| SKALNÍKOVÁ, Magdalena, Stanislav KOZUBEK, Emilie LUKÁŠOVÁ, Eva BÁRTOVÁ, Pavla JIRSOVÁ, Alena CAFOURKOVÁ, Irena KOUTNÁ and Michal KOZUBEK. Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation. Chromosome Research. Dordrecht: Kluwer Academic, 2000, vol. 8, No 6, p. 487-499. ISSN 0967-3849. |
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@article{346312,
author = {Skalníková, Magdalena and Kozubek, Stanislav and Lukášová, Emilie and Bártová, Eva and Jirsová, Pavla and Cafourková, Alena and Koutná, Irena and Kozubek, Michal},
article_location = {Dordrecht},
article_number = {6},
keywords = {cell cycle; chromosomes; differentiation; image analysis; nuclear structure},
language = {eng},
issn = {0967-3849},
journal = {Chromosome Research},
title = {Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation},
url = {http://www.fi.muni.cz/lom/abstracts/lom007.shtml},
volume = {8},
year = {2000}
}
TY - JOUR
ID - 346312
AU - Skalníková, Magdalena - Kozubek, Stanislav - Lukášová, Emilie - Bártová, Eva - Jirsová, Pavla - Cafourková, Alena - Koutná, Irena - Kozubek, Michal
PY - 2000
TI - Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation
JF - Chromosome Research
VL - 8
IS - 6
SP - 487
EP - 487
PB - Kluwer Academic
SN - 09673849
KW - cell cycle
KW - chromosomes
KW - differentiation
KW - image analysis
KW - nuclear structure
UR - http://www.fi.muni.cz/lom/abstracts/lom007.shtml
N2 - Higher-order compartments of nuclear chromatin have been defined according to the replication timing, transcriptional activity, and information content (Ferreira et al. 1997, Sadoni et al. 1999). The results presented in this work contribute to this model of nuclear organization. Using different human blood cells, nuclear positioning of genes, centromeres, and whole chromosomes was investigated. Genes are located mostly in the interior of cell nuclei; centromeres are located near the nuclear periphery in agreement with the definition of the higher-order compartments. Genetic loci are found in specific subregions of cell nuclei which form distinct layers at defined centre-of-nucleus to locus distances. Inside these layers, the genetic loci are distributed randomly. Some chromosomes are polarized with genes located in the inner parts of the nucleus and centromere located on the nuclear periphery; polar organization was not found for some other chromosomes.
ER -
SKALNÍKOVÁ, Magdalena, Stanislav KOZUBEK, Emilie LUKÁŠOVÁ, Eva BÁRTOVÁ, Pavla JIRSOVÁ, Alena CAFOURKOVÁ, Irena KOUTNÁ and Michal KOZUBEK. Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation. \textit{Chromosome Research}. Dordrecht: Kluwer Academic, 2000, vol.~8, No~6, p.~487-499. ISSN~0967-3849.
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