SENECA study: staging endometrial cancer based on molecular
classification

J 2024

SENECA study: staging endometrial cancer based on molecular classification

CHACON, Enrique, Felix BORIA, R Rajagopalan LYER, Francesco FANFANI, Mario MALZONI et. al.

Základní údaje

Originální název

SENECA study: staging endometrial cancer based on molecular classification

Autoři

CHACON, Enrique, Felix BORIA, R Rajagopalan LYER, Francesco FANFANI, Mario MALZONI, Petra BRETOVÁ, Ana Luzarraga AZNAR, Robert FRUSCIO, Marcin A JEDRYKA, Richard TÓTH, Anna Myriam PERRONE, Athanasios KAKKOS, Ignacio Cristóbal QUEVEDO, Luigi CONGEDO, Vanna ZANAGNOLO, Sergi FERNANDEZ-GONZALEZ, Beatriz FERRO, Fabrice NARDUCCI, Tatevik HOVHANNISYAN, Elif AKSAHIN, Laura CARDENAS, M Reyes OLIVER, Gonzalo NOZALEDA, Marta ARNAEZ, Marcin MISIEK, Annamaria FERRERO, Flore Anne PAIN, Janire ZARRAGOITIA, Cristina DIAZ, Lorenzo CEPPI, Shamsi MEHDIYEV, Fernando ROLDÁN-RIVAS, Alberto Rafael GUIJARRO-CAMPILLO, Joana AMENGUAL, Nabil MANZOUR, Luisa Sanchez LORENZO, Jorge M NÚÑEZ-CÓRDOBA a Antonio Gonzalez MA

Vydání

International journal of gynecological cancer, LONDON, BMJ PUBLISHING GROUP, 2024, 1048-891X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.800 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1136/ijgc-2024-005711

Změněno: 22. 8. 2024 08:35, Mgr. Tereza Miškechová

Anotace

V originále

Objective Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups is essential. To evaluate SLN involvement in early-stage (International Federation of Gynecology and Obstetrics 2009 I–II) endometrial cancer, considering molecular subtypes and new European Society of Gynaecological Oncology (ESGO) risk classification. Methods The SENECA study retrospectively reviewed data from 2139 women with stage I–II endometrial cancer across 66 centers in 16 countries. Patients underwent surgery with SLN assessment following ESGO guidelines between January 2021 and December 2022. Molecular analysis was performed on pre-operative biopsies or hysterectomy specimens. Results Among the 2139 patients, the molecular subgroups were as follows: 272 (12.7%) p53 abnormal (p53abn, 1191 (55.7%) non-specific molecular profile (NSMP), 581 (27.2%) mismatch repair deficient (MMRd), 95 (4.4%) POLE mutated (POLE-mut). Tracer diffusion was detected in, at least one side, in 97.2% of the cases; with a bilateral diffusion observed in 82.7% of the cases. By ultrastaging (90.7% of the cases) or one-step nucleic acid amplification (198 (9.3%) of the cases), 205 patients were identified with affected sentinel lymph nodes, representing 9.6% of the sample. Of these, 139 (67.8%) had low-volume metastases (including micrometastases, 42.9%; and isolated tumor cells, 24.9%) while 66 (32.2%) had macrometastases. Significant differences in SLN involvement were observed between molecular subtypes, with p53abn and MMRd groups having the highest rates (12.50% and 12.40%, respectively) compared with NSMP (7.80%) and POLE-mut (6.30%), (p=0.004); (p53abn, OR=1.69 (95% CI 1.11 to 2.56), p=0.014; MMRd, OR=1.67 (95% CI 1.21 to 2.31), p=0.002). Differences were also noted among ESGO risk groups (2.84% for low-risk patients, 6.62% for intermediate-risk patients, 21.63% for high–intermediate risk patients, and 22.51% for high-risk patients; p<0.001). Conclusions Our study reveals significant differences in SLN involvement among patients with early-stage endometrial cancer based on molecular subtypes. This underscores the importance of considering molecular characteristics for accurate staging and optimal management decisions.

