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@article{354992,
author = {Paulová, Hana and Bochořáková, Hana and Slanina, Jiří and Táborská, Eva},
article_location = {BRD},
article_number = {10(1)},
keywords = {baicalin; hydroxyl radical;},
language = {eng},
issn = {0939-9488},
journal = {Pharm.Pharmacol.Lett.2000},
title = {Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method},
volume = {2000},
year = {2000}
}
TY - JOUR
ID - 354992
AU - Paulová, Hana - Bochořáková, Hana - Slanina, Jiří - Táborská, Eva
PY - 2000
TI - Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method
JF - Pharm.Pharmacol.Lett.2000
VL - 2000
IS - 10(1)
SP - 27-30
EP - 27-30
PB - Medpharm
SN - 09399488
KW - baicalin
KW - hydroxyl radical;
N2 - Abstract. The ability of baicalin, the flavonoid from the roots of the medicinal plant Scutellaria baicalensis, to scavenge hydroxyl radicals was studied with using sensitive HPLC method. The hydroxyl radicals were generated by UV photolysis of H2O2 and salicylic acid was used as a trapping agent. The hydroxylation products of salicylic acid, 2,3- and 2,5- dihydroxybenzoic acids, were detected by HPLC. Baicalin caused decrease in the production of 2,3- and 2,5 - dihydroxybenzoic acid in a concentration dependent manner and did not affect peaks of the standard of these dihydroxybenzoic acids. These results indicate that baicalin scavenges hydroxyl radicals generated by UV photolysis of H2O2. IC(50) values were estimated.
ER -
PAULOVÁ, Hana, Hana BOCHOŘÁKOVÁ, Jiří SLANINA and Eva TÁBORSKÁ. Evaluation of hydroxyl radical-scavenging activity of baicalin using HPLC method. \textit{Pharm.Pharmacol.Lett.2000}. BRD: Medpharm, 2000, vol.~2000, 10(1), p.~27-30. ISSN~0939-9488.
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