Upper and/or Lower Respiratory Tract Infection Caused by Human
Metapneumovirus After Allogeneic Hematopoietic Stem Cell
Transplantation

J 2024

Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation

JOSE, Luis Pinana; Gloria TRIDELLO; Alienor XHAARD; Lotus WENDEL; Juan MONTORO et. al.

Basic information

Original name

Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation

Authors

JOSE, Luis Pinana; Gloria TRIDELLO; Alienor XHAARD; Lotus WENDEL; Juan MONTORO; Lourdes VAZQUEZ; Inmaculada HERAS; Per LJUNGMAN; Malgorzata MIKULSKA; Urpu SALMENNIEMI; Ariadna PEREZ; Nicolaus KROEGER; Jan CORNELISSEN; Elisa SALA; Rodrigo MARTINO; Claire GEURTEN; Jenny BYRNE; Johan MAERTENS; Tessa KERRE; Murray MARTIN; Jesus Pascual MARIA; Moshe YESHURUN; Juergen FINKE; Andreas H GROLL; Peter J SHAW; Nicole BLIJLEVENS; William ARCESE; Arnold GANSER; Maria SUAREZ-LLEDO; Mohsen ALZAHRANI; Goda CHOI; Edouard FORCADE; Annalisa PAVIGLIANITI; Carlos SOLANO; Jacek WACHOWIAK; Tsila ZUCKERMAN; Peter BADER; Johannes CLAUSEN; Jiří MAYER (203 Czech Republic, belonging to the institution); Wilfried SCHROYENS; Elisabetta METAFUNI; Nina KNELANGE; Dina AVERBUCH and de la Camara RAFAEL

Edition

JOURNAL OF INFECTIOUS DISEASES, CARY, OXFORD UNIV PRESS INC, 2024, 0022-1899

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30205 Hematology

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 5.000 in 2023

RIV identification code

RIV/00216224:14110/24:00138805

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/infdis/jiad268

UT WoS

001343885600005

EID Scopus

2-s2.0-85168092462

Keywords in English

SARS-CoV-2; allogeneic hematopoietic stem cell transplantation; community-acquired respiratory virus; human coronavirus; human metapneumovirus; immunocompromised; immunodeficiency score index; multiplex PCR assay

Abstract

V originále

Background Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area. Methods This retrospective multicenter cohort study examined the epidemiology, clinical characteristics, and risk factors for poor outcomes associated with human metapneumovirus (hMPV) infections in recipients of allo-HCT. Results We included 428 allo-HCT recipients who developed 438 hMPV infection episodes between January 2012 and January 2019. Most recipients were adults (93%). hMPV infections were diagnosed at a median of 373 days after allo-HCT. The infections were categorized as upper respiratory tract disease (URTD) or lower respiratory tract disease (LRTD), with 60% and 40% of cases, respectively. Patients with hMPV LRTD experienced the infection earlier in the transplant course and had higher rates of lymphopenia, neutropenia, corticosteroid use, and ribavirin therapy. Multivariate analysis identified lymphopenia and corticosteroid use (>30 mg/d) as independent risk factors for LRTD occurrence. The overall mortality at day 30 after hMPV detection was 2% for URTD, 12% for possible LRTD, and 21% for proven LRTD. Lymphopenia was the only independent risk factor associated with day 30 mortality in LRTD cases. Conclusions These findings highlight the significance of lymphopenia and corticosteroid use in the development and severity of hMPV infections after allo-HCT, with lymphopenia being a predictor of higher mortality in LRTD cases.

Cite

JOSE, Luis Pinana; Gloria TRIDELLO; Alienor XHAARD; Lotus WENDEL; Juan MONTORO; Lourdes VAZQUEZ; Inmaculada HERAS; Per LJUNGMAN; Malgorzata MIKULSKA; Urpu SALMENNIEMI; Ariadna PEREZ; Nicolaus KROEGER; Jan CORNELISSEN; Elisa SALA; Rodrigo MARTINO; Claire GEURTEN; Jenny BYRNE; Johan MAERTENS; Tessa KERRE; Murray MARTIN; Jesus Pascual MARIA; Moshe YESHURUN; Juergen FINKE; Andreas H GROLL; Peter J SHAW; Nicole BLIJLEVENS; William ARCESE; Arnold GANSER; Maria SUAREZ-LLEDO; Mohsen ALZAHRANI; Goda CHOI; Edouard FORCADE; Annalisa PAVIGLIANITI; Carlos SOLANO; Jacek WACHOWIAK; Tsila ZUCKERMAN; Peter BADER; Johannes CLAUSEN; Jiří MAYER; Wilfried SCHROYENS; Elisabetta METAFUNI; Nina KNELANGE; Dina AVERBUCH and de la Camara RAFAEL. Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation. JOURNAL OF INFECTIOUS DISEASES. CARY: OXFORD UNIV PRESS INC, 2024, vol. 229, No 1, p. 83-94. ISSN 0022-1899. Available from: https://dx.doi.org/10.1093/infdis/jiad268.

