2024
Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial
MANDEVILLE, Henry C, Gianni BISOGNO, Veronique MINARD-COLIN, Rita ALAGGIO, Myriam BEN-ARUSH et. al.Základní údaje
Originální název
Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial
Autoři
MANDEVILLE, Henry C, Gianni BISOGNO, Veronique MINARD-COLIN, Rita ALAGGIO, Myriam BEN-ARUSH, Cyrus CHARGARI, Beatrice COPPADORO, Ross CRAIGIE, Christine DEVALCK, Sima FERMAN, Andrea FERRARI, Heidi GLOSLI, Raquel Hladun ALVARO, Marinka HOL, Peter MÚDRY (203 Česká republika, domácí), Daniel ORBACH, Monica Ramos ALBIAC, Johannes H M MERKS a Meriel E M JENNEY
Vydání
Cancer, Hoboken, Wiley, 2024, 0008-543X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30204 Oncology
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 6.100 v roce 2023
Organizační jednotka
Lékařská fakulta
UT WoS
001278087300001
Klíčová slova anglicky
alkylator chemotherapy; pediatric sarcoma; radiotherapy; rhabdomyosarcoma; surgical resection
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 30. 1. 2025 12:24, Mgr. Tereza Miškechová
Anotace
V originále
Background: The authors report the prospective evaluation of reduced dose alkylator chemotherapy combined with radiotherapy for European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) standard risk nonalveolar rhabdomyosarcoma (NA-RMS). Patients and Methods: Localized node negative Intergroup Rhabdomyosarcoma Study (IRS) II/III NA-RMS at favorable sites (subgroup C), <25 years old, received five cycles of ifosfamide, vincristine, and dactinomycin (IVA) chemotherapy (30 g/m(2) ifosfamide) and four cycles of vincristine and dactinomycin (if receiving radiotherapy), or nine cycles of IVA (54 g/m(2) ifosfamide) +/- radiotherapy. Delayed primary tumor excision was considered for IRS III tumors. The primary end points were event-free survival (EFS) and overall survival (OS). Results: From October 2005 to December 2016, 359 evaluable patients were recruited: orbit, 164 (45.7%); head and neck nonparameningeal, 77 (21.4%); and genitourinary non-bladder/prostate, 118 (32.9%). EFS and OS were 77.4% (95% confidence interval [CI], 72.5-81.6) and 93.5% (95% CI, 90.1-95.8), respectively. Lower dose alkylator chemotherapy and radiotherapy achieved 5-year OS of 93.7% but the difference with higher dose alkylator chemotherapy +/- radiotherapy was not significant (p = 0.8003). Adjuvant radiotherapy improved EFS with 5-year estimates of 84.7% versus 65.2% for nonirradiated (p < .0001), but not OS (p = .9298). Omitting radiotherapy for orbital tumors reduced OS (5-year was 87.1% vs. 97.3% for irradiated, p = .0257). Following R0 resection (n = 60), radiotherapy did not significantly improve EFS or OS. Conclusions: Radiotherapy for local tumor control allows for reduction of cumulative dose of alkylators in EpSSG standard risk subgroup C RMS patients. The omission of radiotherapy did not affect OS in all patients except those with orbital RMS and was associated with inferior EFS.