J
2001
Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
DVOŘÁKOVÁ, Dana, Pavel KREJČÍ, Jiří MAYER, Jiří FAJKUS, Aleš HAMPL et. al.
Basic information
Original name
Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
Authors
DVOŘÁKOVÁ, Dana (203 Czech Republic), Pavel KREJČÍ (203 Czech Republic),
Jiří MAYER (203 Czech Republic),
Jiří FAJKUS (203 Czech Republic),
Aleš HAMPL (203 Czech Republic) and
Petr DVOŘÁK (203 Czech Republic, guarantor)
Edition
British Journal of Haematology, Oxford, Blackwell Science Ltd, 2001, 0007-1048
Other information
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.815
RIV identification code
RIV/00216224:14330/01:00004756
Organization unit
Faculty of Informatics
Keywords in English
fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis
Tags
International impact, Reviewed
V originále
Patients suffering from CML express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. FGFR3 expression became upregulated again in patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia.
Links
| GA301/99/0045, research and development project | | Name: Dynamika telomer u vybraných typů solidních maligních onemocnění | | Investor: Czech Science Foundation, Telomere dynamics in selected types of solid malignant diseases |
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| IBS5004010, research and development project | | Name: Vývoj nových diagnostických technik pro onkologii | | Investor: Academy of Sciences of the Czech Republic, Development of new diagnostic teniques for oncology |
|
| MSM 143100008, plan (intention) | | Name: Genomy a jejich funkce | | Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions |
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