Telomerase Activity and Expresion and Telomere Analysis in Situ
in the Course of Treatment of Childhood Leukemias

J 2000

Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias

MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER et. al.

Základní údaje

Originální název

Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias

Autoři

MALÁSKA, Jan (203 Česká republika), Marie SKLENIČKOVÁ (203 Česká republika), Kateřina KREJČÍ, Lenka FAJKUSOVÁ (203 Česká republika), Milan BAJER (203 Česká republika), Hana HRSTKOVÁ (203 Česká republika) a Jiří FAJKUS (203 Česká republika, garant)

Vydání

Blood Cells, Molecules and Diseases, Orlando, Florida, Academic Press, 2000, 1079-9796

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.897

Kód RIV

RIV/00216224:14310/00:00004094

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000165787500158

Klíčová slova anglicky

acute leukemias; telomerase; in situ analysis of telomeres; chemotherapy; predictive factors

Štítky

acute leukemias, chemotherapy, predictive factors, Telomerase

Změněno: 24. 6. 2008 16:01, prof. RNDr. Jiří Fajkus, CSc.

Anotace

V originále

Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.

Návaznosti

GA301/99/0045, projekt VaV

Název: Dynamika telomer u vybraných typů solidních maligních onemocnění

Investor: Grantová agentura ČR, Dynamika telomer u vybraných typů solidních maligních onemocnění

MSM 143100008, záměr

Název: Genomy a jejich funkce

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Genomy a jejich funkce

VS97032, projekt VaV

Název: Analýza biologicky významných molekulárních komplexů

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Analýza biologicky významných molekulárních komplexů

Citovat

MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER, Hana HRSTKOVÁ a Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias. Blood Cells, Molecules and Diseases. Orlando, Florida: Academic Press, 2000, roč. 26, č. 5, s. 534-539. ISSN 1079-9796.

@article{356171,
   author = {Maláska, Jan and Skleničková, Marie and Krejčí, Kateřina and Fajkusová, Lenka and Bajer, Milan and Hrstková, Hana and Fajkus, Jiří},
   article_location = {Orlando, Florida},
   article_number = {5},
   keywords = {acute leukemias; telomerase; in situ analysis of telomeres; chemotherapy; predictive factors},
   language = {eng},
   issn = {1079-9796},
   journal = {Blood Cells, Molecules and Diseases},
   title = {Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias},
   volume = {26},
   year = {2000}
}

TY  - JOUR
ID  - 356171
AU  - Maláska, Jan - Skleničková, Marie - Krejčí, Kateřina - Fajkusová, Lenka - Bajer, Milan - Hrstková, Hana - Fajkus, Jiří
PY  - 2000
TI  - Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
JF  - Blood Cells, Molecules and Diseases
VL  - 26
IS  - 5
SP  - 534
EP  - 534
PB  - Academic Press
SN  - 10799796
KW  - acute leukemias
KW  - telomerase
KW  - in situ analysis of telomeres
KW  - chemotherapy
KW  - predictive factors
N2  - Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.
ER  -

MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER, Hana HRSTKOVÁ a Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias. \textit{Blood Cells, Molecules and Diseases}. Orlando, Florida: Academic Press, 2000, roč.~26, č.~5, s.~534-539. ISSN~1079-9796.

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