Ventral and Dorsal Language Pathways in Patients with Lewy
Bodies: an fMRI Study of Syntactic Sentence Processing

a 2025

Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing

NOVÁKOVÁ, Ľubomíra; Martin GAJDOŠ; Daniel CARBOL a Irena REKTOROVÁ

Základní údaje

Originální název

Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing

Autoři

NOVÁKOVÁ, Ľubomíra; Martin GAJDOŠ ; Daniel CARBOL a Irena REKTOROVÁ

Vydání

2025 International Congress of Parkinson's Disease and Movement Disorders, Honolulu, 2025

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/25:00143678

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Cognitive dysfunction; Functional magnetic resonance imaging (fMRI); Lewy bodies

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2026 13:02, Mgr. Eva Dubská

Anotace

V originále

Language impairments are common yet often underrecognized in patients with Lewy body diseases (LBDs), even at the stage of mild cognitive impairment (MCI-LB). This study aimed to identify specific deficits in the comprehension of syntactically complex sentences in MCI-LB patients and to determine their neural correlates within dorsal and ventral language pathways using functional connectivity analysis. Twenty-five MCI-LB patients and 25 healthy controls (HC) underwent task-based fMRI during the Test of Sentence Comprehension (ToSC). Functional connectivity between predefined regions of interest in dorsal and ventral language streams was assessed using psychophysiological interaction (PPI) analysis with FDR-corrected statistical thresholds. MCI-LB patients showed significantly lower ToSC performance compared to HC. Connectivity analyses revealed reduced functional coupling predominantly within the dorsal language pathway during processing of noncanonical syntactic structures. Specifically, decreased connectivity was observed between the anterior superior temporal gyrus and frontal language regions in MCI-LB patients relative to controls. These findings indicate that impaired sentence comprehension in MCI-LB is associated with disrupted dorsal language network connectivity. Alterations in frontotemporal connectivity may represent a potential neuroimaging marker of cognitive decline in LBDs and contribute to understanding language dysfunction in synucleinopathies.

Návaznosti

EH23_025/0008726, projekt VaV

Název: Celý život s jazykem: povaha a ontogeneze jazykové komunikace (LangInLife)

Přiložené soubory

Novakova__International_Congress__2025.pdf

Citovat

NOVÁKOVÁ, Ľubomíra; Martin GAJDOŠ; Daniel CARBOL a Irena REKTOROVÁ. Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing. In 2025 International Congress of Parkinson's Disease and Movement Disorders, Honolulu. 2025.

@proceedings{2553911,
   author = {Nováková, Ľubomíra and Gajdoš, Martin and Carbol, Daniel and Rektorová, Irena},
   booktitle = {2025 International Congress of Parkinson's Disease and Movement Disorders, Honolulu},
   keywords = {Cognitive dysfunction; Functional magnetic resonance imaging (fMRI); Lewy bodies},
   language = {eng},
   title = {Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing},
   url = {https://www.movementdisorders.org/Moving-Along/Preview-2025-International-Congress-scientific-program},
   year = {2025}
}

TY  - CONF
ID  - 2553911
AU  - Nováková, Ľubomíra - Gajdoš, Martin - Carbol, Daniel - Rektorová, Irena
PY  - 2025
TI  - Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing
KW  - Cognitive dysfunction
KW  - Functional magnetic resonance imaging (fMRI)
KW  - Lewy bodies
UR  - https://www.movementdisorders.org/Moving-Along/Preview-2025-International-Congress-scientific-program
N2  - Language impairments are common yet often underrecognized in patients with Lewy body diseases (LBDs), even at the stage of mild cognitive impairment (MCI-LB). This study aimed to identify specific deficits in the comprehension of syntactically complex sentences in MCI-LB patients and to determine their neural correlates within dorsal and ventral language pathways using functional connectivity analysis. Twenty-five MCI-LB patients and 25 healthy controls (HC) underwent task-based fMRI during the Test of Sentence Comprehension (ToSC). Functional connectivity between predefined regions of interest in dorsal and ventral language streams was assessed using psychophysiological interaction (PPI) analysis with FDR-corrected statistical thresholds. MCI-LB patients showed significantly lower ToSC performance compared to HC. Connectivity analyses revealed reduced functional coupling predominantly within the dorsal language pathway during processing of noncanonical syntactic structures. Specifically, decreased connectivity was observed between the anterior superior temporal gyrus and frontal language regions in MCI-LB patients relative to controls. These findings indicate that impaired sentence comprehension in MCI-LB is associated with disrupted dorsal language network connectivity. Alterations in frontotemporal connectivity may represent a potential neuroimaging marker of cognitive decline in LBDs and contribute to understanding language dysfunction in synucleinopathies.
ER  -

NOVÁKOVÁ, Ľubomíra; Martin GAJDOŠ; Daniel CARBOL a Irena REKTOROVÁ. Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing. In \textit{2025 International Congress of Parkinson's Disease and Movement Disorders, Honolulu}. 2025.

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