New and facile method of preparation of the anti-HIV-1 agent,
1,3-dicaffeoylquinic acid

J 2001

New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid

SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA et. al.

Základní údaje

Originální název

New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid

Název česky

Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny

Autoři

SLANINA, Jiří (203 Česká republika, garant), Eva TÁBORSKÁ (203 Česká republika), Hana BOCHOŘÁKOVÁ (203 Česká republika), Iva SLANINOVÁ (203 Česká republika), Otakar HUMPA (203 Česká republika), W. Edward ROBINSON a Karl H. SCHRAM

Vydání

Tetrahedron Letters, Oxford, Pergamon - Elsevier Science, 2001, 0040-4039

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.280

Kód RIV

RIV/00216224:14110/01:00004264

Organizační jednotka

Lékařská fakulta

UT WoS

000168404000036

Klíčová slova anglicky

Antivirals; biologically active compounds; isomerisation; phenolics; tannins

Štítky

Antivirals, biologically active compounds, isomerisation, phenolics, tannins

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 6. 2009 00:20, Mgr. Jiří Slanina, Ph.D.

Anotace

ORIG CZ

V originále

A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors.

Česky

Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny je popsána

Návaznosti

GA303/00/D062, projekt VaV

Název: Biologická dostupnost a mechanismus antioxidačního účinku fenolických kyselin a lignanů

Investor: Grantová agentura ČR, Biologická dostupnost a mechanismus antioxidačního účinku fenolických kyselin a lignanů

Citovat

SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA, W. Edward ROBINSON a Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. Tetrahedron Letters. Oxford: Pergamon - Elsevier Science, 2001, roč. 42, č. 19, s. 3383-6767. ISSN 0040-4039.

@article{365191,
   author = {Slanina, Jiří and Táborská, Eva and Bochořáková, Hana and Slaninová, Iva and Humpa, Otakar and Robinson, W. Edward and Schram, Karl H.},
   article_location = {Oxford},
   article_number = {19},
   keywords = {Antivirals; biologically active compounds; isomerisation; phenolics; tannins},
   language = {eng},
   issn = {0040-4039},
   journal = {Tetrahedron Letters},
   title = {New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid},
   volume = {42},
   year = {2001}
}

TY  - JOUR
ID  - 365191
AU  - Slanina, Jiří - Táborská, Eva - Bochořáková, Hana - Slaninová, Iva - Humpa, Otakar - Robinson, W. Edward - Schram, Karl H.
PY  - 2001
TI  - New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid
JF  - Tetrahedron Letters
VL  - 42
IS  - 19
SP  - 3383
EP  - 3383
PB  - Pergamon - Elsevier Science
SN  - 00404039
KW  - Antivirals
KW  - biologically active compounds
KW  - isomerisation
KW  - phenolics
KW  - tannins
N2  - A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors.
ER  -

SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA, W. Edward ROBINSON a Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. \textit{Tetrahedron Letters}. Oxford: Pergamon - Elsevier Science, 2001, roč.~42, č.~19, s.~3383-6767. ISSN~0040-4039.

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