Subjective visual sensitivity in neurotypical adults: insights
from a magnetic resonance spectroscopy study

J 2024

Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study

JURKOVIČOVÁ, Lenka; Julie PÁLENÍK; Petr KUDLIČKA; Lenka SAKÁLOŠOVÁ; Alexandra RUŽIČKOVÁ et al.

Základní údaje

Originální název

Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study

Autoři

Vydání

FRONTIERS IN NEUROSCIENCE, SWITZERLAND, FRONTIERS MEDIA SA, 2024, 1662-453X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.200

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00137257

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Pattern Glare Test; visual discomfort; magnetic resonance spectroscopy; GABA; glutamate; cortical excitability

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 3. 2025 18:33, Mgr. Eva Dubská

Anotace

V originále

Introduction: Altered subjective visual sensitivity manifests as feelings of discomfort or overload elicited by intense and irritative visual stimuli. This can result in a host of visual aberrations including visual distortions, elementary visual hallucinations and visceral responses like dizziness and nausea, collectively referred to as “pattern glare.” Current knowledge of the underlying neural mechanisms has focused on overall excitability of the visual cortex, but the individual contribution of excitatory and inhibitory systems has not yet been quantified. Methods: In this study, we focus on the role of glutamate and γ-aminobutyric acid (GABA) as potential mediators of individual differences in subjective visual sensitivity, measured by a computerized Pattern Glare Test—a series of monochromatic square-wave gratings with three different spatial frequencies, while controlling for psychological variables related to sensory sensitivity with multiple questionnaires. Resting neurotransmitter concentrations in primary visual cortex (V1) and right anterior insula were studied in 160 healthy participants using magnetic resonance spectroscopy. Results: Data showed significant differences in the perception of visual distortions (VD) and comfort scores between men and women, with women generally reporting more VD, and therefore the modulatory effect of sex was considered in a further examination. A general linear model analysis showed a negative effect of occipital glutamate on a number of reported visual distortions, but also a significant role of several background psychological traits. When assessing comfort scores in women, an important intervening variable was the menstrual cycle. Discussion: Our findings do not support that baseline neurotransmitter levels have a significant role in overreactivity to aversive stimuli in neurotypical population. However, we demonstrated that biological sex can have a significant impact on subjective responses. Based on this additional finding, we suggest that future studies investigate aversive visual stimuli while examining the role of biological sex.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

MUNI/A/1465/2020, interní kód MU

Název: Vědomí a kognice u mozkových onemocnění

Investor: Masarykova univerzita, Vědomí a kognice u mozkových onemocnění

MUNI/A/1568/2023, interní kód MU

Název: Studium neurálních korelátů vědomí a kognice

Investor: Masarykova univerzita, Studium neurálních korelátů vědomí a kognice

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Přiložené soubory

Subjective_visual_sensitivity_in_neurotypical_adults_insights_from_a_magnetic_resonance_spectroscopy_study.pdf

Citovat

JURKOVIČOVÁ, Lenka; Julie PÁLENÍK; Petr KUDLIČKA; Lenka SAKÁLOŠOVÁ; Alexandra RUŽIČKOVÁ; Vojtěch JUŘÍK; Radek MAREČEK; Robert ROMAN; Jason J. BRAITHWAITE; Kristian SANDBERG; Jamie NEAR a Milan BRÁZDIL. Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study. FRONTIERS IN NEUROSCIENCE. SWITZERLAND: FRONTIERS MEDIA SA, 2024, roč. 18, September 2024, s. 1-16. ISSN 1662-453X. Dostupné z: https://doi.org/10.3389/fnins.2024.1417996.

@article{2439257,
   author = {Jurkovičová, Lenka and Páleník, Julie and Kudlička, Petr and Sakálošová, Lenka and Ružičková, Alexandra and Juřík, Vojtěch and Mareček, Radek and Roman, Robert and Braithwaite, Jason J. and Sandberg, Kristian and Near, Jamie and Brázdil, Milan},
   article_location = {SWITZERLAND},
   article_number = {September 2024},
   doi = {https://doi.org/10.3389/fnins.2024.1417996},
   keywords = {Pattern Glare Test; visual discomfort; magnetic resonance spectroscopy; GABA; glutamate; cortical excitability},
   language = {eng},
   issn = {1662-453X},
   journal = {FRONTIERS IN NEUROSCIENCE},
   title = {Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study},
   url = {https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1417996/full},
   volume = {18},
   year = {2024}
}

TY  - JOUR
ID  - 2439257
AU  - Jurkovičová, Lenka - Páleník, Julie - Kudlička, Petr - Sakálošová, Lenka - Ružičková, Alexandra - Juřík, Vojtěch - Mareček, Radek - Roman, Robert - Braithwaite, Jason J. - Sandberg, Kristian - Near, Jamie - Brázdil, Milan
PY  - 2024
TI  - Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study
JF  - FRONTIERS IN NEUROSCIENCE
VL  - 18
IS  - September 2024
SP  - 1-16
EP  - 1-16
PB  - FRONTIERS MEDIA SA
SN  - 1662453X
KW  - Pattern Glare Test
KW  - visual discomfort
KW  - magnetic resonance spectroscopy
KW  - GABA
KW  - glutamate
KW  - cortical excitability
UR  - https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1417996/full
N2  - Introduction: Altered subjective visual sensitivity manifests as feelings of discomfort or overload elicited by intense and irritative visual stimuli. This can result in a host of visual aberrations including visual distortions, elementary visual hallucinations and visceral responses like dizziness and nausea, collectively referred to as “pattern glare.” Current knowledge of the underlying neural mechanisms has focused on overall excitability of the visual cortex, but the individual contribution of excitatory and inhibitory systems has not yet been quantified. Methods: In this study, we focus on the role of glutamate and γ-aminobutyric acid (GABA) as potential mediators of individual differences in subjective visual sensitivity, measured by a computerized Pattern Glare Test—a series of monochromatic square-wave gratings with three different spatial frequencies, while controlling for psychological variables related to sensory sensitivity with multiple questionnaires. Resting neurotransmitter concentrations in primary visual cortex (V1) and right anterior insula were studied in 160 healthy participants using magnetic resonance spectroscopy. Results: Data showed significant differences in the perception of visual distortions (VD) and comfort scores between men and women, with women generally reporting more VD, and therefore the modulatory effect of sex was considered in a further examination. A general linear model analysis showed a negative effect of occipital glutamate on a number of reported visual distortions, but also a significant role of several background psychological traits. When assessing comfort scores in women, an important intervening variable was the menstrual cycle. Discussion: Our findings do not support that baseline neurotransmitter levels have a significant role in overreactivity to aversive stimuli in neurotypical population. However, we demonstrated that biological sex can have a significant impact on subjective responses. Based on this additional finding, we suggest that future studies investigate aversive visual stimuli while examining the role of biological sex.
ER  -

JURKOVIČOVÁ, Lenka; Julie PÁLENÍK; Petr KUDLIČKA; Lenka SAKÁLOŠOVÁ; Alexandra RUŽIČKOVÁ; Vojtěch JUŘÍK; Radek MAREČEK; Robert ROMAN; Jason J. BRAITHWAITE; Kristian SANDBERG; Jamie NEAR a Milan BRÁZDIL. Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study. \textit{FRONTIERS IN NEUROSCIENCE}. SWITZERLAND: FRONTIERS MEDIA SA, 2024, roč.~18, September 2024, s.~1-16. ISSN~1662-453X. Dostupné z: https://doi.org/10.3389/fnins.2024.1417996.

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