@article{2475088,
   author = {Jose, Luis Pinana and Tridello, Gloria and Xhaard, Alienor and Wendel, Lotus and Montoro, Juan and Vazquez, Lourdes and Heras, Inmaculada and Ljungman, Per and Mikulska, Malgorzata and Salmenniemi, Urpu and Perez, Ariadna and Kroeger, Nicolaus and Cornelissen, Jan and Sala, Elisa and Martino, Rodrigo and Geurten, Claire and Byrne, Jenny and Maertens, Johan and Kerre, Tessa and Martin, Murray and Maria, Jesus Pascual and Yeshurun, Moshe and Finke, Juergen and Groll, Andreas H and Shaw, Peter J and Blijlevens, Nicole and Arcese, William and Ganser, Arnold and SuarezandLledo, Maria and Alzahrani, Mohsen and Choi, Goda and Forcade, Edouard and Paviglianiti, Annalisa and Solano, Carlos and Wachowiak, Jacek and Zuckerman, Tsila and Bader, Peter and Clausen, Johannes and Mayer, Jiří and Schroyens, Wilfried and Metafuni, Elisabetta and Knelange, Nina and Averbuch, Dina and Rafael, de la Camara},
   article_location = {CARY},
   article_number = {1},
   doi = {http://dx.doi.org/10.1093/infdis/jiad268},
   keywords = {SARS-CoV-2; allogeneic hematopoietic stem cell transplantation; community-acquired respiratory virus; human coronavirus; human metapneumovirus; immunocompromised; immunodeficiency score index; multiplex PCR assay},
   language = {eng},
   issn = {0022-1899},
   journal = {JOURNAL OF INFECTIOUS DISEASES},
   title = {Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation},
   url = {https://academic.oup.com/jid/article/229/1/83/7223877?login=true},
   volume = {229},
   year = {2024}
}

TY  - JOUR
ID  - 2475088
AU  - Jose, Luis Pinana - Tridello, Gloria - Xhaard, Alienor - Wendel, Lotus - Montoro, Juan - Vazquez, Lourdes - Heras, Inmaculada - Ljungman, Per - Mikulska, Malgorzata - Salmenniemi, Urpu - Perez, Ariadna - Kroeger, Nicolaus - Cornelissen, Jan - Sala, Elisa - Martino, Rodrigo - Geurten, Claire - Byrne, Jenny - Maertens, Johan - Kerre, Tessa - Martin, Murray - Maria, Jesus Pascual - Yeshurun, Moshe - Finke, Juergen - Groll, Andreas H - Shaw, Peter J - Blijlevens, Nicole - Arcese, William - Ganser, Arnold - Suarez-Lledo, Maria - Alzahrani, Mohsen - Choi, Goda - Forcade, Edouard - Paviglianiti, Annalisa - Solano, Carlos - Wachowiak, Jacek - Zuckerman, Tsila - Bader, Peter - Clausen, Johannes - Mayer, Jiří - Schroyens, Wilfried - Metafuni, Elisabetta - Knelange, Nina - Averbuch, Dina - Rafael, de la Camara
PY  - 2024
TI  - Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation
JF  - JOURNAL OF INFECTIOUS DISEASES
VL  - 229
IS  - 1
SP  - 83-94
EP  - 83-94
PB  - OXFORD UNIV PRESS INC
SN  - 00221899
KW  - SARS-CoV-2
KW  - allogeneic hematopoietic stem cell transplantation
KW  - community-acquired respiratory virus
KW  - human coronavirus
KW  - human metapneumovirus
KW  - immunocompromised
KW  - immunodeficiency score index
KW  - multiplex PCR assay
UR  - https://academic.oup.com/jid/article/229/1/83/7223877?login=true
N2  - Background Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area. Methods This retrospective multicenter cohort study examined the epidemiology, clinical characteristics, and risk factors for poor outcomes associated with human metapneumovirus (hMPV) infections in recipients of allo-HCT. Results We included 428 allo-HCT recipients who developed 438 hMPV infection episodes between January 2012 and January 2019. Most recipients were adults (93%). hMPV infections were diagnosed at a median of 373 days after allo-HCT. The infections were categorized as upper respiratory tract disease (URTD) or lower respiratory tract disease (LRTD), with 60% and 40% of cases, respectively. Patients with hMPV LRTD experienced the infection earlier in the transplant course and had higher rates of lymphopenia, neutropenia, corticosteroid use, and ribavirin therapy. Multivariate analysis identified lymphopenia and corticosteroid use (>30 mg/d) as independent risk factors for LRTD occurrence. The overall mortality at day 30 after hMPV detection was 2% for URTD, 12% for possible LRTD, and 21% for proven LRTD. Lymphopenia was the only independent risk factor associated with day 30 mortality in LRTD cases. Conclusions These findings highlight the significance of lymphopenia and corticosteroid use in the development and severity of hMPV infections after allo-HCT, with lymphopenia being a predictor of higher mortality in LRTD cases.
ER  -

JOSE, Luis Pinana; Gloria TRIDELLO; Alienor XHAARD; Lotus WENDEL; Juan MONTORO; Lourdes VAZQUEZ; Inmaculada HERAS; Per LJUNGMAN; Malgorzata MIKULSKA; Urpu SALMENNIEMI; Ariadna PEREZ; Nicolaus KROEGER; Jan CORNELISSEN; Elisa SALA; Rodrigo MARTINO; Claire GEURTEN; Jenny BYRNE; Johan MAERTENS; Tessa KERRE; Murray MARTIN; Jesus Pascual MARIA; Moshe YESHURUN; Juergen FINKE; Andreas H GROLL; Peter J SHAW; Nicole BLIJLEVENS; William ARCESE; Arnold GANSER; Maria SUAREZ-LLEDO; Mohsen ALZAHRANI; Goda CHOI; Edouard FORCADE; Annalisa PAVIGLIANITI; Carlos SOLANO; Jacek WACHOWIAK; Tsila ZUCKERMAN; Peter BADER; Johannes CLAUSEN; Jiří MAYER; Wilfried SCHROYENS; Elisabetta METAFUNI; Nina KNELANGE; Dina AVERBUCH and de la Camara RAFAEL. Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation. \textit{JOURNAL OF INFECTIOUS DISEASES}. CARY: OXFORD UNIV PRESS INC, 2024, vol.~229, No~1, p.~83-94. ISSN~0022-1899. Available from: https://dx.doi.org/10.1093/infdis/jiad268.

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