Association between FTO polymorphism and COVID-19 mortality
among older adults: A population-based cohort study

J 2024

Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study

HUBACEK, Jaroslav A.; Naděžda ČAPKOVÁ; Martin BOBÁK a Hynek PIKHART

Základní údaje

Originální název

Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study

Autoři

HUBACEK, Jaroslav A.; Naděžda ČAPKOVÁ; Martin BOBÁK a Hynek PIKHART

Vydání

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, ENGLAND, ELSEVIER SCI LTD, 2024, 1201-9712

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300

Kód RIV

RIV/00216224:14310/24:00137283

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.ijid.2024.107232

UT WoS

001321339500001

EID Scopus

2-s2.0-85204425539

Klíčová slova anglicky

COVID-19; SARS-CoV-2FTO; Mortality; Polymorphism

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 7. 2025 12:09, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m6A RNA demethylase) and its functional rs17817449 polymorphism are candidates to influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 394 from other causes during the pandemic period. The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) than among survivors (19%) or deaths from other causes (20%), P <0.005. After multiple adjustments, GG homozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P <0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes. Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

857487, interní kód MU

Název: R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research (Akronym: R-Exposome Chair)

Investor: Evropská unie, R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research, Spreading excellence and widening participation

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90269, velká výzkumná infrastruktura

Název: RECETOX RI II

Přiložené soubory

2440239.pdf

Citovat

HUBACEK, Jaroslav A.; Naděžda ČAPKOVÁ; Martin BOBÁK a Hynek PIKHART. Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. ENGLAND: ELSEVIER SCI LTD, 2024, roč. 148, November 2024, s. 1-5. ISSN 1201-9712. Dostupné z: https://doi.org/10.1016/j.ijid.2024.107232.

@article{2440239,
   author = {Hubacek, Jaroslav A. and Čapková, Naděžda and Bobák, Martin and Pikhart, Hynek},
   article_location = {ENGLAND},
   article_number = {November 2024},
   doi = {https://doi.org/10.1016/j.ijid.2024.107232},
   keywords = {COVID-19; SARS-CoV-2FTO; Mortality; Polymorphism},
   language = {eng},
   issn = {1201-9712},
   journal = {INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES},
   note = {Nedoplňovat EF17_043/0009632.},
   title = {Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study},
   url = {https://www.sciencedirect.com/science/article/pii/S1201971224003035?via%3Dihub},
   volume = {148},
   year = {2024}
}

TY  - JOUR
ID  - 2440239
AU  - Hubacek, Jaroslav A. - Čapková, Naděžda - Bobák, Martin - Pikhart, Hynek
PY  - 2024
TI  - Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study
JF  - INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
VL  - 148
IS  - November 2024
SP  - 1-5
EP  - 1-5
PB  - ELSEVIER SCI LTD
SN  - 12019712
N1  - Nedoplňovat EF17_043/0009632.
KW  - COVID-19
KW  - SARS-CoV-2FTO
KW  - Mortality
KW  - Polymorphism
UR  - https://www.sciencedirect.com/science/article/pii/S1201971224003035?via%3Dihub
N2  - COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m6A RNA demethylase) and its functional rs17817449 polymorphism are candidates to influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where 70 persons died from COVID-19 and 394 from other causes during the pandemic period. The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) than among survivors (19%) or deaths from other causes (20%), P <0.005. After multiple adjustments, GG homozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P <0.01) compared with carriers of at least one T allele. The FTO polymorphism was not associated with mortality from other causes. Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.
ER  -

HUBACEK, Jaroslav A.; Naděžda ČAPKOVÁ; Martin BOBÁK a Hynek PIKHART. Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study. \textit{INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES}. ENGLAND: ELSEVIER SCI LTD, 2024, roč.~148, November 2024, s.~1-5. ISSN~1201-9712. Dostupné z: https://doi.org/10.1016/j.ijid.2024.107232.

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