Citovat

@article{2424418,
   author = {Chacon, Enrique and Boria, Felix and Lyer, R Rajagopalan and Fanfani, Francesco and Malzoni, Mario and Bretová, Petra and Aznar, Ana Luzarraga and Fruscio, Robert and Jedryka, Marcin A and Tóth, Richard and Perrone, Anna Myriam and Kakkos, Athanasios and Quevedo, Ignacio Cristóbal and Congedo, Luigi and Zanagnolo, Vanna and FernandezandGonzalez, Sergi and Ferro, Beatriz and Narducci, Fabrice and Hovhannisyan, Tatevik and Aksahin, Elif and Cardenas, Laura and Oliver, M Reyes and Nozaleda, Gonzalo and Arnaez, Marta and Misiek, Marcin and Ferrero, Annamaria and Pain, Flore Anne and Zarragoitia, Janire and Diaz, Cristina and Ceppi, Lorenzo and Mehdiyev, Shamsi and RoldánandRivas, Fernando and GuijarroandCampillo, Alberto Rafael and Amengual, Joana and Manzour, Nabil and Lorenzo, Luisa Sanchez and NúñezandCórdoba, Jorge M and Ma, Antonio Gonzalez},
   article_location = {LONDON},
   doi = {http://dx.doi.org/10.1136/ijgc-2024-005711},
   language = {eng},
   issn = {1048-891X},
   journal = {International journal of gynecological cancer},
   note = {Bez afiliace k MU.},
   title = {SENECA study: staging endometrial cancer based on molecular classification},
   url = {https://ijgc.bmj.com/content/early/2024/08/15/ijgc-2024-005711.long},
   year = {2024}
}

TY  - JOUR
ID  - 2424418
AU  - Chacon, Enrique - Boria, Felix - Lyer, R Rajagopalan - Fanfani, Francesco - Malzoni, Mario - Bretová, Petra - Aznar, Ana Luzarraga - Fruscio, Robert - Jedryka, Marcin A - Tóth, Richard - Perrone, Anna Myriam - Kakkos, Athanasios - Quevedo, Ignacio Cristóbal - Congedo, Luigi - Zanagnolo, Vanna - Fernandez-Gonzalez, Sergi - Ferro, Beatriz - Narducci, Fabrice - Hovhannisyan, Tatevik - Aksahin, Elif - Cardenas, Laura - Oliver, M Reyes - Nozaleda, Gonzalo - Arnaez, Marta - Misiek, Marcin - Ferrero, Annamaria - Pain, Flore Anne - Zarragoitia, Janire - Diaz, Cristina - Ceppi, Lorenzo - Mehdiyev, Shamsi - Roldán-Rivas, Fernando - Guijarro-Campillo, Alberto Rafael - Amengual, Joana - Manzour, Nabil - Lorenzo, Luisa Sanchez - Núñez-Córdoba, Jorge M - Ma, Antonio Gonzalez
PY  - 2024
TI  - SENECA study: staging endometrial cancer based on molecular classification
JF  - International journal of gynecological cancer
PB  - BMJ PUBLISHING GROUP
SN  - 1048891X
N1  - Bez afiliace k MU.
UR  - https://ijgc.bmj.com/content/early/2024/08/15/ijgc-2024-005711.long
N2  - Objective Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups is essential. To evaluate SLN involvement in early-stage (International Federation of Gynecology and Obstetrics 2009 I–II) endometrial cancer, considering molecular subtypes and new European Society of Gynaecological Oncology (ESGO) risk classification. Methods The SENECA study retrospectively reviewed data from 2139 women with stage I–II endometrial cancer across 66 centers in 16 countries. Patients underwent surgery with SLN assessment following ESGO guidelines between January 2021 and December 2022. Molecular analysis was performed on pre-operative biopsies or hysterectomy specimens. Results Among the 2139 patients, the molecular subgroups were as follows: 272 (12.7%) p53 abnormal (p53abn, 1191 (55.7%) non-specific molecular profile (NSMP), 581 (27.2%) mismatch repair deficient (MMRd), 95 (4.4%) POLE mutated (POLE-mut). Tracer diffusion was detected in, at least one side, in 97.2% of the cases; with a bilateral diffusion observed in 82.7% of the cases. By ultrastaging (90.7% of the cases) or one-step nucleic acid amplification (198 (9.3%) of the cases), 205 patients were identified with affected sentinel lymph nodes, representing 9.6% of the sample. Of these, 139 (67.8%) had low-volume metastases (including micrometastases, 42.9%; and isolated tumor cells, 24.9%) while 66 (32.2%) had macrometastases. Significant differences in SLN involvement were observed between molecular subtypes, with p53abn and MMRd groups having the highest rates (12.50% and 12.40%, respectively) compared with NSMP (7.80%) and POLE-mut (6.30%), (p=0.004); (p53abn, OR=1.69 (95% CI 1.11 to 2.56), p=0.014; MMRd, OR=1.67 (95% CI 1.21 to 2.31), p=0.002). Differences were also noted among ESGO risk groups (2.84% for low-risk patients, 6.62% for intermediate-risk patients, 21.63% for high–intermediate risk patients, and 22.51% for high-risk patients; p<0.001). Conclusions Our study reveals significant differences in SLN involvement among patients with early-stage endometrial cancer based on molecular subtypes. This underscores the importance of considering molecular characteristics for accurate staging and optimal management decisions.
ER  -

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