The relationship between gadolinium enhancement and [18
F]fluorothymidine uptake in brain lesions with the use of
hybrid PET/MRI

J 2024

The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI

ROHAN, Tomáš, Petr HLOŽANKA, Marek DOSTÁL, Tereza KOPŘIVOVÁ, Tomáš MACEK et. al.

Základní údaje

Originální název

The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI

Autoři

ROHAN, Tomáš (203 Česká republika, domácí), Petr HLOŽANKA (203 Česká republika), Marek DOSTÁL (203 Česká republika, domácí), Tereza KOPŘIVOVÁ (203 Česká republika, domácí), Tomáš MACEK (203 Česká republika, domácí), Václav VYBÍHAL (203 Česká republika, domácí), Hiroko Jeannette MARTIN (840 Spojené státy), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Česká republika, domácí) a Miloš KEŘKOVSKÝ (203 Česká republika, domácí)

Vydání

CANCER IMAGING, LONDON, BMC, 2024, 1740-5025

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.500 v roce 2023

Kód RIV

RIV/00216224:14110/24:00138513

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s40644-024-00761-0

UT WoS

001294131700001

EID Scopus

2-s2.0-85201539804

Klíčová slova anglicky

PET/MRI; [F-18]FLT; Brain tumour; Tumour-like lesions; High grade; Low grade

Štítky

14110216, 14110224, 14110511, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 1. 2025 10:46, Mgr. Tereza Miškechová

Anotace

V originále

Background To evaluate and compare the diagnostic power of [F-18]FLT-PET with ceMRI in patients with brain tumours or other focal lesions. Methods 121 patients with suspected brain tumour or those after brain tumour surgery were enroled in this retrospective study (61 females, 60 males, mean age 37.3 years, range 1-80 years). All patients underwent [F-18]FLT-PET/MRI with gadolinium contrast agent application. In 118 of these patients, a final diagnosis was made, verified by histopathology or by follow-up. Agreement between ceMRI and [F-18]FLT-PET of the whole study group was established. Further, sensitivity and specificity of ceMRI and [F-18]FLT-PET were calculated for differentiation of high-grade vs. low-grade tumours, high-grade vs. low-grade tumours together with non-tumour lesions and for differentiation of high-grade tumours from all other verified lesions. Results [F-18]FLT-PET and ceMRI findings were concordant in 119 cases (98%). On closer analysis of a subset of 64 patients with verified gliomas, the sensitivity and specificity of both PET and ceMRI were identical (90% and 84%, respectively) for differentiating low-grade from high-grade tumours, if the contrast enhancement and [F-18]FLT uptake were considered as hallmarks of high-grade tumour. For differentiation of high-grade tumours from low-grade tumours and lesions of nontumorous aetiology (e.g., inflammatory lesions or post-therapeutic changes) in a subgroup of 93 patients by visual evaluation, the sensitivity of both PET and ceMRI was 90%, whereas the specificity of PET was slightly higher (61%) compared to ceMRI (57%). By receiver operating characteristic analysis, the sensitivity and specificity were 82% and 74%, respectively, when the threshold of SUVmax in the tumour was set to 0.9 g/ml. Conclusion We demonstrated a generally very high correlation of [F-18]FLT accumulation with contrast enhancement visible on ceMRI and a comparable diagnostic yield in both modalities for differentiating high-grade tumours from low-grade tumours and lesions of other aetiology.

Návaznosti

MUNI/A/1611/2023, interní kód MU

Název: Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

Investor: Masarykova univerzita, Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

Citovat

ROHAN, Tomáš, Petr HLOŽANKA, Marek DOSTÁL, Tereza KOPŘIVOVÁ, Tomáš MACEK, Václav VYBÍHAL, Hiroko Jeannette MARTIN, Andrea ŠPRLÁKOVÁ-PUKOVÁ a Miloš KEŘKOVSKÝ. The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI. CANCER IMAGING. LONDON: BMC, 2024, roč. 24, č. 1, s. 1-9. ISSN 1740-5025. Dostupné z: https://dx.doi.org/10.1186/s40644-024-00761-0.

