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@article{2436018, author = {Wieclawski, Wiktor and Bielski, Krzysztof and Jáni, Martin and Binder, Marek and Adamczyk, Przemyslaw}, article_location = {CLARE}, article_number = {December 2024}, doi = {http://dx.doi.org/10.1016/j.pscychresns.2024.111883}, keywords = {Schizophrenia; fMRI; Somatomotor network; Cerebellum; Negative symptoms}, language = {eng}, issn = {0925-4927}, journal = {Psychiatry Research: Neuroimaging}, title = {Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia}, url = {https://www.sciencedirect.com/science/article/pii/S0925492724001069?via%3Dihub}, volume = {345}, year = {2024} }
TY - JOUR ID - 2436018 AU - Wieclawski, Wiktor - Bielski, Krzysztof - Jáni, Martin - Binder, Marek - Adamczyk, Przemyslaw PY - 2024 TI - Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia JF - Psychiatry Research: Neuroimaging VL - 345 IS - December 2024 SP - 1-6 EP - 1-6 PB - ELSEVIER IRELAND LTD SN - 09254927 KW - Schizophrenia KW - fMRI KW - Somatomotor network KW - Cerebellum KW - Negative symptoms UR - https://www.sciencedirect.com/science/article/pii/S0925492724001069?via%3Dihub N2 - Recent fMRI resting-state findings show aberrant functional connectivity within somatomotor network (SMN) in schizophrenia. Moreover, functional connectivity aberrations of the motor system are often reported to be related to the severity of psychotic symptoms. Thus, it is important to validate those findings and confirm their relationship with psychopathology. Therefore, we decided to take an entirely data-driven approach in our fMRI resting-state study of 30 chronic schizophrenia outpatients and 30 matched control subjects. We used independent component analysis (ICA), dual regression, and seed-based connectivity analysis. We found reduced functional connectivity within SMN in schizophrenia patients compared to controls and SMN hypoconnectivity with the cerebellum in schizophrenia patients. The latter was strongly correlated with the severity of alogia, one of the main psychotic symptoms, i.e. poverty of speech and reduction in spontaneous speech,. Our results are consistent with the recent knowledge about the role of the cerebellum in cognitive functioning and its abnormalities in psychiatric disorders, e.g. schizophrenia. In conclusion, the presented results, for the first time clearly showed the involvement of the cerebellum hypoconnectivity with SMN in the persistence and severity of alogia symptoms in schizophrenia. ER -
WIECLAWSKI, Wiktor, Krzysztof BIELSKI, Martin JÁNI, Marek BINDER a Przemyslaw ADAMCZYK. Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia. \textit{Psychiatry Research: Neuroimaging}. CLARE: ELSEVIER IRELAND LTD, 2024, roč.~345, December 2024, s.~1-6. ISSN~0925-4927. Dostupné z: https://dx.doi.org/10.1016/j.pscychresns.2024.111883.
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