Stressing about stress: Examining dental cortisol
concentrations in teeth with dental enamel hypoplasia

J 2026

Stressing about stress: Examining dental cortisol concentrations in teeth with dental enamel hypoplasia

QUADE, Leslie; Petra BENCÚROVÁ a Miroslav KRÁLÍK

Základní údaje

Originální název

Stressing about stress: Examining dental cortisol concentrations in teeth with dental enamel hypoplasia

Autoři

QUADE, Leslie; Petra BENCÚROVÁ a Miroslav KRÁLÍK

Vydání

International Journal of Paleopathology, Elsevier, 2026, 1879-9817

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10700 1.7 Other natural sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Stránky vydavatele

Impakt faktor

Impact factor: 1.500 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

Vývoj v raném dětství; Trvalé a dočasné zuby; Steroidní hormony; Středověk; Paleosteroidy

Klíčová slova anglicky

Early childhood development; Permanent and deciduous teeth; Steroid hormones; Medieval Period; Paleo-steroids

Štítky

14314070, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 2. 2026 15:27, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Objective: The ‘stress’ hormone cortisol has recently been identified in human teeth, representing a potential method for assessing stress in past populations. In this study, dental cortisol concentrations were analyzed in teeth with dental enamel hypoplasia (DEH) to advance knowledge about this new method for detecting stress in archaeological skeletons. Materials: Ten teeth with DEH were selected from nine individuals buried in the ‘Brno-Vídeňská Street’ cemetery (11th-12th century). Methods: DEH were classified by type and number. Cortisol was assessed in circumpulpal dentine, primary dentine and enamel (n = 26) through enzyme-linked immunosorbent assay. Results: Cortisol was detected in eight of 10 teeth (80.0 %) and 15 of 26 samples (57.7 %), most frequently in enamel, with concentrations ranging from 0.011 to 0.194 μg/dL. Teeth with multiple linear or cuspal enamel hypoplasia were more likely to generate quantifiable cortisol. Conclusions: This analysis demonstrates a possible relationship between cortisol and DEH, especially when multiple defects are present. However, many samples did not have detectable cortisol, suggesting further research is necessary to explore if and how cortisol relates or contributes to DEH formation. Significance: This is the first study to examine cortisol concentrations in teeth with DEH, advancing cortisol research. Limitations: Sample sizes are small and included different tooth types with varying preservation. Suggestions for further research: Future research should investigate diagenesis and compare cortisol in teeth with and without DEH, focusing on enamel. Mass spectrometry will provide greater sensitivity in future analyses.

Návaznosti

EF18_053/0016952, projekt VaV

Název: Postdoc2MUNI

Přiložené soubory

2548488.pdf

Citovat

QUADE, Leslie; Petra BENCÚROVÁ a Miroslav KRÁLÍK. Stressing about stress: Examining dental cortisol concentrations in teeth with dental enamel hypoplasia. International Journal of Paleopathology. Elsevier, 2026, roč. 52, March, s. 102-107. ISSN 1879-9817. Dostupné z: https://doi.org/10.1016/j.ijpp.2026.01.004.

@article{2548488,
   author = {Quade, Leslie and Bencúrová, Petra and Králík, Miroslav},
   article_number = {March},
   doi = {https://doi.org/10.1016/j.ijpp.2026.01.004},
   keywords = {Early childhood development; Permanent and deciduous teeth; Steroid hormones; Medieval Period; Paleo-steroids},
   language = {eng},
   issn = {1879-9817},
   journal = {International Journal of Paleopathology},
   title = {Stressing about stress: Examining dental cortisol concentrations in teeth with dental enamel hypoplasia},
   url = {https://www-sciencedirect-com.ezproxy.muni.cz/science/article/pii/S1879981726000045},
   volume = {52},
   year = {2026}
}

TY  - JOUR
ID  - 2548488
AU  - Quade, Leslie - Bencúrová, Petra - Králík, Miroslav
PY  - 2026
TI  - Stressing about stress: Examining dental cortisol concentrations in teeth with dental enamel hypoplasia
JF  - International Journal of Paleopathology
VL  - 52
IS  - March
SP  - 102-107
EP  - 102-107
PB  - Elsevier
SN  - 18799817
KW  - Early childhood development
KW  - Permanent and deciduous teeth
KW  - Steroid hormones
KW  - Medieval Period
KW  - Paleo-steroids
UR  - https://www-sciencedirect-com.ezproxy.muni.cz/science/article/pii/S1879981726000045
N2  - Objective: The ‘stress’ hormone cortisol has recently been identified in human teeth, representing a potential method for assessing stress in past populations. In this study, dental cortisol concentrations were analyzed in teeth with dental enamel hypoplasia (DEH) to advance knowledge about this new method for detecting stress in archaeological skeletons. Materials: Ten teeth with DEH were selected from nine individuals buried in the ‘Brno-Vídeňská Street’ cemetery (11th-12th century). Methods: DEH were classified by type and number. Cortisol was assessed in circumpulpal dentine, primary dentine and enamel (n = 26) through enzyme-linked immunosorbent assay. Results: Cortisol was detected in eight of 10 teeth (80.0 %) and 15 of 26 samples (57.7 %), most frequently in enamel, with concentrations ranging from 0.011 to 0.194 μg/dL. Teeth with multiple linear or cuspal enamel hypoplasia were more likely to generate quantifiable cortisol. Conclusions: This analysis demonstrates a possible relationship between cortisol and DEH, especially when multiple defects are present. However, many samples did not have detectable cortisol, suggesting further research is necessary to explore if and how cortisol relates or contributes to DEH formation. Significance: This is the first study to examine cortisol concentrations in teeth with DEH, advancing cortisol research. Limitations: Sample sizes are small and included different tooth types with varying preservation. Suggestions for further research: Future research should investigate diagenesis and compare cortisol in teeth with and without DEH, focusing on enamel. Mass spectrometry will provide greater sensitivity in future analyses.
ER  -

QUADE, Leslie; Petra BENCÚROVÁ a Miroslav KRÁLÍK. Stressing about stress: Examining dental cortisol concentrations in teeth with dental enamel hypoplasia. \textit{International Journal of Paleopathology}. Elsevier, 2026, roč.~52, March, s.~102-107. ISSN~1879-9817. Dostupné z: https://doi.org/10.1016/j.ijpp.2026.01.004.

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