The C766T low-density lipoprotein receptor related protein
polymorphism and coronary artery disease, plasma lipoproteins,
and longevity in the Czech population

J 2001

The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population

BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Lubomír ELBL, Anna VAŠKŮ et. al.

Basic information

Original name

The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population

Authors

BENEŠ, Petr (203 Czech Republic, guarantor), Jan MUŽÍK (203 Czech Republic), Jaroslav BENEDÍK (203 Czech Republic), Lubomír ELBL (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic), Lenka ŠIŠKOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Journal of Molecular Medicine, Německo, Springer, 2001, 0946-2716

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.498

RIV identification code

RIV/00216224:14310/01:00003145

Organization unit

Faculty of Science

UT WoS

000168385300006

Keywords in English

Low density lipoprotein receptor related protein; Plasminogen activator inhibitor 1; Coronary artery disease; Genetic polymorphism; Longevity; Plasma lipoproteins

Abstract

V originále

Our results demonstrate that the T allele of the C766T LRP polymorphism is negatively related to longevity, and that it increases the risk of CAD development in subjects with the 5G/5G PAI-1 genotype. No significant association was observed between the LRP or PAI-1 polymorphisms and plasma lipoprotein levels in the CAD patients.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

VS96097, research and development project

Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases

Citovat

BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Lubomír ELBL, Anna VAŠKŮ, Lenka ŠIŠKOVÁ, Vladimír ZNOJIL and Jiří VÁCHA. The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population. Journal of Molecular Medicine. Německo: Springer, 2001, vol. 79, 2/3, p. 116-120. ISSN 0946-2716.

@article{359373,
   author = {Beneš, Petr and Mužík, Jan and Benedík, Jaroslav and Elbl, Lubomír and Vašků, Anna and Šišková, Lenka and Znojil, Vladimír and Vácha, Jiří},
   article_location = {Německo},
   article_number = {2/3},
   keywords = {Low density lipoprotein receptor related protein; Plasminogen activator inhibitor 1; Coronary artery disease; Genetic polymorphism; Longevity; Plasma lipoproteins},
   language = {eng},
   issn = {0946-2716},
   journal = {Journal of Molecular Medicine},
   title = {The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population},
   volume = {79},
   year = {2001}
}

TY  - JOUR
ID  - 359373
AU  - Beneš, Petr - Mužík, Jan - Benedík, Jaroslav - Elbl, Lubomír - Vašků, Anna - Šišková, Lenka - Znojil, Vladimír - Vácha, Jiří
PY  - 2001
TI  - The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population
JF  - Journal of Molecular Medicine
VL  - 79
IS  - 2/3
SP  - 116
EP  - 116
PB  - Springer
SN  - 09462716
KW  - Low density lipoprotein receptor related protein
KW  - Plasminogen activator inhibitor 1
KW  - Coronary artery disease
KW  - Genetic polymorphism
KW  - Longevity
KW  - Plasma lipoproteins
N2  - Our results demonstrate that the T allele of the C766T LRP polymorphism is negatively related to longevity, and that it increases the risk of CAD development in subjects with the 5G/5G PAI-1 genotype. No significant association was observed between the LRP or PAI-1 polymorphisms and plasma lipoprotein levels in the CAD patients.
ER  -

BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Lubomír ELBL, Anna VAŠKŮ, Lenka ŠIŠKOVÁ, Vladimír ZNOJIL and Jiří VÁCHA. The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population. \textit{Journal of Molecular Medicine}. Německo: Springer, 2001, vol.~79, 2/3, p.~116-120. ISSN~0946-2716.

Detailed Information on Publication Record