D 2000

A modified perfusion system for pharmacological studies in isolated hearts

NOVÁKOVÁ, Marie, Jiří MOUDR and Pavel BRAVENÝ

Basic information

Original name

A modified perfusion system for pharmacological studies in isolated hearts

Name in Czech

Upravený perfuzní systém pro farmakologické studie na izolovaných srdcích

Authors

NOVÁKOVÁ, Marie (203 Czech Republic, guarantor), Jiří MOUDR (203 Czech Republic) and Pavel BRAVENÝ (203 Czech Republic)

Edition

15. vyd. Brno, Analysis of Biomedical Signals and Images, Biosignal 2000, p. 162-164, 2000

Publisher

Vutium Press, Brno University of Technology

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/00:00003298

Organization unit

Faculty of Medicine

ISBN

80-214-1610-6

Keywords in English

perfusion set-up;isolated heart;pharmacological studies

Tags

International impact, Reviewed
Změněno: 25/6/2009 19:45, prof. MUDr. Marie Nováková, Ph.D.

Abstract

V originále

A modification of the aortic perfusion technique for studying completely isolated mammalian heart convenient for pharmacological studies is presented. The technique enables the experimenter to obtain valuable data from spontaneously beating heart of different species of laboratory animals. Several parameters are recorded (LV pressure, electrogram) using a special software. This system makes it possible to use one heart for several experiments and thus to minimize the number of sacrificed animals.

In Czech

Práce popisuje perfuzní aparát speciálně upravený pro farmakologické studie na izolovaných srdcích. Set umožňuje bezdotykový záznam elektrogramu a tlaku v levé komoře pomocí balonku.

Links

GA305/98/P206, research and development project
Name: Ovlivnění kontraktility a membránových proudů savčího myokardu prostřednictvím sigma receptorů
Investor: Czech Science Foundation, The effect of sigma receptors on contractility and membrane currents in mammalian myocardium