Changing pattern of exposure to polycyclic aromatic
hydrocarbons over time in the Central European population

J 2026

Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population

SMETANOVÁ, Soňa; Akrem JBEBLI; Jiří KOHOUTEK; Vladimira PUKLOVA; Milena CERNA et al.

Základní údaje

Originální název

Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population

Autoři

Vydání

Journal of Exposure Science and Environmental Epidemiology, SPRINGER NATURE, 2026, 1559-0631

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.700 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Polycyclic aromatic hydrocarbons; Legislation; Chemical exposure; Biomonitoring

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 2. 2026 14:24, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

BackgroundTemporal trends of chemicals in the population are key to identifying changing sources of chemicals and determining the effectiveness of various legislative measures.ObjectiveThe present study focused on time comparisons to explore a possible decrease in PAH metabolite levels in the Czech population. Legislative measures occurred between sampling periods, including restricting smoking and the Air Protection Act.MethodsTen metabolites of PAHs were measured in urine samples collected in 2011-2012 from mothers and children from DEMOCOPHES-CZ study (N = 235) and in 2019-2020 from children, teenagers, and young adults from CELSPAC studies (N = 809). Multivariate linear regression, Kruskal-Wallis ANOVA, and Mann-Whitney test (MW) were used to investigate differences in OH-PAHs between periods, age categories, and exposure determinants.ResultsMedian concentrations significantly decreased between 2011-2020 by 30-35% for 1-OH-NAP, 2-and 3-OH-FLUO, 85% for 1-OH-PHE, and 44% for 2/3-OH-PHE, while 2-OH-NAP increased by 29% in non-smoking adults. In children, median concentrations of all metabolites decreased by 10-51%, with 2-OH-NAP rising by 49%. Smokers showed the largest differences, with significant decreases of 46-59% in the median concentrations of 2-OH-NAP, 2/3-OH-PHE, 9-OH-PHE, and 1-OH-PYR, and 76-91% in OH-FLUOs, 1-OH-NAP, and 1-OH-PHE. Fish and offal consumption, season, locality, and type of cooking were significant factors associated with levels of OH-PAHs, explaining 4-9% of the variability. Smoking was the main contributor in 2011, explaining up to 45% variability; no difference was found between smokers and non-smokers in 2019. New reference values of OH-PAHs in urine were calculated for the Czech population.ImpactThis study analyses the temporal trends of OH-PAHs in the population in the context of introduced legislative measures. In addition, it examines OH-PAH exposure in children, adolescents, and young adults in relation to lifestyle factors and establishes new reference values for polycyclic aromatic hydrocarbons that are important for public health decision-making. Biomonitoring over time is an essential tool for establishing new measures to protect public health.Created in BioRender. Komprdova, K. (2025) https://BioRender.com/u10q831.ImpactThis study analyses the temporal trends of OH-PAHs in the population in the context of introduced legislative measures. In addition, it examines OH-PAH exposure in children, adolescents, and young adults in relation to lifestyle factors and establishes new reference values for polycyclic aromatic hydrocarbons that are important for public health decision-making. Biomonitoring over time is an essential tool for establishing new measures to protect public health.Created in BioRender. Komprdova, K. (2025) https://BioRender.com/u10q831.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

733032, interní kód MU

Název: European Human Biomonitoring Initiative (Akronym: HBM4EU)

Investor: Evropská unie, European Human Biomonitoring Initiative, Health, demographic change and wellbeing (Societal Challenges)

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90269, velká výzkumná infrastruktura

Název: RECETOX RI II

Přiložené soubory

2519168.pdf

2519168_updated_version.pdf

Citovat

SMETANOVÁ, Soňa; Akrem JBEBLI; Jiří KOHOUTEK; Vladimira PUKLOVA; Milena CERNA; Andrea KRSKOVA; Martin ZVONAŘ; Zdenko REGULI; Lenka ANDRÝSKOVÁ; Pavel PILER; Petra PŘIBYLOVÁ; Jana KLÁNOVÁ; Elliott James PRICE a Klára KOMPRDOVÁ. Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population. Journal of Exposure Science and Environmental Epidemiology. SPRINGER NATURE, 2026, roč. 36, č. 1, s. 184-198. ISSN 1559-0631. Dostupné z: https://doi.org/10.1038/s41370-025-00793-z.

