ICP-QMS for lead isotopic analysis: Method development and key
parameters

J 2025

ICP-QMS for lead isotopic analysis: Method development and key parameters

DOBEŠ, Jan; Markéta HOLÁ; Tomas FOJTIK; Ladislav STRNAD; Viktor KANICKÝ et. al.

Basic information

Original name

ICP-QMS for lead isotopic analysis: Method development and key parameters

Authors

DOBEŠ, Jan (203 Czech Republic, belonging to the institution); Markéta HOLÁ (203 Czech Republic, belonging to the institution); Tomas FOJTIK; Ladislav STRNAD and Viktor KANICKÝ (203 Czech Republic, belonging to the institution)

Edition

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2025, 0584-8547

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10406 Analytical chemistry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 3.800 in 2024

Organization unit

Faculty of Science

DOI

https://doi.org/10.1016/j.sab.2025.107277

UT WoS

001553114000001

EID Scopus

2-s2.0-105011393117

Keywords in English

Isotope ratio analysis; Lead isotopes; ICP-QMS; Optimization parameters

Abstract

In the original language

This technical note demonstrates the potential of inductively coupled plasma mass spectrometry with a quadrupole analyzer (ICP-QMS) for lead isotope ratio determination offering a step-by-step guide for laboratories aiming to achieve reliable precision without access to multi-collector instrumentation. Key instrumental parameters such as dwell time, number of replicates, sweeps per replicate, pump speed and nebulizer gas flow were systematically optimized. Special attention was given to the influence of detector mode selection (Auto vs. Analog) and its impact on low-abundance isotopes such as Pb-204. The optimized procedure yielded precision of 0.08-0.10 % RSD for Pb-206/Pb-207 and Pb-208/Pb-206 ratios and 0.10-0.12 % RSD for Pb-206/Pb-204 as a minimum, which is sufficient for selected applications. The optimized method was validated using NIST SRM 981 and archaeological metal samples previously analyzed by MC-ICP-MS. Results show good agreement in isotope ratios between ICP-QMS and MC-ICP-MS, with deviations expressed as delta values <0.3 % in most cases, for Pb-206/Pb-204 < 1.5 %. Although the method does not aim to replace MC-ICP-MS for high-precision work, it offers a robust and cost-effective alternative for applications requiring moderate precision, especially in laboratories without access to multi-collector instrumentation.

Cite

DOBEŠ, Jan; Markéta HOLÁ; Tomas FOJTIK; Ladislav STRNAD and Viktor KANICKÝ. ICP-QMS for lead isotopic analysis: Method development and key parameters. SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2025, vol. 232, OCT, p. 1-7. ISSN 0584-8547. Available from: https://doi.org/10.1016/j.sab.2025.107277.

@article{2516706,
   author = {Dobeš, Jan and Holá, Markéta and Fojtik, Tomas and Strnad, Ladislav and Kanický, Viktor},
   article_location = {OXFORD},
   article_number = {OCT},
   doi = {https://doi.org/10.1016/j.sab.2025.107277},
   keywords = {Isotope ratio analysis; Lead isotopes; ICP-QMS; Optimization parameters},
   language = {eng},
   issn = {0584-8547},
   journal = {SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY},
   title = {ICP-QMS for lead isotopic analysis: Method development and key parameters},
   url = {https://www.sciencedirect.com/science/article/pii/S0584854725001624?via%3Dihub},
   volume = {232},
   year = {2025}
}

TY  - JOUR
ID  - 2516706
AU  - Dobeš, Jan - Holá, Markéta - Fojtik, Tomas - Strnad, Ladislav - Kanický, Viktor
PY  - 2025
TI  - ICP-QMS for lead isotopic analysis: Method development and key parameters
JF  - SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
VL  - 232
IS  - OCT
SP  - 1-7
EP  - 1-7
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 05848547
KW  - Isotope ratio analysis
KW  - Lead isotopes
KW  - ICP-QMS
KW  - Optimization parameters
UR  - https://www.sciencedirect.com/science/article/pii/S0584854725001624?via%3Dihub
N2  - This technical note demonstrates the potential of inductively coupled plasma mass spectrometry with a quadrupole analyzer (ICP-QMS) for lead isotope ratio determination offering a step-by-step guide for laboratories aiming to achieve reliable precision without access to multi-collector instrumentation. Key instrumental parameters such as dwell time, number of replicates, sweeps per replicate, pump speed and nebulizer gas flow were systematically optimized. Special attention was given to the influence of detector mode selection (Auto vs. Analog) and its impact on low-abundance isotopes such as Pb-204. The optimized procedure yielded precision of 0.08-0.10 % RSD for Pb-206/Pb-207 and Pb-208/Pb-206 ratios and 0.10-0.12 % RSD for Pb-206/Pb-204 as a minimum, which is sufficient for selected applications. The optimized method was validated using NIST SRM 981 and archaeological metal samples previously analyzed by MC-ICP-MS. Results show good agreement in isotope ratios between ICP-QMS and MC-ICP-MS, with deviations expressed as delta values <0.3 % in most cases, for Pb-206/Pb-204 < 1.5 %. Although the method does not aim to replace MC-ICP-MS for high-precision work, it offers a robust and cost-effective alternative for applications requiring moderate precision, especially in laboratories without access to multi-collector instrumentation.
ER  -

DOBEŠ, Jan; Markéta HOLÁ; Tomas FOJTIK; Ladislav STRNAD and Viktor KANICKÝ. ICP-QMS for lead isotopic analysis: Method development and key parameters. \textit{SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2025, vol.~232, OCT, p.~1-7. ISSN~0584-8547. Available from: https://doi.org/10.1016/j.sab.2025.107277.

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