Lack of an Association of a Single Nucleotide Polymorphism in
the Promoter of the Matrix Metalloproteinase-1 Gene in Czech
Women with Pregnancy-Induced Hypertension.

J 2001

Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.

JURAJDA, Michal, Kateřina KAŇKOVÁ, Jan MUŽÍK, Vít UNZEITIG, Marie DRÁBKOVÁ et. al.

Basic information

Original name

Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.

Authors

JURAJDA, Michal (203 Czech Republic, guarantor), Kateřina KAŇKOVÁ (203 Czech Republic), Jan MUŽÍK (203 Czech Republic), Vít UNZEITIG (203 Czech Republic), Marie DRÁBKOVÁ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Gynecologic and Obstetric Investigation, Basel, S. Karger AG, 2001, 0378-7346

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.884

RIV identification code

RIV/00216224:14110/01:00004151

Organization unit

Faculty of Medicine

UT WoS

000171615500010

Keywords in English

pregnancy-induced hypertension; preeclampsia; genetic polymorphism; matrix metalloproteinase 1

Abstract

V originále

In preeclampsia the cytotrophoblast invasion of the decidual vessels is reduced. The endothelia in the decidual vessels may influence the cytotrophoblast invasion and remodeling of decidual spiral arteries. The decidual endothelial cells from preeclamptic placentas produce less MMP1 than those from normal placentas. MMPs form group of enzymes that is capable of degrading components of extracellular matrix components. The present study investigated the prevalence and possible association of an insertion of guanine in the promoter of the MMP1 gene with pregnancy-induced hypertension, preeclampsia and eclampsia in the Czech population. This was a case control study. No differences were observed in genotype frequencies between cases and controls. The insertion of the guanine in the promoter of the MMP1 gene does not appear to increase the risk of development of pregnancy-induced hypertension, preeclampsia and eclampsia.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

VS96097, research and development project

Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases

Citovat

JURAJDA, Michal, Kateřina KAŇKOVÁ, Jan MUŽÍK, Vít UNZEITIG, Marie DRÁBKOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ and Jiří VÁCHA. Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension. Gynecologic and Obstetric Investigation. Basel: S. Karger AG, 2001, vol. 52, No 2, p. 124-127. ISSN 0378-7346.

@article{360632,
   author = {Jurajda, Michal and Kaňková, Kateřina and Mužík, Jan and Unzeitig, Vít and Drábková, Marie and Izakovičová Hollá, Lydie and Vácha, Jiří},
   article_location = {Basel},
   article_number = {2},
   keywords = {pregnancy-induced hypertension; preeclampsia; genetic polymorphism; matrix metalloproteinase 1},
   language = {eng},
   issn = {0378-7346},
   journal = {Gynecologic and Obstetric Investigation},
   title = {Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.},
   volume = {52},
   year = {2001}
}

TY  - JOUR
ID  - 360632
AU  - Jurajda, Michal - Kaňková, Kateřina - Mužík, Jan - Unzeitig, Vít - Drábková, Marie - Izakovičová Hollá, Lydie - Vácha, Jiří
PY  - 2001
TI  - Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.
JF  - Gynecologic and Obstetric Investigation
VL  - 52
IS  - 2
SP  - 124
EP  - 124
PB  - S. Karger AG
SN  - 03787346
KW  - pregnancy-induced hypertension
KW  - preeclampsia
KW  - genetic polymorphism
KW  - matrix metalloproteinase 1
N2  - In preeclampsia the cytotrophoblast invasion of the decidual vessels is reduced. The endothelia in the decidual vessels may influence the cytotrophoblast invasion and remodeling of decidual spiral arteries. The decidual endothelial cells from preeclamptic placentas produce less MMP1 than those from normal placentas. MMPs form group of enzymes that is capable of degrading components of extracellular matrix components. The present study investigated the prevalence and possible association of an insertion of guanine in the promoter of the MMP1 gene with pregnancy-induced hypertension, preeclampsia and eclampsia in the Czech population. This was a case control study. No differences were observed in genotype frequencies between cases and controls. The insertion of the guanine in the promoter of the MMP1 gene does not appear to increase the risk of development of pregnancy-induced hypertension, preeclampsia and eclampsia.
ER  -

JURAJDA, Michal, Kateřina KAŇKOVÁ, Jan MUŽÍK, Vít UNZEITIG, Marie DRÁBKOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ and Jiří VÁCHA. Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension. \textit{Gynecologic and Obstetric Investigation}. Basel: S. Karger AG, 2001, vol.~52, No~2, p.~124-127. ISSN~0378-7346.

Detailed Information on Publication Record