@article{2519168,
   author = {Smetanová, Soňa and Jbebli, Akrem and Kohoutek, Jiří and Puklova, Vladimira and Cerna, Milena and Krskova, Andrea and Zvonař, Martin and Reguli, Zdenko and Andrýsková, Lenka and Piler, Pavel and Přibylová, Petra and Klánová, Jana and Price, Elliott James and Komprdová, Klára},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41370-025-00793-z},
   keywords = {Polycyclic aromatic hydrocarbons; Legislation; Chemical exposure; Biomonitoring},
   language = {eng},
   issn = {1559-0631},
   journal = {Journal of Exposure Science and Environmental Epidemiology},
   title = {Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population},
   url = {https://www.nature.com/articles/s41370-025-00793-z},
   volume = {36},
   year = {2026}
}

TY  - JOUR
ID  - 2519168
AU  - Smetanová, Soňa - Jbebli, Akrem - Kohoutek, Jiří - Puklova, Vladimira - Cerna, Milena - Krskova, Andrea - Zvonař, Martin - Reguli, Zdenko - Andrýsková, Lenka - Piler, Pavel - Přibylová, Petra - Klánová, Jana - Price, Elliott James - Komprdová, Klára
PY  - 2026
TI  - Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population
JF  - Journal of Exposure Science and Environmental Epidemiology
VL  - 36
IS  - 1
SP  - 184-198
EP  - 184-198
PB  - SPRINGER NATURE
SN  - 15590631
KW  - Polycyclic aromatic hydrocarbons
KW  - Legislation
KW  - Chemical exposure
KW  - Biomonitoring
UR  - https://www.nature.com/articles/s41370-025-00793-z
N2  - BackgroundTemporal trends of chemicals in the population are key to identifying changing sources of chemicals and determining the effectiveness of various legislative measures.ObjectiveThe present study focused on time comparisons to explore a possible decrease in PAH metabolite levels in the Czech population. Legislative measures occurred between sampling periods, including restricting smoking and the Air Protection Act.MethodsTen metabolites of PAHs were measured in urine samples collected in 2011-2012 from mothers and children from DEMOCOPHES-CZ study (N = 235) and in 2019-2020 from children, teenagers, and young adults from CELSPAC studies (N = 809). Multivariate linear regression, Kruskal-Wallis ANOVA, and Mann-Whitney test (MW) were used to investigate differences in OH-PAHs between periods, age categories, and exposure determinants.ResultsMedian concentrations significantly decreased between 2011-2020 by 30-35% for 1-OH-NAP, 2-and 3-OH-FLUO, 85% for 1-OH-PHE, and 44% for 2/3-OH-PHE, while 2-OH-NAP increased by 29% in non-smoking adults. In children, median concentrations of all metabolites decreased by 10-51%, with 2-OH-NAP rising by 49%. Smokers showed the largest differences, with significant decreases of 46-59% in the median concentrations of 2-OH-NAP, 2/3-OH-PHE, 9-OH-PHE, and 1-OH-PYR, and 76-91% in OH-FLUOs, 1-OH-NAP, and 1-OH-PHE. Fish and offal consumption, season, locality, and type of cooking were significant factors associated with levels of OH-PAHs, explaining 4-9% of the variability. Smoking was the main contributor in 2011, explaining up to 45% variability; no difference was found between smokers and non-smokers in 2019. New reference values of OH-PAHs in urine were calculated for the Czech population.ImpactThis study analyses the temporal trends of OH-PAHs in the population in the context of introduced legislative measures. In addition, it examines OH-PAH exposure in children, adolescents, and young adults in relation to lifestyle factors and establishes new reference values for polycyclic aromatic hydrocarbons that are important for public health decision-making. Biomonitoring over time is an essential tool for establishing new measures to protect public health.Created in BioRender. Komprdova, K. (2025) https://BioRender.com/u10q831.ImpactThis study analyses the temporal trends of OH-PAHs in the population in the context of introduced legislative measures. In addition, it examines OH-PAH exposure in children, adolescents, and young adults in relation to lifestyle factors and establishes new reference values for polycyclic aromatic hydrocarbons that are important for public health decision-making. Biomonitoring over time is an essential tool for establishing new measures to protect public health.Created in BioRender. Komprdova, K. (2025) https://BioRender.com/u10q831.
ER  -

SMETANOVÁ, Soňa; Akrem JBEBLI; Jiří KOHOUTEK; Vladimira PUKLOVA; Milena CERNA; Andrea KRSKOVA; Martin ZVONAŘ; Zdenko REGULI; Lenka ANDRÝSKOVÁ; Pavel PILER; Petra PŘIBYLOVÁ; Jana KLÁNOVÁ; Elliott James PRICE a Klára KOMPRDOVÁ. Changing pattern of exposure to polycyclic aromatic hydrocarbons over time in the Central European population. \textit{Journal of Exposure Science and Environmental Epidemiology}. SPRINGER NATURE, 2026, roč.~36, č.~1, s.~184-198. ISSN~1559-0631. Dostupné z: https://doi.org/10.1038/s41370-025-00793-z.

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