| VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ a Miloslav KUKLETA. Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study. Homeostasis. Praha: Found. of Stress Prev. and Behav. Med., 2000, roč. 40, 3-4, s. 147-148. ISSN 0960-7560. |
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@article{349033,
author = {Vašků, Anna and Izakovičová Hollá, Lydie and Kukleta, Miloslav},
article_location = {Praha},
article_number = {3-4},
keywords = {angiotensinogen; ACE; TABP score; hypertension; case-control study},
language = {eng},
issn = {0960-7560},
journal = {Homeostasis},
title = {Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study},
volume = {40},
year = {2000}
}
TY - JOUR
ID - 349033
AU - Vašků, Anna - Izakovičová Hollá, Lydie - Kukleta, Miloslav
PY - 2000
TI - Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study
JF - Homeostasis
VL - 40
IS - 3-4
SP - 147
EP - 147
PB - Found. of Stress Prev. and Behav. Med.
SN - 09607560
KW - angiotensinogen
KW - ACE
KW - TABP score
KW - hypertension
KW - case-control study
N2 - To appraise the true quality of subject selection for case-control studies, the double genotype (I/D ACE and M235T AGT) was chosen because of its association with Type A Behavior Pattern (TABP) score (p=0.0299. The genotypes with opposite values of TABP score IIMT- 22.4 and DDMT-(-19.5) were found to be more frequent in the first hundred of subjects in two groups. The difference was stronger when data of both groups were calculated together (Group-1 + Group-2, p=0.0002). No significant difference was found between frequencies of genotype with opposite values of TABP score in any comparison of either two normotensive or three hypertensive groups. In practice, the number of 100 subjects in the group is considered to be sufficient for the gene association studies. Our results demonstrate that this assumption is wrong when subjects for genetic studies are recruited from one office.
ER -
VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ a Miloslav KUKLETA. Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study. \textit{Homeostasis}. Praha: Found. of Stress Prev. and Behav. Med., 2000, roč.~40, 3-4, s.~147-148. ISSN~0960-7560.
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