| MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER, Hana HRSTKOVÁ a Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias. Blood Cells, Molecules and Diseases. Orlando, Florida: Academic Press, 2000, roč. 26, č. 5, s. 534-539. ISSN 1079-9796. |
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@article{356171,
author = {Maláska, Jan and Skleničková, Marie and Krejčí, Kateřina and Fajkusová, Lenka and Bajer, Milan and Hrstková, Hana and Fajkus, Jiří},
article_location = {Orlando, Florida},
article_number = {5},
keywords = {acute leukemias; telomerase; in situ analysis of telomeres; chemotherapy; predictive factors},
language = {eng},
issn = {1079-9796},
journal = {Blood Cells, Molecules and Diseases},
title = {Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias},
volume = {26},
year = {2000}
}
TY - JOUR
ID - 356171
AU - Maláska, Jan - Skleničková, Marie - Krejčí, Kateřina - Fajkusová, Lenka - Bajer, Milan - Hrstková, Hana - Fajkus, Jiří
PY - 2000
TI - Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
JF - Blood Cells, Molecules and Diseases
VL - 26
IS - 5
SP - 534
EP - 534
PB - Academic Press
SN - 10799796
KW - acute leukemias
KW - telomerase
KW - in situ analysis of telomeres
KW - chemotherapy
KW - predictive factors
N2 - Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.
ER -
MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER, Hana HRSTKOVÁ a Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias. \textit{Blood Cells, Molecules and Diseases}. Orlando, Florida: Academic Press, 2000, roč.~26, č.~5, s.~534-539. ISSN~1079-9796.
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