Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ and Miloslav KUKLETA. Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study. Homeostasis. Praha: Found. of Stress Prev. and Behav. Med., 2000, vol. 40, 3-4, p. 147-148. ISSN 0960-7560.

Basic information

• Original name: Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study
• Authors: VAŠKŮ, Anna (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Miloslav KUKLETA (203 Czech Republic).
• Edition: Homeostasis, Praha, Found. of Stress Prev. and Behav. Med. 2000, 0960-7560.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/00:00002865
• Organization unit: Faculty of Medicine
• Keywords in English: angiotensinogen; ACE; TABP score; hypertension; case-control study
• Tags: ACE, angiotensinogen, case-control study, Hypertension, TABP score

Abstract

To appraise the true quality of subject selection for case-control studies, the double genotype (I/D ACE and M235T AGT) was chosen because of its association with Type A Behavior Pattern (TABP) score (p=0.0299. The genotypes with opposite values of TABP score IIMT- 22.4 and DDMT-(-19.5) were found to be more frequent in the first hundred of subjects in two groups. The difference was stronger when data of both groups were calculated together (Group-1 + Group-2, p=0.0002). No significant difference was found between frequencies of genotype with opposite values of TABP score in any comparison of either two normotensive or three hypertensive groups. In practice, the number of 100 subjects in the group is considered to be sufficient for the gene association studies. Our results demonstrate that this assumption is wrong when subjects for genetic studies are recruited from one office.

Links

• GA306/93/2192, research and development project: Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension

• MSM 141100002, plan (intention): Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

• VS96097, research and development project: Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases