| TOMÁŠ, Tomáš, Vasileios APOSTOLOPOULOS, Lukáš PAZOUREK, Marian KUBÍČEK, Iva ZAMBO, Dagmar ADÁMKOVÁ, Pavel ŠLAMPA a Michal MAHDAL. Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma. Scientific Reports. London: NATURE RESEARCH, 2024, roč. 14, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-024-63035-6. |
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@article{2423184,
author = {Tomáš, Tomáš and Apostolopoulos, Vasileios and Pazourek, Lukáš and Kubíček, Marian and Zambo, Iva and Adámková, Dagmar and Šlampa, Pavel and Mahdal, Michal},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-024-63035-6},
keywords = {myxofibrosarcoma},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma},
url = {https://www.nature.com/articles/s41598-024-63035-6},
volume = {14},
year = {2024}
}
TY - JOUR
ID - 2423184
AU - Tomáš, Tomáš - Apostolopoulos, Vasileios - Pazourek, Lukáš - Kubíček, Marian - Zambo, Iva - Adámková, Dagmar - Šlampa, Pavel - Mahdal, Michal
PY - 2024
TI - Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma
JF - Scientific Reports
VL - 14
IS - 1
SP - 1-10
EP - 1-10
PB - NATURE RESEARCH
SN - 20452322
KW - myxofibrosarcoma
UR - https://www.nature.com/articles/s41598-024-63035-6
N2 - Myxofibrosarcoma presents an infiltrating growth pattern that results in a high tendency for local recurrence. Clear margin resection is challenging because of microscopic infiltration. The purpose of the present study was to analyze the overall and disease-free survival rates of patients with myxofibrosarcoma and the prognostic factors that determine both survival and disease recurrence. Among the 111 patients included in our study, the 5-year overall survival rate was 65.5%. An age of more than 65 years (hazard ratio [HR] 1.9 [95% confidence interval (CI) 1.4-5.6]; p < 0.001), a tumor size of more than 5 cm (HR 2.8 [95% CI 0.9-8.1]; p = 0.049) and the G3 tumor grade (HR 14.1 [95% CI 2.1-105.0]; p < 0.001) negatively affected overall survival. The 5-year recurrence-free survival rate was 49.4%. R1/R2-type resection (HR 2.4 [95% CI 1.0-5.6]; p = 0.048) had a detrimental effect on tumor recurrence. Clear margins had a positive impact on recurrence-free survival, but did not significantly affect overall patient survival, suggesting that other factors may play a more significant role in determining patient outcomes. A surgical margin of 2 mm was not sufficient to significantly influence the incidence of recurrence. Consequently, a wider surgical margin may be necessary to reduce the risk of myxofibrosarcoma recurrence.
ER -
TOMÁŠ, Tomáš, Vasileios APOSTOLOPOULOS, Lukáš PAZOUREK, Marian KUBÍČEK, Iva ZAMBO, Dagmar ADÁMKOVÁ, Pavel ŠLAMPA a Michal MAHDAL. Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma. \textit{Scientific Reports}. London: NATURE RESEARCH, 2024, roč.~14, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-024-63035-6.
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