Short- and long-term clinical outcomes of nintedanib therapy in IPF patients with different phenotypes: A retrospective registry-based study

KOZIAR VASAKOVA, Martina, Jakub GREGOR, Nesrin MOGULKOC, Mordechai R KRAMER, Katarzyna LEWANDOWSKA, Martina STERCLOVA, Veronika MUELLER, Robert SLIVKA, Michael STUDNICKA, Martina PLACKOVA, Monika ZURKOVA, Jasna TEKAVEC-TRKANJEC, Martina DOUBKOVÁ a Petra OVESNÁ. Short- and long-term clinical outcomes of nintedanib therapy in IPF patients with different phenotypes: A retrospective registry-based study. RESPIRATORY MEDICINE. LONDON: W B SAUNDERS CO LTD, 2024, roč. 234, November-December 2024, s. 1-8. ISSN 0954-6111. Dostupné z: https://dx.doi.org/10.1016/j.rmed.2024.107791.

Základní údaje

• Originální název: Short- and long-term clinical outcomes of nintedanib therapy in IPF patients with different phenotypes: A retrospective registry-based study
• Autoři: KOZIAR VASAKOVA, Martina (203 Česká republika), Jakub GREGOR (203 Česká republika, domácí), Nesrin MOGULKOC, Mordechai R KRAMER, Katarzyna LEWANDOWSKA, Martina STERCLOVA (203 Česká republika), Veronika MUELLER, Robert SLIVKA, Michael STUDNICKA (203 Česká republika), Martina PLACKOVA (203 Česká republika), Monika ZURKOVA (203 Česká republika), Jasna TEKAVEC-TRKANJEC, Martina DOUBKOVÁ (203 Česká republika, domácí) a Petra OVESNÁ (203 Česká republika, domácí).
• Vydání: RESPIRATORY MEDICINE, LONDON, W B SAUNDERS CO LTD, 2024, 0954-6111.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30203 Respiratory systems
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 4.300 v roce 2022
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1016/j.rmed.2024.107791
• UT WoS: 001318539800001
• Klíčová slova anglicky: Idiopathic pulmonary fibrosis; Treatment; Survival; Lung
• Štítky: 14110215, 14119612, rivok
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Background: There is a lack of data on the long-term effect of nintedanib on survival in specific groups of idiopathic pulmonary fibrosis (IPF) patients with different phenotypes. We investigated the outcomes of nintedanib therapy in an observational study of a large multicentre real-world cohort of IPF patients with various initial characteristics. Methods: The analysis included IPF patients treated with nintedanib (NIN) and IPF patients not receiving anti- fibrotic treatment (NAF) enrolled for the EMPIRE registry in 2015-2020. The patients were stratified according to their initial FVC predicted, dyspnoea, UIP pattern and age. All-cause mortality and annual rate of FVC decline were the main endpoints. Cox proportional hazards model for survival assessment and linear mixed-effects model for FVC decline modelling were used. Results: A total of 869 NIN patients and 691 NAF patients were eligible for the analysis. The annual FVC decline rate was significantly different (adjusted values-0.053 l/yr vs-0.122 l/yr; p = 0.001). The adjusted hazard ratio (HR) for mortality was 0.40 (95 % CI 0.3 to 0.53, p < 0.001). The most significant effect of nintedanib was demonstrated in patients with impaired lung function, i.e., with an FVC predicted to be less than 80 % and a NYHA II to IV. Nintedanib therapy also reduced the difference in survival between men and women. Conclusions: Modelling confirmed that NIN therapy reduced differences in OS between patients with better and worse initial conditions and prognosis. Our results indicate that NIN is particularly beneficial for patients with advanced IPF and more severe phenotypes. Trial registration: EMPIRE was registered as a non-interventional post-registration study at the State Institute for Drug Control of the Czech Republic under ID 1412080000 on December 8, 2014.