Optimal hematocrit theory: a review

J 2024

Optimal hematocrit theory: a review

ŠITINA, Michal, Heiko STARK a Stefan SCHUSTER

Základní údaje

Originální název

Optimal hematocrit theory: a review

Autoři

ŠITINA, Michal (203 Česká republika, domácí), Heiko STARK a Stefan SCHUSTER

Vydání

JOURNAL OF APPLIED PHYSIOLOGY, Rockville, AMER PHYSIOLOGICAL SOC, 2024, 8750-7587

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.300 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1152/japplphysiol.00034.2024

UT WoS

001313861700001

Klíčová slova anglicky

blood doping; blood viscosity; hematocrit on exertion; high-altitude adaptation; optimal hematocrit theory

Štítky

14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 10. 2024 14:53, Mgr. Tereza Miškechová

Anotace

V originále

In humans and many animals, a trade-off between a sufficiently high concentration of erythrocytes (hematocrit) to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. The optimal value lies between the extreme cases of pure blood plasma, which cannot practically transport any oxygen, and 100% hematocrit, which would imply very slow blood flow or none at all. As oxygen delivery to tissues is the main task of the cardiovascular system, it is reasonable to expect that maximum oxygen delivery has been achieved during evolution. Optimal hematocrit theory, based on this optimality principle, has been successful in predicting hematocrit values of about 0.3-0.5, which are indeed observed in the systemic circulation of humans and many animal species. Similarly, the theory can explain why a hematocrit higher than normal, ranging from 0.5 to 0.7, can promote better exertional performance. Here, we present a review of theoretical approaches to the calculation of the optimal hematocrit value under different conditions and discuss them in a broad physiological context. Several physiological and medical implications are outlined, for example, in view of blood doping, temperature adaptation, dehydration, and life at high altitudes.

Citovat

ŠITINA, Michal, Heiko STARK a Stefan SCHUSTER. Optimal hematocrit theory: a review. JOURNAL OF APPLIED PHYSIOLOGY. Rockville: AMER PHYSIOLOGICAL SOC, 2024, roč. 137, č. 3, s. 494-509. ISSN 8750-7587. Dostupné z: https://dx.doi.org/10.1152/japplphysiol.00034.2024.

@article{2447849,
   author = {Šitina, Michal and Stark, Heiko and Schuster, Stefan},
   article_location = {Rockville},
   article_number = {3},
   doi = {http://dx.doi.org/10.1152/japplphysiol.00034.2024},
   keywords = {blood doping; blood viscosity; hematocrit on exertion; high-altitude adaptation; optimal hematocrit theory},
   language = {eng},
   issn = {8750-7587},
   journal = {JOURNAL OF APPLIED PHYSIOLOGY},
   title = {Optimal hematocrit theory: a review},
   url = {https://journals.physiology.org/doi/full/10.1152/japplphysiol.00034.2024},
   volume = {137},
   year = {2024}
}

TY  - JOUR
ID  - 2447849
AU  - Šitina, Michal - Stark, Heiko - Schuster, Stefan
PY  - 2024
TI  - Optimal hematocrit theory: a review
JF  - JOURNAL OF APPLIED PHYSIOLOGY
VL  - 137
IS  - 3
SP  - 494-509
EP  - 494-509
PB  - AMER PHYSIOLOGICAL SOC
SN  - 87507587
KW  - blood doping
KW  - blood viscosity
KW  - hematocrit on exertion
KW  - high-altitude adaptation
KW  - optimal hematocrit theory
UR  - https://journals.physiology.org/doi/full/10.1152/japplphysiol.00034.2024
N2  - In humans and many animals, a trade-off between a sufficiently high concentration of erythrocytes (hematocrit) to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. The optimal value lies between the extreme cases of pure blood plasma, which cannot practically transport any oxygen, and 100% hematocrit, which would imply very slow blood flow or none at all. As oxygen delivery to tissues is the main task of the cardiovascular system, it is reasonable to expect that maximum oxygen delivery has been achieved during evolution. Optimal hematocrit theory, based on this optimality principle, has been successful in predicting hematocrit values of about 0.3-0.5, which are indeed observed in the systemic circulation of humans and many animal species. Similarly, the theory can explain why a hematocrit higher than normal, ranging from 0.5 to 0.7, can promote better exertional performance. Here, we present a review of theoretical approaches to the calculation of the optimal hematocrit value under different conditions and discuss them in a broad physiological context. Several physiological and medical implications are outlined, for example, in view of blood doping, temperature adaptation, dehydration, and life at high altitudes.
ER  -

ŠITINA, Michal, Heiko STARK a Stefan SCHUSTER. Optimal hematocrit theory: a review. \textit{JOURNAL OF APPLIED PHYSIOLOGY}. Rockville: AMER PHYSIOLOGICAL SOC, 2024, roč.~137, č.~3, s.~494-509. ISSN~8750-7587. Dostupné z: https://dx.doi.org/10.1152/japplphysiol.00034.2024.

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