Nutritional status and muscle mass loss in patients with COPD,
association with lung function, symptoms, comorbidities and
long-term survival: data from the National Database Study

J 2025

Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study

VOLAKOVA, Eva, Vladimir KOBLIZEK, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ et. al.

Basic information

Original name

Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study

Authors

VOLAKOVA, Eva, Vladimir KOBLIZEK, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Kristián BRAT, Martina KULIROVA and Jaromir ZATLOUKAL

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2025, 1213-8118

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30203 Respiratory systems

Country of publisher

Czech Republic

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 0.700 in 2023

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2025.001

UT WoS

001423967100001

Keywords in English

nutrition; muscle mass loss; body mass index; fat-free mass index; mid-arm muscle circumference; chronic obstructive pulmonary disease; COPD phenotype; comorbidities; survival

Abstract

V originále

Aim: To assess nutritional status and muscle mass loss in patients with chronic obstructice pulmonary disease (COPD) from the Czech National Database of COPD and to evaluate the association of nutritional parameters with COPD phenotype, lung function, COPD-related symptoms and long-term survival. Methods: A total of 343 patients with known body composition parameters - body mass Index (BMI), fat-free mass index (FFMI) and mid-art muscle circumference (MAMC) - were included in the analysis. Descriptive statistical methods were used to assess differences between groups, and overall survival was assessed using the Kaplan-Meier method after 9 years of follow-up. Results: Nutritional imbalances were common in patients with COPD. Underweight and muscle mass loss were associated with emphysematous and pulmonary cachexia phenotypes, worse lung function, more symptoms and exacerbations, osteoporosis and depression. Overweight and obesity were associated with a chronic bronchitis phenotype and cardiovascular and metabolic comorbidities. Obese patients had higher forced exspiratory volume in 1 second (FEV1) and diffusing capacity of the lung for carbon monoxid (DLCO), but lower forced exspiratory capacity (FVC). Malnutrition increased the risk of death. Cachexia and underweight reduced median survival from 72.0 to 43.5 (P=0.049) and 39.8 (P=0.010) months, respectively, compared to normal nutrition. Muscle mass loss by MAMC of ≥20% was the strongest predictor of mortality, increasing the risk of death by 5.5-fold compared to patients with normal muscle mass (P<0.001). Patients with overweight and obesity had a 40% (P=0.026) and 30% lower risk of death, respectively, compared to patients with normal nutrition. Conclusions: Patients with COPD often have nutritional imbalances. That is an important determinant of clinical characteristics and outcomes in patients with COPD. Further research is needed to better understand these differences.

Cite

VOLAKOVA, Eva, Vladimir KOBLIZEK, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Kristián BRAT, Martina KULIROVA and Jaromir ZATLOUKAL. Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2025, 16 pp. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2025.001.

@article{2489608,
   author = {Volakova, Eva and Koblizek, Vladimir and Svoboda, Michal and Hejduk, Karel and Plutinský, Marek and Brat, Kristián and Kulirova, Martina and Zatloukal, Jaromir},
   article_location = {Olomouc},
   doi = {http://dx.doi.org/10.5507/bp.2025.001},
   keywords = {nutrition; muscle mass loss; body mass index; fat-free mass index; mid-arm muscle circumference; chronic obstructive pulmonary disease; COPD phenotype; comorbidities; survival},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3873},
   year = {2025}
}

TY  - JOUR
ID  - 2489608
AU  - Volakova, Eva - Koblizek, Vladimir - Svoboda, Michal - Hejduk, Karel - Plutinský, Marek - Brat, Kristián - Kulirova, Martina - Zatloukal, Jaromir
PY  - 2025
TI  - Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study
JF  - Biomedical Papers, Olomouc: Palacky University
PB  - Palacky University
SN  - 12138118
KW  - nutrition
KW  - muscle mass loss
KW  - body mass index
KW  - fat-free mass index
KW  - mid-arm muscle circumference
KW  - chronic obstructive pulmonary disease
KW  - COPD phenotype
KW  - comorbidities
KW  - survival
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3873
N2  - Aim: To assess nutritional status and muscle mass loss in patients with chronic obstructice pulmonary disease (COPD) from the Czech National Database of COPD and to evaluate the association of nutritional parameters with COPD phenotype, lung function, COPD-related symptoms and long-term survival. Methods: A total of 343 patients with known body composition parameters - body mass Index (BMI), fat-free mass index (FFMI) and mid-art muscle circumference (MAMC) - were included in the analysis. Descriptive statistical methods were used to assess differences between groups, and overall survival was assessed using the Kaplan-Meier method after 9 years of follow-up. Results: Nutritional imbalances were common in patients with COPD. Underweight and muscle mass loss were associated with emphysematous and pulmonary cachexia phenotypes, worse lung function, more symptoms and exacerbations, osteoporosis and depression. Overweight and obesity were associated with a chronic bronchitis phenotype and cardiovascular and metabolic comorbidities. Obese patients had higher forced exspiratory volume in 1 second (FEV1) and diffusing capacity of the lung for carbon monoxid (DLCO), but lower forced exspiratory capacity (FVC). Malnutrition increased the risk of death. Cachexia and underweight reduced median survival from 72.0 to 43.5 (P=0.049) and 39.8 (P=0.010) months, respectively, compared to normal nutrition. Muscle mass loss by MAMC of ≥20% was the strongest predictor of mortality, increasing the risk of death by 5.5-fold compared to patients with normal muscle mass (P<0.001). Patients with overweight and obesity had a 40% (P=0.026) and 30% lower risk of death, respectively, compared to patients with normal nutrition. Conclusions: Patients with COPD often have nutritional imbalances. That is an important determinant of clinical characteristics and outcomes in patients with COPD. Further research is needed to better understand these differences.
ER  -

VOLAKOVA, Eva, Vladimir KOBLIZEK, Michal SVOBODA, Karel HEJDUK, Marek PLUTINSKÝ, Kristián BRAT, Martina KULIROVA and Jaromir ZATLOUKAL. Nutritional status and muscle mass loss in patients with COPD, association with lung function, symptoms, comorbidities and long-term survival: data from the National Database Study. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2025, 16 pp. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2025.001.

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