@article{2468654,
   author = {Rohan, Tomáš and Hložanka, Petr and Dostál, Marek and Kopřivová, Tereza and Macek, Tomáš and Vybíhal, Václav and Martin, Hiroko Jeannette and ŠprlákováandPuková, Andrea and Keřkovský, Miloš},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s40644-024-00761-0},
   keywords = {PET/MRI; [F-18]FLT; Brain tumour; Tumour-like lesions; High grade; Low grade},
   language = {eng},
   issn = {1740-5025},
   journal = {CANCER IMAGING},
   title = {The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI},
   url = {https://cancerimagingjournal.biomedcentral.com/articles/10.1186/s40644-024-00761-0},
   volume = {24},
   year = {2024}
}

TY  - JOUR
ID  - 2468654
AU  - Rohan, Tomáš - Hložanka, Petr - Dostál, Marek - Kopřivová, Tereza - Macek, Tomáš - Vybíhal, Václav - Martin, Hiroko Jeannette - Šprláková-Puková, Andrea - Keřkovský, Miloš
PY  - 2024
TI  - The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI
JF  - CANCER IMAGING
VL  - 24
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - BMC
SN  - 17405025
KW  - PET/MRI
KW  - [F-18]FLT
KW  - Brain tumour
KW  - Tumour-like lesions
KW  - High grade
KW  - Low grade
UR  - https://cancerimagingjournal.biomedcentral.com/articles/10.1186/s40644-024-00761-0
N2  - Background To evaluate and compare the diagnostic power of [F-18]FLT-PET with ceMRI in patients with brain tumours or other focal lesions. Methods 121 patients with suspected brain tumour or those after brain tumour surgery were enroled in this retrospective study (61 females, 60 males, mean age 37.3 years, range 1-80 years). All patients underwent [F-18]FLT-PET/MRI with gadolinium contrast agent application. In 118 of these patients, a final diagnosis was made, verified by histopathology or by follow-up. Agreement between ceMRI and [F-18]FLT-PET of the whole study group was established. Further, sensitivity and specificity of ceMRI and [F-18]FLT-PET were calculated for differentiation of high-grade vs. low-grade tumours, high-grade vs. low-grade tumours together with non-tumour lesions and for differentiation of high-grade tumours from all other verified lesions. Results [F-18]FLT-PET and ceMRI findings were concordant in 119 cases (98%). On closer analysis of a subset of 64 patients with verified gliomas, the sensitivity and specificity of both PET and ceMRI were identical (90% and 84%, respectively) for differentiating low-grade from high-grade tumours, if the contrast enhancement and [F-18]FLT uptake were considered as hallmarks of high-grade tumour. For differentiation of high-grade tumours from low-grade tumours and lesions of nontumorous aetiology (e.g., inflammatory lesions or post-therapeutic changes) in a subgroup of 93 patients by visual evaluation, the sensitivity of both PET and ceMRI was 90%, whereas the specificity of PET was slightly higher (61%) compared to ceMRI (57%). By receiver operating characteristic analysis, the sensitivity and specificity were 82% and 74%, respectively, when the threshold of SUVmax in the tumour was set to 0.9 g/ml. Conclusion We demonstrated a generally very high correlation of [F-18]FLT accumulation with contrast enhancement visible on ceMRI and a comparable diagnostic yield in both modalities for differentiating high-grade tumours from low-grade tumours and lesions of other aetiology.
ER  -

ROHAN, Tomáš, Petr HLOŽANKA, Marek DOSTÁL, Tereza KOPŘIVOVÁ, Tomáš MACEK, Václav VYBÍHAL, Hiroko Jeannette MARTIN, Andrea ŠPRLÁKOVÁ-PUKOVÁ a Miloš KEŘKOVSKÝ. The relationship between gadolinium enhancement and [18 F]fluorothymidine uptake in brain lesions with the use of hybrid PET/MRI. \textit{CANCER IMAGING}. LONDON: BMC, 2024, roč.~24, č.~1, s.~1-9. ISSN~1740-5025. Dostupné z: https://dx.doi.org/10.1186/s40644-024-00761-0.

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