| BENEŠ, Petr, Kateřina KAŇKOVÁ, Jan MUŽÍK, Ladislav GROCH, Jaroslav BENEDÍK, Lubomír ELBL, Lydie IZAKOVIČOVÁ HOLLÁ, Anna VAŠKŮ, Vladimír ZNOJIL and Jiří VÁCHA. Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population. Molecular Genetics and Metabolism. San Diego: Academic Press, 2001, vol. 2, No 73, p. 188-195. ISSN 1096-7192. |
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@article{360573,
author = {Beneš, Petr and Kaňková, Kateřina and Mužík, Jan and Groch, Ladislav and Benedík, Jaroslav and Elbl, Lubomír and Izakovičová Hollá, Lydie and Vašků, Anna and Znojil, Vladimír and Vácha, Jiří},
article_location = {San Diego},
article_number = {73},
keywords = {gene; polymorphism; MTHFR; CAD; hypertension; diabetes},
language = {eng},
issn = {1096-7192},
journal = {Molecular Genetics and Metabolism},
title = {Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population},
volume = {2},
year = {2001}
}
TY - JOUR
ID - 360573
AU - Beneš, Petr - Kaňková, Kateřina - Mužík, Jan - Groch, Ladislav - Benedík, Jaroslav - Elbl, Lubomír - Izakovičová Hollá, Lydie - Vašků, Anna - Znojil, Vladimír - Vácha, Jiří
PY - 2001
TI - Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population
JF - Molecular Genetics and Metabolism
VL - 2
IS - 73
SP - 188
EP - 188
PB - Academic Press
SN - 10967192
KW - gene
KW - polymorphism
KW - MTHFR
KW - CAD
KW - hypertension
KW - diabetes
N2 - Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.
ER -
BENEŠ, Petr, Kateřina KAŇKOVÁ, Jan MUŽÍK, Ladislav GROCH, Jaroslav BENEDÍK, Lubomír ELBL, Lydie IZAKOVIČOVÁ HOLLÁ, Anna VAŠKŮ, Vladimír ZNOJIL and Jiří VÁCHA. Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population. \textit{Molecular Genetics and Metabolism}. San Diego: Academic Press, 2001, vol.~2, No~73, p.~188-195. ISSN~1096-7192.
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