Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions

J 2025

Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions

KUNOVSKÝ, Lumír, Eliška TVRDÍKOVÁ, Jozef MICHALKA a Jan TRNA

Základní údaje

Originální název

Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions

Autoři

KUNOVSKÝ, Lumír, Eliška TVRDÍKOVÁ, Jozef MICHALKA a Jan TRNA

Vydání

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, CHICHESTER, JOHN WILEY & SONS LTD, 2025, 2050-6406

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.800 v roce 2023

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/ueg2.12752

UT WoS

001396669400001

Klíčová slova anglicky

biopsy; chemotherapy; colorectal cancer; endoscopy; lymphoma; multiple lymphomatous polyposis

Štítky

14110212, 14110223, 14110811

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 2. 2025 11:00, Mgr. Tereza Miškechová

Anotace

V originále

A 67-year-old man was referred for colonoscopy following a positive fecal occult blood test and the detection of thrombocytopenia. Clinically, the patient was asymptomatic. He was under oncological follow-up after previous surgical treatment for testicular cancer. During the colonoscopy, a laterally spreading tumor (LST) non-granular lesion measuring 25 × 20 mm was found in the upper rectum, classified as Paris IIa + IIc (Figure 1). The lesion was carefully evaluated using narrow band imaging (NBI) (Figure 2a) and magnifying endoscopy (Figure 2b). However, due to the unclear polyp surface and signs of pseudo-depression, biopsies were taken from the lesion. An additional five smaller lesions, each measuring 4–5 mm (Is), were found in the mid-rectum (Figure 3). All small polyps in the mid-rectum were resected using cold snare polypectomy. Histopathological examination (Figure 4a,b: HE staining, Figure 5a–d: Immunohistochemistry staining) confirmed the diagnosis of Mantle Cell Lymphoma (MCL) from both the main lesion and the smaller ones. Subsequently, the patient was referred to the Department of Hematology and Oncology, where standard staging procedures were completed. The disease was classified as stage IV A according to the Ann Arbor classification, with generalized lymphadenopathy identified on staging PET/CT imaging. Histological and flow cytometric analysis confirmed minor bone marrow infiltration. After six cycles of rituximab-based chemoimmunotherapy, the patient achieved complete remission of the lymphoma.

Citovat

KUNOVSKÝ, Lumír, Eliška TVRDÍKOVÁ, Jozef MICHALKA a Jan TRNA. Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions. UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. CHICHESTER: JOHN WILEY & SONS LTD, 2025, 3 s. ISSN 2050-6406. Dostupné z: https://dx.doi.org/10.1002/ueg2.12752.

@article{2471522,
   author = {Kunovský, Lumír and Tvrdíková, Eliška and Michalka, Jozef and Trna, Jan},
   article_location = {CHICHESTER},
   doi = {http://dx.doi.org/10.1002/ueg2.12752},
   keywords = {biopsy; chemotherapy; colorectal cancer; endoscopy; lymphoma; multiple lymphomatous polyposis},
   language = {eng},
   issn = {2050-6406},
   journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL},
   title = {Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12752},
   year = {2025}
}

TY  - JOUR
ID  - 2471522
AU  - Kunovský, Lumír - Tvrdíková, Eliška - Michalka, Jozef - Trna, Jan
PY  - 2025
TI  - Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions
JF  - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
PB  - JOHN WILEY & SONS LTD
SN  - 20506406
KW  - biopsy
KW  - chemotherapy
KW  - colorectal cancer
KW  - endoscopy
KW  - lymphoma
KW  - multiple lymphomatous polyposis
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12752
N2  - A 67-year-old man was referred for colonoscopy following a positive fecal occult blood test and the detection of thrombocytopenia. Clinically, the patient was asymptomatic. He was under oncological follow-up after previous surgical treatment for testicular cancer. During the colonoscopy, a laterally spreading tumor (LST) non-granular lesion measuring 25 × 20 mm was found in the upper rectum, classified as Paris IIa + IIc (Figure 1). The lesion was carefully evaluated using narrow band imaging (NBI) (Figure 2a) and magnifying endoscopy (Figure 2b). However, due to the unclear polyp surface and signs of pseudo-depression, biopsies were taken from the lesion. An additional five smaller lesions, each measuring 4–5 mm (Is), were found in the mid-rectum (Figure 3). All small polyps in the mid-rectum were resected using cold snare polypectomy. Histopathological examination (Figure 4a,b: HE staining, Figure 5a–d: Immunohistochemistry staining) confirmed the diagnosis of Mantle Cell Lymphoma (MCL) from both the main lesion and the smaller ones. Subsequently, the patient was referred to the Department of Hematology and Oncology, where standard staging procedures were completed. The disease was classified as stage IV A according to the Ann Arbor classification, with generalized lymphadenopathy identified on staging PET/CT imaging. Histological and flow cytometric analysis confirmed minor bone marrow infiltration. After six cycles of rituximab-based chemoimmunotherapy, the patient achieved complete remission of the lymphoma.
ER  -

KUNOVSKÝ, Lumír, Eliška TVRDÍKOVÁ, Jozef MICHALKA a Jan TRNA. Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions. \textit{UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}. CHICHESTER: JOHN WILEY \&{} SONS LTD, 2025, 3 s. ISSN~2050-6406. Dostupné z: https://dx.doi.org/10.1002/ueg2.12752.

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