598-024-63035-6},
   volume = {14},
   year = {2024}
}

TY  - JOUR
ID  - 2423184
AU  - Tomáš, Tomáš - Apostolopoulos, Vasileios - Pazourek, Lukáš - Kubíček, Marian - Zambo, Iva - Adámková, Dagmar - Šlampa, Pavel - Mahdal, Michal
PY  - 2024
TI  - Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma
JF  - Scientific Reports
VL  - 14
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE RESEARCH
SN  - 20452322
KW  - myxofibrosarcoma
UR  - https://www.nature.com/articles/s41598-024-63035-6
N2  - Myxofibrosarcoma presents an infiltrating growth pattern that results in a high tendency for local recurrence. Clear margin resection is challenging because of microscopic infiltration. The purpose of the present study was to analyze the overall and disease-free survival rates of patients with myxofibrosarcoma and the prognostic factors that determine both survival and disease recurrence. Among the 111 patients included in our study, the 5-year overall survival rate was 65.5%. An age of more than 65 years (hazard ratio [HR] 1.9 [95% confidence interval (CI) 1.4-5.6]; p < 0.001), a tumor size of more than 5 cm (HR 2.8 [95% CI 0.9-8.1]; p = 0.049) and the G3 tumor grade (HR 14.1 [95% CI 2.1-105.0]; p < 0.001) negatively affected overall survival. The 5-year recurrence-free survival rate was 49.4%. R1/R2-type resection (HR 2.4 [95% CI 1.0-5.6]; p = 0.048) had a detrimental effect on tumor recurrence. Clear margins had a positive impact on recurrence-free survival, but did not significantly affect overall patient survival, suggesting that other factors may play a more significant role in determining patient outcomes. A surgical margin of 2 mm was not sufficient to significantly influence the incidence of recurrence. Consequently, a wider surgical margin may be necessary to reduce the risk of myxofibrosarcoma recurrence.
ER  -

TOMÁŠ, Tomáš, Vasileios APOSTOLOPOULOS, Lukáš PAZOUREK, Marian KUBÍČEK, Iva ZAMBO, Dagmar ADÁMKOVÁ, Pavel ŠLAMPA a Michal MAHDAL. Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma. \textit{Scientific Reports}. London: NATURE RESEARCH, 2024, roč.~14, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-024-63035-6.

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